Implantation of autologous bone marrow cells into radiation-injured urinary bladders Regenerates functional urinary bladders

• Project/Area Number: 22791471
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Urology
• Research Institution: Shinshu University
• Principal Investigator: IMAMURA Tetsuya 信州大学, 医学部, 助教 (00467143)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 再生医療 / 膀胱 / 骨髄由来細胞 / 放射線照射療法 / 排尿障害 / 放射線照射障害 / 膀胱機能障害 / 平滑筋層 / 神経線維 / ラット

Research Abstract

Implantation of bone marrow-derived cells into radiation-injured rat urinary bladders reconstructed smooth muscle layers and nerve fibers. Some of the implanted cells differentiated into smooth muscle or nerve cells. The cell-implanted urinary bladders recovered regular voiding intervals and low residual volume. Therefore, the implantation of bone marrow-derived cells would be treatments for radiotherapy-induced bladder dysfunction.

Research Products

• [Journal Article] Bone Marrow-Derived Cells Implanted into Radiation-Injured Urinary Bladders Reconstruct Functional Bladder Tissues in Rats (2012)
  • Author(s): Imamura T, Ishizuka O, Lei Z, Hida S, Sudha GS, Kato H, Nishizawa O
  • Journal Title: Tissue Eng Part A Volume: (in press) Issue: 15-16 Pages: 1698-1709
  • DOI: 10.1089/ten.tea.2012.0061
  • NAID: 120007110571
  • Peer Reviewed
• [Journal Article] A Galenical of Traditional Chinese Herbal Mixture (THC-002) Reduces Expression of Tachykinin Peptides within Urethras of Spontaneously Hypertensive Rats (2012)
  • Author(s): 石川雅邦、今村哲也, 他5名
  • Journal Title: Neurourology and Urodynamics Volume: 31 Issue: 1 Pages: 201-206
  • DOI: 10.1002/nau.21179
  • Peer Reviewed
• [Journal Article] Analysis of the pressure-flow study in weak detrusor patients with benign prostatic hypertrophy (2011)
  • Author(s): 田辺智明, 石塚修, 市野みどり, 小川輝之, 今村哲也
  • Journal Title: LUTS Volume: 3 Pages: 109-112
  • Peer Reviewed
• [Journal Article] Implantation of autologous bone marrow-derived cells reconstructs functional urethral sphincters in rabbits (2011)
  • Author(s): 今村哲也, 石塚修, 杵渕芳明
  • Journal Title: Tissue Engineering Volume: 7 Issue: 7-8 Pages: 1069-1081
  • DOI: 10.1089/ten.tea.2010.0478
  • NAID: 120007110472
  • Peer Reviewed
• [Journal Article] Relation between expression ofα1-adrenoceptor mRNAs in bladder mucosa and urodynamic findings in men with lower urinary tract symptom (2011)
  • Author(s): 栗崎功己, 石塚修, 今村哲也
  • Journal Title: Scandinavian Journal of Urology and Nephrology Volume: 45 Issue: 1 Pages: 15-19
  • DOI: 10.3109/00365599.2010.515611
  • Peer Reviewed
• [Journal Article] Rat Bladders Augmented witha Novel Bovine Pericardium-Derived Biomaterial Reconstruct Functional Tissue Structures (2010)
  • Author(s): 三村裕司, 今村哲也, 杵渕芳明
  • Journal Title: LUTS Volume: 2 Pages: 76-82
  • Peer Reviewed
• [Journal Article] Differentiation of Smooth Muscle Cells from Human Amniotic Mesenchymal Cells Implanted in The Freeze-injured Mouse Urinary Bladder (2010)
  • Author(s): 皆川倫範, 今村哲也, 相澤直樹
  • Journal Title: European Urology Volume: 58 Pages: 299-306
  • NAID: 120007107384
  • URL: http://dx.doi.org/10.1016/j.eururo.2009.12.031
  • Peer Reviewed
• [Journal Article] CXCR3 Binding Chemokine and TNFSF14 Over Expressionin Bladder Urothelium of Patients With Ulcerative Interstitial Cystitis (2010)
  • Author(s): 小川輝之
  • Journal Title: The Journal of Urology Volume: 83 Pages: 1206-1212
  • URL: http://dx.doi.org/10.1016/j.juro.2009.11.007
  • Peer Reviewed
• [Journal Article] Autologous Bone-Marrow-Derived Mesenchymal Stem Cell Transplantation into Injured Rat Urethral Sphincter (2010)
  • Author(s): 杵渕芳明, 相澤直樹, 今村哲也
