Implantation of autologous bone marrow cells into radiation-injured urinary bladders Regenerates functional urinary bladders
| Project/Area Number |
22791471
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Urology
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| Research Institution | Shinshu University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 再生医療 / 膀胱 / 骨髄由来細胞 / 放射線照射療法 / 排尿障害 / 放射線照射障害 / 膀胱機能障害 / 平滑筋層 / 神経線維 / ラット |
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| Research Abstract |
Implantation of bone marrow-derived cells into radiation-injured rat urinary bladders reconstructed smooth muscle layers and nerve fibers. Some of the implanted cells differentiated into smooth muscle or nerve cells. The cell-implanted urinary bladders recovered regular voiding intervals and low residual volume. Therefore, the implantation of bone marrow-derived cells would be treatments for radiotherapy-induced bladder dysfunction.
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Report
(3 results)
Research Products
(44 results)
