| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Research Abstract |
Uterine papillary serous carcinoma (UPSC) is a highly aggressive form of endometrial cancer and characterized by a high recurrence rate and a poor prognosis. To date, the standard treatment for UPSC has remained elusive. In the present study, we focused on microRNA (miRNA) that has been recently reported to be abnormal expressed in several cancers and the correlation between miRNA and UPSC. By introducing miRNA whose expression was down-regulated to UPSC cells suppressed cell proliferation. Furthermore, the inhibitory effects may be mediated by the suppression of the oncogenes that were showed as the targets of the miRNA. Taken together, the present study revealed that a novel and important role of miRNA as a tumor suppressor in UPSC and the identification of novel tumor-suppressive miRNA-mediated molecular pathways and targets may provide new insights into UPSC.
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