Chemoprevention for prostate cancer using Lo-MYC mice
| Project/Area Number |
22791489
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Urology
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
IWATA Tsuyoshi 京都府立医科大学, 医学研究科, 助教 (00552209)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 前立腺癌 / マウス / C-MYC / 免疫組織化学 / 組織標本 |
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| Research Abstract |
We verified that MYC mice develop PIN and early prostate cancer that resemble the human disease. Our new data show: (i) C-MYC appears to be sufficient to morphologically transform prostate cells into PIN; (ii) C-MYC protein is decreased and Nkx3.1 protein is increased transiently during invasion; (iii) inflammatory cell infiltrates accompany the development and progression of PIN to prostate cancer. These results validate the MYC mouse to model early human prostate cancer and reveal complex dynamics of C-MYC and Nkx3.1 protein expression and inflammation during disease progression.
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Report
(4 results)
Research Products
(6 results)
