Oxygen nano-bubble water reduces renal calcium oxalate deposits and renal tubular cell injury in a hyperoxaluric rat model

• Project/Area Number: 22791483
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Urology
• Research Institution: Nagoya City University
• Principal Investigator: HIROSE Yasuhiko 名古屋市立大学, 大学院・医学研究科, 研究員 (60381894)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 高シュウ酸尿症 / 酸素ナノバブル水 / 腎結石 / 炎症 / 細胞障害 / 腎結石形成ラットモデル / 尿路結石 / ナノバブル / 尿路結石形成モデル動物 / 酸化ストレス

Research Abstract

Kidney stone resembles arteriosclerosis in the mechanism, calcification composition and epidemiology. Water including oxygen nano-bubbles(nanometer-sized bubbles generated from oxygen microbubbles ; ONB water) has anti-inflammatory effects. Based on these anti-inflammatory effects, ONB water has been reported as a useful therapy for atherosclerosis. Therefore, we investigated the inhibitory effects of ONB water on kidney stone formation using a hyperoxaluric rat model. Our results suggest that ONB water reduces crystal retention in hyperoxaluric rats due to decreased renal tubular cell injury and resulting expression of crystal binding molecules(osteopontin : OPN and hyaluronic acid : HA).

Research Products

• [Presentation] 酸素ナノバブル水は尿路結石形成を抑制する (2011)
  • Author(s): 廣瀬泰彦
  • Organizer: 第7回ナノバブル研究会
  • Place of Presentation: 東京
  • Year and Date: 2011-12-02
• [Presentation] 酸素ナノバブル水は尿路結石形成を抑制する (2011)
  • Author(s): 廣瀬泰彦
  • Organizer: 第7回ナノバブル研究会
  • Place of Presentation: 東京医科歯科大学3号館(東京都)
  • Year and Date: 2011-12-02
• [Book] 泌尿器科レジデントマニュアル(監修郡健二郎、編集佐々木昌一、戸澤啓一、丸山哲史) (2011)
  • Author(s): 廣瀬泰彦
  • Publisher: 医学書院