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Development of novel intravesical agents for the treatment of refractory superficial bladder cancer

Research Project

Project/Area Number 22791473
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Urology
Research InstitutionOkayama University

Principal Investigator

WATANABE Masami  岡山大学, 岡山大学病院, 准教授 (70444677)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords膀胱癌 / 遺伝子治療 / 抗癌免疫 / 分化 / 癌
Research Abstract

Bladder cancer is one of the most common urogenital malignancies. The intravesical instillation of anti-cancer agent is an attractive strategy to treat a superficial lesion or floating/disseminated cancer cells after transurethral operation. An adenovirus carrying REIC/Dkk-3, a tumor suppressor gene,(Ad-REIC) exhibits cancer-specific apoptotic effects in various types of cancer cells. In this study, we demonstrated that the intravesical instillation of Ad-REIC could be an attractive therapeutic method for the treatment of human bladder cancer.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (14 results)

All 2012 2011 2010

All Journal Article (11 results) (of which Peer Reviewed: 11 results) Book (2 results) Patent(Industrial Property Rights) (1 results) (of which Overseas: 1 results)

  • [Journal Article] Partial sensitization of human bladder cancer cells to a gene-therapeutic adenovirus carrying REIC/Dkk-3 by downregulation of BRPK/PINK1.2012

    • Author(s)
      Jin Y, Murata H, Sakaguchi M, Kataoka K, Watanabe M, Nasu Y, Kumon H
    • Journal Title

      Huh NH. Oncol Rep.

      Volume: 27(3) Pages: 695-9

    • DOI

      10.3892/or.2011.1543

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Preclinical safety and efficacy of in situ REIC/Dkk-3 gene therapy for prostate cancer2012

    • Author(s)
      Kawauchi K, Watanabe M, Kaku H, Huang P, Sasaki K, Sakaguchi M, Ochiai K, Huh NH, Nasu Y, Kumon H
    • Journal Title

      Acta Med Okayama

      Volume: 66(1) Pages: 7-16

    • NAID

      120003850603

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Partial sensitization of human bladder cancer cells to a gene-therapeutic adenovirus carrying REIC/Dkk-3 by downregulation of BRPK/PINK12012

    • Author(s)
      Jin Y, Murata H, et al
    • Journal Title

      Oncol Rep

      Volume: 27 Pages: 695-9

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tumor suppressor REIC/Dkk-3 interacts with the dynein light chain, Tctex-12011

    • Author(s)
      Ochiai K, Watanabe M, Ueki H, Huang P, Fujii Y, Nasu Y, Noguchi H, Hirata T, Sakaguchi M, Huh NH, Kashiwakura Y, Kaku H, Kumon H
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 412(2) Pages: 391-5

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Single Nucleotide Polymorphism WRN Leu1074Phe Is Associated with Prostate Cancer Susceptibility in Chinese Subjects2011

    • Author(s)
      Lei Wang, Haruki Kaku, Peng Huang, Kexin Xu, Kai Yang, Jiheng Zhang, Ming Li, Liping Xie, Xiaofeng Wang, Akiko Sakai, Masami Watanabe, Yasutomo Nasu, Kenji Shimizu, Hiromi Kumon, Yanqun Na
    • Journal Title

      Acta Med Okayama

      Volume: (In press)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Advanced two-step transcriptional amplification as a novel method for cancer-specific gene expression and imaging.2011

    • Author(s)
      Watanabe M, Ueki H, Ochiai K, Huang P, Kobayashi Y, Nasu Y, Sasaki K, Kaku H, Kashiwakura Y, Kumon H
    • Journal Title

      Oncol Rep

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Implications of transcriptional factor, OCT-4, in human bladder malignancy and tumor recurrence2011

    • Author(s)
      Huang P, Chen J, Wang L, Na Y, Kaku H, Ueki H, Sasaki K, Yamaguchi K, Zhang K, Saika T, Nasu Y, Watanabe M, Kumon H
    • Journal Title

      Med Oncol

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Tumor growth and metastasis suppression by Glipr1 gene-modified macrophages in a metastatic prostate cancer model.2011

    • Author(s)
      Tabata K, Kurosaka S, Watanabe M, Edamura K, Satoh T, Yang G, Abdelfattah E, Wang J, Goltsov A, Floryk D, Thompson TC
    • Journal Title

      Gene Ther

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Tumor suppressor REIC/Dkk-3 interacts with the dynein light chain, Tctex-12011

    • Author(s)
      Ochiai K, Watanabe M, et al
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 412 Pages: 391-5

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression pattern of REIC/Dkk-3 in various cell types and the implications of the soluble form in prostatic acinar development.2010

    • Author(s)
      Zhang K, et al.
    • Journal Title

      Int J Oncol.

      Volume: 37 Pages: 1495-1501

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Potent antitumor effects of combined therapy with a telomerase-specific, replication-competent adenovirus (OBP-301) and IL-2 in a mouse model of renal cell carcinoma.2010

    • Author(s)
      Huang P, et al.
    • Journal Title

      Cancer Gene Ther.

      Volume: 17 Pages: 484-491

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Book] REIC/Dkk-3 gene therapy2011

    • Author(s)
      Watanabe M, Kaku H, Huan g P, Kumon H, Nasu Y
    • Publisher
      Nihon Rinsho
    • Related Report
      2011 Final Research Report
  • [Book] Suicide gene and immuno gene therapy for prostate cancer2011

    • Author(s)
      Nasu Y, Sasaki K, Kumon H, Kaku H, Watanabe M
    • Publisher
      Nihon Rinsho
    • Related Report
      2011 Final Research Report
  • [Patent(Industrial Property Rights)] 遺伝子発現を上昇させるシステム及び該システムを保持したベクター2011

    • Inventor(s)
      公文裕巳, 他
    • Industrial Property Rights Holder
      岡山大学, 他
    • Filing Date
      2011-01-14
    • Related Report
      2010 Annual Research Report
    • Overseas

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Published: 2010-08-23   Modified: 2016-04-21  

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