Mechanism of acquisition of hormone independency of prostate cancer xenograft model established from Japanese patient.

Research Project

Project/Area Number	22791500
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Urology
Research Institution	Jikei University School of Medicine
Principal Investigator	KIMURA Takahiro 東京慈恵会医科大学, 医学部, 講師 (00307430)
Project Period (FY)	2010 – 2011
Project Status	Completed (Fiscal Year 2011)
Budget Amount *help	¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000) Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000) Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords	前立腺癌 / 動物モデル / ホルモン抵抗性
Research Abstract	The aim of the study is to elucidate the molecular characteristics of the novel prostate cancer xenograft model from Japanese patient, JDCaP and to establish and analyze the hormone independent subline. Molecular character between JDCaP and cancerous tissue of the patient was revealed similar. The change of molecular character of hormone independent subline was indicated by the analysis.