  • Journal Title: International Journal of Urology Volume: 17 Issue: 4 Pages: 359-368
  • DOI: 10.1111/j.1442-2042.2010.02471.x
  • NAID: 10027258036
  • Peer Reviewed
• [Journal Article] Stimulation of Skin Menthol Receptors Stimulates Detrusor Activity in Conscious Rats (2010)
  • Author(s): 陳忠, 石塚修, 今村哲也
  • Journal Title: Neurourology and Urodynamics Volume: 29 Issue: 3 Pages: 506-511
  • DOI: 10.1002/nau.20774
  • Peer Reviewed
• [Journal Article] Bone Marrow-Derived Cells Implanted into Freeze-injured Urinary Bladders Reconstructs Functional Smooth Muscle Layers. (2010)
  • Author(s): 今村哲也, 他4名
  • Journal Title: LUTS Volume: 2 Pages: 1-10
  • Peer Reviewed
• [Journal Article] Stimulation of Skin Menthol Receptors Stimulates Detrusor Activity in Conscious Rats. (2010)
  • Author(s): 陳忠、今村哲也
  • Journal Title: Neurourology and Urodynamics Volume: 29 Pages: 506-511
  • Peer Reviewed
• [Journal Article] Autologous Bone-Marrow-Derived Mesenchymal Stem Cell Transplantation into Injured Rat Urethral Sphincter. (2010)
  • Author(s): 杵渕芳明、今村哲也
  • Journal Title: International Journal of Urology Volume: 17 Pages: 359-368
  • NAID: 10027258036
  • Peer Reviewed
• [Journal Article] CXCR3 Binding Chemokine and TNFSF14 Over Expression in Bladder Urothelium of Patients With Ulcerative Interstitial Cystitis. (2010)
  • Author(s): 小川輝之、今村哲也
  • Journal Title: The Journal of Urology Volume: 183 Pages: 1206-1212
  • Peer Reviewed
• [Journal Article] Differentiation of Smooth Muscle Cells from Human Amniotic Mesenchymal Cells Implanted in The Freeze-injured Mouse Urinary Bladder. (2010)
  • Author(s): 皆川倫範、今村哲也
  • Journal Title: European Urology Volume: 58 Pages: 299-306
  • NAID: 120007107384
  • Peer Reviewed
• [Journal Article] Rat Bladders Augmented with a Novel Bovine Pericardium-Derived Biomaterial Reconstruct Functional Tissue Structures. (2010)
  • Author(s): 三村裕次、今村哲也
  • Journal Title: LUTS Volume: 2 Pages: 76-82
  • Peer Reviewed
• [Journal Article] Expression of α1-Adrenergic Receptor Subtypes and Angiotensin II Type 1 Receptors in the Prostate of Spontaneously Hypertensive Rats. (2010)
  • Author(s): 中山剛、今村哲也
  • Journal Title: The Shinshu Medical Journal Volume: 58 Pages: 103-114
  • NAID: 130004551784
  • Peer Reviewed
• [Journal Article] 骨髄由来細胞移植による膀胱再生 (2010)
  • Author(s): 今村哲也, 他3名
  • Journal Title: 排尿障害プラクティス Volume: 18 Pages: 36-44
  • NAID: 130004810169
• [Journal Article] 最新のトピックス 骨髄由来細胞移植による膀胱再生 (2010)
  • Author(s): 今村哲也
  • Journal Title: 信州医学雑誌 Volume: 58 Pages: 263-265
• [Journal Article] Bone marrow-derived cells implanted into radiation-injured urinary bladders reconstructs functional bladder tissues in rats
  • Author(s): 今村哲也, 他6名
  • Journal Title: Tissue Engineering Part A Volume: (in press)(Epub ahead of print)
  • NAID: 120007110571
  • Peer Reviewed
• [Journal Article] The relationship between toe temperature and lower urinary tract symptoms
  • Author(s): 井上博夫、今村哲也, 他6名
  • Journal Title: LUTS Volume: (in press)(Epub ahead of print)
  • Peer Reviewed
• [Presentation] ラット放射線照射傷害膀胱モデルを用いた骨髄由来細胞移植による膀胱再生の試み (2011)
  • Author(s): 今村哲也
  • Organizer: 第4回排尿傷害モデル動物研究会
  • Place of Presentation: 静岡
  • Year and Date: 2011-11-25
• [Presentation] ラット放射線照射傷害膀胱モデルを用いた骨髄由来細胞移植による膀胱再生の試み (2011)
  • Author(s): 今村哲也
  • Organizer: 第8回泌尿器再建再生研究会
  • Place of Presentation: 静岡市
  • Year and Date: 2011-11-25
• [Presentation] Implantation of bone marrow-derived cells recovers radiation injured urinary bladders in rats (2011)
  • Author(s): 今村哲也
  • Organizer: The 6th Pan-Pacific Continence Society Meeting
  • Place of Presentation: Taipei
