| Project/Area Number |
22791475
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Urology
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| Research Institution | Hiroshima University |
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Principal Investigator |
SHOGO Inoue 広島大学, 病院, 病院助教 (90457177)
|
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| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
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| Keywords | 前立腺癌 / 神経再生 / 陰茎海綿体神経 / アルギン酸ゲルシート / CD133陽性細胞 / 前立腺 / 陰茎海綿体神 |
|---|
| Research Abstract |
The aim of this study was to develop an easier nerve-regenerating technique without sutures by applying an alginate gel sponge sheet and investigate acceleration of axonal regeneration induced by the transplantation of the human peripheral blood-derived CD133+ cells into a rat cavernous nerve defect model. The intracavernous pressure(ICP) response elicited by elemental stimulation of the major pelvic ganglion(MPG) was evaluated. The MPG was exposed, and a needle was into the corpus cavernosum and the femoral artery, respectively, to monitor the ICP and mean arterial pressure(MAP). There is no significant difference in ICP/ MAP ratio between the alginate sheet group and the cavernous nerve dissection group(p=0. 74). In contrast, ICP/ MAP ratio is significantly higher in the CD133+ cells transplantation group than the cavernous nerve dissection group(p=0. 01).
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