Chemoprevention for prostate cancer using Lo-MYC mice

• Project/Area Number: 22791489
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Urology
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: IWATA Tsuyoshi 京都府立医科大学, 医学研究科, 助教 (00552209)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 前立腺癌 / マウス / C-MYC / 免疫組織化学 / 組織標本

Research Abstract

We verified that MYC mice develop PIN and early prostate cancer that resemble the human disease. Our new data show: (i) C-MYC appears to be sufficient to morphologically transform prostate cells into PIN; (ii) C-MYC protein is decreased and Nkx3.1 protein is increased transiently during invasion; (iii) inflammatory cell infiltrates accompany the development and progression of PIN to prostate cancer. These results validate the MYC mouse to model early human prostate cancer and reveal complex dynamics of C-MYC and Nkx3.1 protein expression and inflammation during disease progression.

Research Products

• [Journal Article] Global levels of H3K27me3 track with differentiation in vivo and are deregulated by MYC in prostate cancer (2012)
  • Author(s): L.G. Pellakuru, T. Iwata, et al
  • Journal Title: Am J pathol Volume: 181(2) Pages: 560-9
• [Journal Article] Global levels of H3K27me3 track with differentiation in vivo and are deregulated by MYC in prostate cancer. (2012)
  • Author(s): Pellakuru LG, Iwata T et al
  • Journal Title: Am J Pathol Volume: 181(2) Issue: 2 Pages: 560-569
  • DOI: 10.1016/j.ajpath.2012.04.021
  • Peer Reviewed
• [Journal Article] Myc enforces overexpression of EZH2 in early prostatic neoplasia via transcriptional and post-transcriptional mechanisms (2011)
  • Author(s): C.M. Koh, T. Iwata et al
  • Journal Title: Oncotarget Volume: 2(9) Pages: 669-83
• [Journal Article] Alterations in nuclear structure and gene expression programs in prostatic neoplasia are driven by the MYC oncogene (2011)
  • Author(s): C.M. Koh, B. Gurel, T. Iwata et al
  • Journal Title: Am J Pathol Volume: 178(4) Pages: 1824-34
• [Journal Article] MYC overexpression induces prostatic intraepithelial and loss of Nkx3.1 in mouse luminal epithelial cells (2010)
  • Author(s): T. Iwata, Deo. Marz, et al
  • Journal Title: PLoS One Volume: 5(2) Issue: 2 Pages: e9427-e9427
  • DOI: 10.1371/journal.pone.0009427
• [Presentation] Lo-MYCマウスにおける前立腺癌発生過程の形態学的変化とC-MYC の発現 (2010)
  • Author(s): 岩田健、高羽夏樹、三木恒治ら
  • Organizer: 第98回日本泌尿器科学会総会
  • Place of Presentation: 岩手
  • Year and Date: 2010-04-27