Regeneration of cavernous nerve after transplantation of CD 133+ cells derived from human peripheral blood and placement of biodegradable gel sponge sheet.
| Project/Area Number |
22791475
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Urology
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| Research Institution | Hiroshima University |
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Principal Investigator |
SHOGO Inoue 広島大学, 病院, 病院助教 (90457177)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
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| Keywords | 前立腺癌 / 神経再生 / 陰茎海綿体神経 / アルギン酸ゲルシート / CD133陽性細胞 / 前立腺 / 陰茎海綿体神 |
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| Research Abstract |
The aim of this study was to develop an easier nerve-regenerating technique without sutures by applying an alginate gel sponge sheet and investigate acceleration of axonal regeneration induced by the transplantation of the human peripheral blood-derived CD133+ cells into a rat cavernous nerve defect model. The intracavernous pressure(ICP) response elicited by elemental stimulation of the major pelvic ganglion(MPG) was evaluated. The MPG was exposed, and a needle was into the corpus cavernosum and the femoral artery, respectively, to monitor the ICP and mean arterial pressure(MAP). There is no significant difference in ICP/ MAP ratio between the alginate sheet group and the cavernous nerve dissection group(p=0. 74). In contrast, ICP/ MAP ratio is significantly higher in the CD133+ cells transplantation group than the cavernous nerve dissection group(p=0. 01).
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Report
(3 results)
Research Products
(3 results)
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[Presentation] ヒト骨髄由来CD133陽性細胞を用いたラット陰茎海綿体神経の再生2012
Author(s)
宮本克利, 柴田昌紀, 池田健一郎, 稗田圭介, 正路晃一, 増本弘史, 井上省吾, 小林加直, 林哲太郎, 梶原充, 亭島淳, 松原昭郎
Organizer
第100回日本泌尿器科学会総会
Place of Presentation
神奈川県横浜市
Year and Date
2012-04-23
Related Report
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