Elucidation of the mechanism and involvement of mitochondrial collapes in the initial process of kidney stone formation
| Project/Area Number |
22791484
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Urology
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| Research Institution | Nagoya City University |
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Principal Investigator |
NIIMI Kazuhiro 名古屋市立大学, 大学院・医学研究科, 研究員 (70551274)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | アポトーシス / シクロスポリン / ミトコンドリア / 尿細管細胞傷害 / 酸化ストレス / ミトコンドリア傷害 / 尿路結石 / 細胞傷害 / 腎尿細管細胞傷害 / Cyclosporine A |
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| Research Abstract |
We have shown that the kidney stone formations are significantly suppressed by the administration of CsA. In addition, we have succeeded in suppressing apoptosis and generation of oxidative stress by preventing mitochondrial collapes by blocking the mPTP opening. The result of this study showed that the mPTP opening via cyclophilin D activity induced the renal tubular cell injury through the apoptosis and oxidative stress in the initial process of kidney stone formations. I thought that this study can be applied to the development of new therapeutic agents for kdneystone disease.
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Report
(4 results)
Research Products
(22 results)
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[Journal Article] Mitocondrial permeability transition pore opening induces the initial process of renal calcium crystallization2012
Author(s)
Niimi Kazuhiro, Yasui Takahiro, Hirose Masahito, Hamamoto Shuzo, Itoh Yasunori, Okada Atsushi, Kubota Yasue, Kojima Yoshiyuki, Tozawa Keiichi, Sasaki Shoichi, Hayashi Yutaro, Kohri Kenjiro
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Journal Title
Free Radical Biology & Medicine
Volume: 52
Issue: 7
Pages: 1207-1217
DOI
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Peer Reviewed
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[Presentation] Opening of mitochondrial permeability transition pores induces kidney stone formation.2011
Author(s)
Niimi Kazuhiro, Yasui Takahiro, Taguchi Kazumi, Fujii Yasuhiro, Hirose Yasuhiko, Kobayashi Takahiro, Hamamoto Shuzo, Hirose Masahito, Okada Atsushi, Itoh Yasunori, Tozawa Keiichi, Kohri Kenjiro
Organizer
1st Meeting of the EAU Section of Urolithiasis (EULIS)
Place of Presentation
London(United Kingdom)
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