| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Research Abstract |
1. Influence on BCG infection rate in bladder cancer cell line by cAMP activator administering: After BCG had been infected with the human bladder cancer cell line, the cAMP activator was administered. The infection of BCG was controlled to the density of cAMP activator.
2. Examination of change in cellular growth factor related to cAMP: The expression of PKA that is the cellular growth factor related to cAMP has increased by about 2-3 times compared with cAMP activator non-administering group.
3. Influence on tumor proliferation by cAMP activator administering: First, BBN was administered to the mouse. After 8 weeks, BCG and cAMP activator were administered to the bladder and ventral cavity, respectively. After 26 weeks, the bladders were removed and the bladder was weighed. The weight of the bladder was 2.68g and 2.83g in the cAMP activator non-administration group and the cAMP activator administering group respectively. A significant difference was not admitted though the tendency with a little weight of the bladder was shown in the cAMP activator non-administration group compared with the cAMP activator administering group.
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