  • Year and Date: 2011-09-24
• [Presentation] 冷えストレスによる下部尿路傷害の治療と予防を目指し((シンポジウム) (2011)
  • Author(s): 今村哲也
  • Organizer: 第18回日本排尿機能学会総会
  • Place of Presentation: 福井
  • Year and Date: 2011-09-17
• [Presentation] 冷えストレスによる下部尿路障害の治療と予防を目指して (2011)
  • Author(s): 今村哲也
  • Organizer: 第18回日本排尿機能学会シンポジウム
  • Place of Presentation: 福井市
  • Year and Date: 2011-09-17
• [Presentation] Imp lantation of autologous bone marrow-derived cells recove rsurethral sphincter in rabbits (2011)
  • Author(s): 今村哲也
  • Organizer: The 41th Annual Meeting of the International Continence Society
  • Place of Presentation: Glasgow
  • Year and Date: 2011-08-30
• [Presentation] 放射線照射によるラット膀胱機能障害モデルを用いた骨髄由来細胞移植による膀胱再生の試み(研究会賞受賞演題) (2011)
  • Author(s): 今村哲也
  • Organizer: 第8回泌尿器科再建再生研究会
  • Place of Presentation: 京都
  • Year and Date: 2011-06-11
• [Presentation] 放射線照射によるラット膀胱機能障害モデルを用いた骨髄由来細胞移植による膀胱再生の試み【泌尿器再建再生研究会賞受賞演題】 (2011)
  • Author(s): 今村哲也
  • Organizer: 第8回泌尿器再建再生研究会
  • Place of Presentation: 京都市
  • Year and Date: 2011-06-11
• [Presentation] 塩分負荷による自然発症高血圧ラット膀胱でのα1交感神経受容体発現変化についての検討 (2011)
  • Author(s): 今村哲也
  • Organizer: 第99回日本泌尿器科学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-04-24
• [Presentation] 骨髄由来細胞移植による膀胱再生の試み (2011)
  • Author(s): 今村哲也
  • Organizer: 第99回日本泌尿器科学会総会シンポジウム
  • Place of Presentation: 名古屋市
  • Year and Date: 2011-04-24
• [Presentation] 骨髄由来細胞移植による膀胱再生の試み(シンポジウム) (2011)
  • Author(s): 今村哲也
  • Organizer: 第99回日本泌尿器科学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-04-23
• [Presentation] ウサギ自己骨髄由来細胞移植による機能的な尿道組織再生への試み (2011)
  • Author(s): 今村哲也
  • Organizer: 第10回日本再生医療学会総会
  • Place of Presentation: 東京
  • Year and Date: 2011-03-01
• [Presentation] Implantation of autologous bone marrow-derived cells recovers urethral sphincter in rabbits (2011)
  • Author(s): 今村哲也
  • Organizer: The 41th Annual Meeting of the International Continence Society
  • Place of Presentation: Glasgow
• [Presentation] 凍結傷害を受けた膀胱組織での骨髄細胞移植による膀胱平滑筋層の再構築における環境の解明 (2010)
  • Author(s): 今村哲也
  • Organizer: 第3回排尿障害モデル動物研究会
  • Place of Presentation: 静岡市
  • Year and Date: 2010-11-26
• [Presentation] ウサギ自己骨髄細胞移植による膀胱頚部組織再生の試み(研究会賞受賞演題) (2010)
  • Author(s): 今村哲也
  • Organizer: 第7回泌尿器科再建再生研究会
  • Place of Presentation: 札幌
  • Year and Date: 2010-09-19
• [Presentation] Autologous bone marrow-derived cells recovers urethral sphincter structures composed skeletal and smooth muscle in rabbit bladder necks (2010)
  • Author(s): 今村哲也
  • Organizer: The 5th Pan-Pacific Continence Society Meeeting
  • Place of Presentation: 韓国
  • Year and Date: 2010-09-03
• [Presentation] ウサギ膀胱頚部傷害モデルを用いた自己骨髄細胞移植による組織再生の試み (2010)
  • Author(s): 今村哲也
  • Organizer: 第7回泌尿器科再建再生研究会
  • Place of Presentation: 札幌
  • Year and Date: 2010-06-19
• [Presentation] ウサギ腹圧性尿失禁モデルを用いた自己骨髄由来細胞移植による尿失禁改善への検討 (2010)
  • Author(s): 今村哲也
  • Organizer: 第98回日本泌尿器科学会総会
  • Place of Presentation: 盛岡
  • Year and Date: 2010-04-27
• [Presentation] Autologous Bone Marrow-Derived Cells Recovers Urethral Sphincter Structures Composed of Skeletal and Smooth Muscle in Rabbit Bladder (2010)
  • Author(s): 今村哲也
  • Organizer: The 5^<th> Pan-Pacific Continence Society Meeting
  • Place of Presentation: 韓国、済州
• [Book] Embryonic Stem Cells : Chapter 16 (2011)
  • Author(s): 今村哲也
  • Total Pages: 9
  • Publisher: Published by InTech
• [Remarks]
  • URL: http://www.shinshu-u.ac.jp/faculty/medicine/chair/urology/luts/index.html
• [Remarks]
  • URL: http://www.shinshu-u.ac.jp/faculty/medicine/chair/urology/luts/index.html
• [Remarks]
  • URL: http://www.shinshu-u.ac.jp/faculty/medicine/chair/urology/luts/index.html