| Project/Area Number |
22791502
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Urology
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| Research Institution | Toin University of Yokohama |
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Principal Investigator |
YOSHIDA Kaoru 桐蔭横浜大学, 先端医用工学センター, 講師 (70398973)
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| Co-Investigator(Renkei-kenkyūsha) |
IWAMOTO Teruaki 国際医療福祉大学, 大学病院, 教授 (60046117)
YOSHIDA Manabu 東京大学, 大学院・理学系研究科, 准教授 (60301785)
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| Project Period (FY) |
2010-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 精子 / 受精能 / 膜ラフト / 糖脂質 / 膜タンパク質 / コレステロール / アンドロロジー / ミトコンドリア |
|---|
| Research Abstract |
Seminal vesicle secreted protein, semenogelins(SEMGs) are one of inhibitory factor for hyperactivation of sperm motility. Our previous study has revealed that SEMGs were also inhibitory factors for acrosome reaction and protein tyrosin phosphorylation. Collectively, SEMGs may be inhibitory factors for sperm capacitation. However, it is still unclear that the direct interaction between lipid lafts and SEMGs. Our study suggests that SEMGs can bind to cholesterol and effect on sperm membrane fluidity and on function for capacitaion.
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