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Study of the mechanism for controlling of sperm function via membrane structure with proteins secreted by seminal vesicle

Research Project

Project/Area Number 22791502
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Urology
Research InstitutionToin University of Yokohama

Principal Investigator

YOSHIDA Kaoru  桐蔭横浜大学, 先端医用工学センター, 講師 (70398973)

Co-Investigator(Renkei-kenkyūsha) IWAMOTO Teruaki  国際医療福祉大学, 大学病院, 教授 (60046117)
YOSHIDA Manabu  東京大学, 大学院・理学系研究科, 准教授 (60301785)
Project Period (FY) 2010-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords精子 / 受精能 / 膜ラフト / 糖脂質 / 膜タンパク質 / コレステロール / アンドロロジー / ミトコンドリア
Research Abstract

Seminal vesicle secreted protein, semenogelins(SEMGs) are one of inhibitory factor for hyperactivation of sperm motility. Our previous study has revealed that SEMGs were also inhibitory factors for acrosome reaction and protein tyrosin phosphorylation. Collectively, SEMGs may be inhibitory factors for sperm capacitation. However, it is still unclear that the direct interaction between lipid lafts and SEMGs. Our study suggests that SEMGs can bind to cholesterol and effect on sperm membrane fluidity and on function for capacitaion.

Report

(5 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (17 results)

All 2014 2013 2012 2011 2010 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Open Access: 1 results) Presentation (10 results) Book (1 results) Remarks (2 results)

  • [Journal Article] Seminal vesicle protein SVS2 is required for sperm survival in the uterus2014

    • Author(s)
      N Kawano, N Araki, K Ybshida, THibino, N Ohnami, M Makino, S Kanai, H Hasuwa, M Yoshida, K Miyado, A Umezawa
    • Journal Title

      Proceedings of the National Academy of Sciences

      Volume: 111(11) Issue: 11 Pages: 4145-4150

    • DOI

      10.1073/pnas.1320715111

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Keys to Sperm Maturation2011

    • Author(s)
      Kawano N, Yoshida K, Miyado K, and Yoshida M. Lipid Rafts
    • Journal Title

      Fertilization, and Early Embryogenesis Journal of Lipids

      Volume: (Article ID 264706)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Lipid Rafts : Keys to Sperm Maturation, Fertilization, and Early Embry ogenesis2011

    • Author(s)
      Natsuko Kawano, Kaoru Yoshida, Kenji Miyado, Manabu Yoshida
    • Journal Title

      Journal of Lipids

      Volume: 2011

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of seminal plasma motility inhibitors/semenogelins with sperm in asthenozoospermia-infertile men2010

    • Author(s)
      Terai K, Yoshida K, Yoshiike M, Fujime M, Iwamoto T.
    • Journal Title

      Urologia Internationalis

      Volume: 85 Pages: 209-215

    • Related Report
      2013 Final Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 精漿タンパク質SEMGの精子の受精能評価マーカーとしての検討2013

    • Author(s)
      吉田薫, 山崎一恭, 吉池美紀, 岩本晃明
    • Organizer
      第58回日本生殖医学会学術総会
    • Place of Presentation
      神戸国際会議場
    • Related Report
      2013 Final Research Report
  • [Presentation] 精漿タンパク質SEMGの精子の受精能評価マーカーとしての検討2013

    • Author(s)
      吉田薫 、山崎一恭、吉池美紀、岩本晃明。精漿タンパク質SEMGの精子の受精能評価マーカーとしての検討 第58回 日本生殖医学会学術総会 2013年
    • Organizer
      第58回 日本生殖医学会学術総会
    • Place of Presentation
      神戸国際会議場
    • Related Report
      2013 Annual Research Report
  • [Presentation] マウス受精能獲得抑制因子SVS2の精子膜コレステロール維持作用2012

    • Author(s)
      荒木直也, 河野菜摘子,吉田薫,宮戸健二,吉田学
    • Organizer
      日本動物学会第83回大会
    • Place of Presentation
      大阪大学
    • Related Report
      2013 Final Research Report 2012 Annual Research Report
  • [Presentation] SVS2 inhibits sperm capacitation by regulating the efflux of cholesterol from sperm plasma membrane2012

    • Author(s)
      Araki N, Yoshida K, Kawano N, Miyado K, and Yoshida M
    • Organizer
      The International Symposium on the Mechanisms of Sexual Reproduction in Animals and Plants
    • Place of Presentation
      Nagoya, Japan
    • Related Report
      2013 Final Research Report
  • [Presentation] SVS2 inhibits sperm capacitation by regulating the efflux of cholesterol from sperm plasma membrane.2012

    • Author(s)
      Araki, N., Yoshida, K., Kawano, N., Miyado, K., and Yoshida, M.
    • Organizer
      The International Symposium on the Mechanisms of Sexual Reproduction in Animals and Plants
    • Place of Presentation
      Nagoya , Japan
    • Related Report
      2012 Annual Research Report
  • [Presentation] 精嚢分泌タンパク SVS2 のマウス体内受精における役割について2011

    • Author(s)
      河野菜摘子, 荒木直也, 吉田薫, 吉田学, 宮戸健二
    • Organizer
      日本動物学会第82回大会
    • Place of Presentation
      旭川
    • Related Report
      2013 Final Research Report
  • [Presentation] マウス精子受精能獲得における精嚢分泌タンパク質SVSsの機能解析2011

    • Author(s)
      荒木直也, 吉田薫, 河野菜摘子, 宮戸健二, 吉田学
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Related Report
      2013 Final Research Report 2011 Annual Research Report
  • [Presentation] 精嚢分泌タンパクSVS2のマウス体内受精における役割について2011

    • Author(s)
      河野菜摘子、荒木直也、吉田薫、吉田学、宮戸健二
    • Organizer
      日本動物学会第82回大会
    • Place of Presentation
      旭川
    • Related Report
      2011 Annual Research Report
  • [Presentation] Evaluation of sperm quality based on SPMIs binding on ICSI outcome2010

    • Author(s)
      Terai K, Yoshida K, Yoshiike M, Iwamoto T, Matsuura R, Yoshida A
    • Organizer
      11th International Symposium on SPERMATOLOGY Okinawa 2010
    • Place of Presentation
      Okinawa Convention Center, Japan
    • Year and Date
      2010-06-02
    • Related Report
      2013 Final Research Report
  • [Presentation] Evaluation of sperm quality based on SPMIs binding on ICSI outcome2010

    • Author(s)
      Terai K, Yoshida K, Yoshiike M, Iwamoto T, Matsuura R, Yoshida A
    • Organizer
      11th International Symposium on SPERMATOLOGY Okinawa 2010
    • Place of Presentation
      Okinawa Convention Center
    • Year and Date
      2010-06-02
    • Related Report
      2010 Annual Research Report
  • [Book] Effects of the Seminal Plasma Proteins Semenogelin (SEMG)/Seminal Vesicle Secretion 2 (SVS2) on Sperm Fertility."Human Spermatozoa : Maturation, Capacitation and Abnormalities" Ed : Lejeune T and Delvaux Pascal pp205-220.2010

    • Author(s)
      Yoshida K, Iwamoto T, Yoshida M
    • Total Pages
      545
    • Publisher
      Nova Science Publishers
    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.cc.toin.ac.jp/univ/japanese/professor/bme/labot-kaoruy.html

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.cc.toin.ac.jp/univ/japanese/professor/bme/labot-kaoruy.html

    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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