Biological significance of expression of aryl hydrocarbon receptor in bladder cancer

• Project/Area Number: 22791494
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Urology
• Research Institution: Keio University
• Principal Investigator: ISHIDA Masaru 慶應義塾大学, 医学部, 助教 (80383876)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 腫瘍学 / 膀胱癌 / 芳香族炭化水素受容体 / 浸潤 / 発癌

Research Abstract

In clinicopathological study, the expression of aryl hydrocarbon receptor(AhR) significantly associated with lymphovascular invasion which is prognostic factor of urothelial cancer. The regulation of the expression of AhR correlated with the expression of matrix metalloproteinase(MMP) in in vitro study. Furthermore, the invasion activity of bladder cancer cell was affected by the expression status of AhR.

Research Products

• [Journal Article] Carcinoma ex pleomorphic adenoma of the submandibular gland with renal metastases composed exclusively of metastasizing pleomorphic adenoma : a case report (2012)
  • Author(s): 松島将史、石田勝, ら
  • Journal Title: International Cancer Conference Journal Volume: 1 Pages: 116-120
  • Peer Reviewed
• [Journal Article] Expression of Snail and Slug in renal cell circinoma : E-cadherin repressor Snail is associated with cancer invasion and prognosis (2011)
  • Author(s): 三上修治、石田勝, ら
  • Journal Title: Laboratory Investigation Volume: 91 Pages: 1443-1458
  • Peer Reviewed
• [Journal Article] Transumbilical laparo-endoscopic single site surgery for adrenal cortical adenoma inducing primary aldosteronism : initial experience (2011)
  • Author(s): 宮嶋哲、石田勝, ら
  • Journal Title: BMC Research Notes Volume: 4 Pages: 364-364
  • Peer Reviewed
• [Journal Article] Expression of Snail in upper urinary tract urothelial carcinoma : Prognostic significance and implications for tumor invasion (2010)
  • Author(s): Kosaka T, Mikami S, Miyajima A, Shirotake S, Ishida M, Okada Y, Oya M
  • Journal Title: Clinical Cancer Research Volume: 16(23) Pages: 5814-5823
  • Peer Reviewed
• [Journal Article] Expression of Snail in upper urinary tract urothelial carcinoma : Prognostic significance and implications for tumor invasion. (2010)
  • Author(s): Kosaka T, Mikami S, Miyajima A, Shirotake S, Ishida M, Okada Y, Oya M
  • Journal Title: Clinical Cancer Research Volume: 16 Pages: 5814-5823
  • Peer Reviewed
• [Journal Article] Technical difficulties of transumbilical laparoendoscopic single-site a drenalectomy : comparison with conventional laparoscopic adrenalectomy. (2010)
  • Author(s): Ishida M, Miyajima A, Takeda T, Hasegawa M, Kikuchi E, Oya M
  • Journal Title: World Journal of Urology Volume: (in press)
  • Peer Reviewed
• [Presentation] Activation of the aryl hydrocarbon receptor pathway enhances cancer cell invasion by up-regulating the MMP expression in urothelial cancer (2011)
  • Author(s): Ishida M, Mikami S, Kikuchi E, Kosaka T, Miyajima A, Mukai M, Okada Y, Oya M
  • Organizer: The 106th annual meeting of American Urological Association
  • Place of Presentation: アメリカワシントンDC
  • Year and Date: 2011-05-16
• [Presentation] Metastin, the final peptide of KISS-1 gene, prevents lung metastases of murine bladder cancer (2011)
  • Author(s): Takeda T, Kikuchi E, Suzuki E, Ito Y, Ishida M, Matsumoto K, Miyajima A, Mikami S, Oya M
  • Organizer: The 106th annual meeting of American Urological Association
  • Place of Presentation: アメリカワシントンDC
  • Year and Date: 2011-05-16
• [Presentation] Activation of the aryl hydrocarbon receptor pathway enhances cancer cell invasion by up-regulating the MMP expression in urothelial cancer (2011)
  • Author(s): 石田勝
  • Organizer: The 106^<th> annual meeting of American Urological Association
  • Place of Presentation: 米国ワシントン
  • Year and Date: 2011-05-16
• [Presentation] Metastin, the final peptide of KISS-1 gene, prevents lung metastases of murine bladder cancer (2011)
  • Author(s): 武田利和、石田勝
  • Organizer: The 106^<th> annual meeting of American Urological Association
  • Place of Presentation: 米国ワシントン
  • Year and Date: 2011-05-16
• [Presentation] Activation of aryl hydrocarbon receptor promotes epithelial-mesenchymal transition of renal cell carcinoma by inducing Slug and matrix metalloproteinases. (2011)
  • Author(s): Masaru Ishida
  • Organizer: 26th Annual European Association of Urology Congress
  • Place of Presentation: Vienna, Austria
  • Year and Date: 2011-03-20
• [Presentation] Activation of the AhR pathway enhances cancer cell invasion by up-regulating the MMP expression in urothelial cancer (2010)
  • Author(s): Ishida M, Mikami S, Kikuchi E, Kosaka T, Miyajima A, Nakagawa K, Mukai M, Okada Y, Oya M
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪
  • Year and Date: 2010-09-24
• [Presentation] Activation of the AhR pathway enhances cancer cell invasion by up-regulating the MMP expression in urothelial cancer. (2010)
  • Author(s): Masaru Ishida
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪
  • Year and Date: 2010-09-24
• [Presentation] 腎細胞癌の発癌・浸潤における芳香族炭化水素受容体の発現の意義 (2010)
  • Author(s): Masaru Ishida
  • Organizer: 第98回日本泌尿器科学会総会
  • Place of Presentation: 岩手
  • Year and Date: 2010-04-30
• [Presentation] Activation of the aryl hydrocarbon receptor is associated with cigarette smoke, poor prognosis and cancer cell invasion in renal cell carcinoma. (2010)
  • Author(s): Masaru Ishida
  • Organizer: 25th Annual European Association of Urology Congress
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2010-04-18
• [Remarks]
  • URL: http://www.keio-urology.jp/achievement/index.html
• [Remarks]
  • URL: http://www.keio-urology.jp/achievement/index.html
• [Remarks]
  • URL: http://www.keio-urology.jp/achievement/index.html