The molecular mechanisms of angiogenic aggressiveness after chemotherapeutic agents in bladder cancer.

• Project/Area Number: 22791495
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Urology
• Research Institution: Keio University
• Principal Investigator: TANAKA Nobuyuki 慶應義塾大学, 医学部, 助教 (60445244)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 血管新生 / シスプラチン / 活性酸素 / 膀胱癌 / レニンアンギオテンシン / AT1R / Aniotensin II / CDDP / ATIR / Reactive oxen secies

Research Abstract

We elucidated the molecular mechanisms of upregulating angiotensin II type 1 receptor and angiotensin II-dependent angiogenesis after CDDP treatments in bladder cancer. We further elucidated the upregulation of angiogenic aggressiveness thorough angiotensin II pathway in acquired platinum-resistant bladder cancer.

Research Products

• [Journal Article] PROGNONSTIC IMPACT OF RENIN-ANGIOTENSIN SYSTEM BLOCKADE IN LOCALIZED UPPER TRACT UROTHELIAL CARCINOMA (2012)
  • Author(s): Tanaka N, Miyajima A, Kikuchi E, Matsumoto K, Hagiwara M, Ide H, Kosaka T, Masuda T, Nakamura S, Oya M
  • Journal Title: Br J Cancer Volume: 106 Pages: 290-6
  • Peer Reviewed
• [Journal Article] Prognostic Value of Plasma Fibrinogen Levels in Patients with Localized Upper Tract Urothelial Carcinoma (2012)
  • Author(s): Tanaka N, Kikuchi E, Matsumoto K, Hayakawa N, Ide H, Miyajima A, Nakamura S, Oya M
  • Journal Title: Br J Urol Int Volume: (in press)
  • Peer Reviewed
• [Journal Article] Prognostic impact of rennin-angiotensin system blockade in localized up per-tract urothelial carcinoma (2012)
  • Author(s): Nobuyuki Tanaka
  • Journal Title: British Journal of Cancer Volume: 106 Pages: 290-6
  • Peer Reviewed
• [Journal Article] Acquired Platinum Resistance Enhances Tumor Angiogenesis through Angiotensin II Type 1 Receptor in Bladder Cancer (2011)
  • Author(s): Tanaka N, Miyajima A, Kosaka T, Miyazaki Y, Kikuchi E, Oya M
  • Journal Title: Br J Cancer Volume: 105 Pages: 1331-7
  • Peer Reviewed
• [Journal Article] Acquired Platinum Resistance Enhances Tumor Angiogenesis through Angiotensin II Type 1 Receptor in Bladder Cancer (2011)
  • Author(s): Nobuyuki Tanaka
  • Journal Title: British Journal of Cancer Volume: 105 Pages: 1331-7
  • Peer Reviewed
• [Journal Article] Cis-dichlorodiammineplatinum upregulates angiotensin II type 1 receptors through reactive oxygen species generation and enhances VEGF production in bladder cancer (2010)
  • Author(s): Tanaka N, Miyajima A, Kosaka T, Shirotake S, Hasegawa M, Kikuchi E, Oya M
  • Journal Title: Mol Cancer Ther Volume: 9 Pages: 2982-92
  • Peer Reviewed
• [Journal Article] Cis-dichlorodiammineplatinum Up-regulates Angiotensin II Type 1 Receptor Through Reactive Oxygen Species Generation and Enhance VEGF Production in Bladder Cancer (2010)
  • Author(s): Nobuyuki Tanaka
  • Journal Title: Molecular Cancer Therapeautics Volume: 9 Pages: 2982-92
  • Peer Reviewed
• [Presentation] Acquired Platinum Resistance Induces Angiogenic Aggressiveness Through Upregulation of Angiotensin II Type 1 Receptors in Bladder Cancer (2012)
  • Author(s): Tanaka N, Miyajima A, Kosaka T, et al
  • Organizer: 2012年米国泌尿器科学会
  • Place of Presentation: 米国
  • Year and Date: 2012-05-21
• [Presentation] Reactive Oxygen Species Generation Increased by Cis-dichlorodiammineplatinum Enhances VEGF Production through Upregulating Angiotensin II Type 1 Receptor in Bladder Cancer (2011)
  • Author(s): Tanaka N, Miyajima A, Kosaka T, et al
  • Organizer: 2011年米国泌尿器科学会
  • Place of Presentation: 米国
  • Year and Date: 2011-05-16
• [Presentation] Reactive Oxygen Species Generation Increased by Cis-dichlorodiammineplatinum Enhances VEGF Production through Upregulating Angiotensin II Type 1 Receptor in Bladder Cancer (2011)
  • Author(s): Nobuyuki Tanaka
  • Organizer: 2011 American Urological Association Annual Meeting
  • Place of Presentation: Washington, USA
  • Year and Date: 2011-05-16
• [Presentation] Cis-dichlorodiammineplatinum up-regulates angiotensin II type 1 receptor, and enhances vascular endothelial growth factor production in bladder cancer. (2010)
  • Author(s): Nobuyuki Tanaka
  • Organizer: 2010 American Urological Association Annual Meeting
  • Place of Presentation: Sanfrancisco, CA, USA
  • Year and Date: 2010-05-31
• [Presentation] Cis-dichlorodiammineplatinum up-regulates angiotensin II type 1 receptor, and enhances vascular endothelial growth factor production in bladder cancer (2010)
  • Author(s): Tanaka N, Miyajima A, Kosaka T
  • Organizer: 2010年米国泌尿器科学会
  • Place of Presentation: 米国
  • Year and Date: 2010-05-30
• [Remarks]
  • URL: http://www.keio-urology.jp
• [Remarks] 慶應義塾大学医学部泌尿器科学教室ホームページ
  • URL: http://www.keio-urology.jp