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Basic research for new treatment development using microRNA in UPSC

Research Project

Project/Area Number 22791509
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Obstetrics and gynecology
Research InstitutionTohoku University

Principal Investigator

SUZUKI Fumihiko  東北大学, 医学(系)研究科(研究院), 助教 (20400343)

Project Period (FY) 2010-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywords癌 / エピジェネティクス / miRNA / 子宮体癌 / 漿液性腺癌
Research Abstract

Uterine papillary serous carcinoma (UPSC) is a highly aggressive form of endometrial cancer and characterized by a high recurrence rate and a poor prognosis. To date, the standard treatment for UPSC has remained elusive. In the present study, we focused on microRNA (miRNA) that has been recently reported to be abnormal expressed in several cancers and the correlation between miRNA and UPSC. By introducing miRNA whose expression was down-regulated to UPSC cells suppressed cell proliferation. Furthermore, the inhibitory effects may be mediated by the suppression of the oncogenes that were showed as the targets of the miRNA. Taken together, the present study revealed that a novel and important role of miRNA as a tumor suppressor in UPSC and the identification of novel tumor-suppressive miRNA-mediated molecular pathways and targets may provide new insights into UPSC.

Report

(5 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (16 results)

All 2014 2013 2012 2011 2010 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (14 results)

  • [Journal Article] Decreased Expression of 14-3-3σ is a Potential Prognostic Factor in Human Uterine Papillary Serous Carcinoma.2013

    • Author(s)
      Fumihiko Suzuki, Satoru Nagase, Kichiya Suzuki, Etsuko Oba1, Eri Hiroki1, Yukika Matsuda, Jun-ichi Akahira, Hidekazu Nishigori1, Takashi Sugiyama1, Takeo Otsuki1, Kousuke Yoshinaga , Tadao Takano, Hitoshi Niikura, Kiyoshi Ito, Hironobu Sasano, and Nobuo Yaegashi
    • Journal Title

      Tohoku J Exp Med

      Volume: 231(3) Pages: 193-199

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] MicroRNA-34b functions as a potential tumor suppressor in endometrial serous adenocarcinoma2012

    • Author(s)
      Hiroki E, Akahira J, et al
    • Journal Title

      Int J Cancer

      Volume: (印刷中) Issue: 4 Pages: 395-404

    • DOI

      10.1002/ijc.27345

    • Related Report
      2013 Final Research Report 2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] 子宮体部漿液性腺癌に対するmiR-101を用いた分子標的治療の可能性2014

    • Author(s)
      鈴木史彦, 永瀬智, 佐藤いずみ, 宇都宮裕貴, 新倉仁, 渡部洋, 笹野公伸, 八重樫伸生
    • Organizer
      第13回日本婦人科がん分子標的研究会
    • Place of Presentation
      鳥取
    • Year and Date
      2014-03-15
    • Related Report
      2013 Final Research Report
  • [Presentation] 子宮体部漿液性腺癌においてmiR-34bは細胞増殖,遊走・浸潤およびアポトーシスに関与する2013

    • Author(s)
      鈴木 史彦, 永瀬 智, 赤平 純一, 廣木 恵理, 伊藤潔, 宇都宮 裕貴, 笹野 公伸, 八重樫伸生
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2013-10-05
    • Related Report
      2013 Final Research Report
  • [Presentation] 子宮体部漿液性腺癌おけるmicroRNA-34bの癌抑制的な機能の検討2013

    • Author(s)
      鈴木 史彦, 永瀬 智, 廣木 恵理, 宇都宮 裕貴, 伊藤 潔, 新倉 仁, 赤平 純一, 笹野 公伸, 八重樫 伸生
    • Organizer
      第65回日本産科婦人科学会学術講演会
    • Place of Presentation
      札幌
    • Year and Date
      2013-05-10
    • Related Report
      2013 Final Research Report
  • [Presentation] 子宮体部漿液性腺癌においてmiR-34b はエピジェネティックに制御され, 癌の浸潤・転移に関与する2012

    • Author(s)
      鈴木史彦, 永瀬智, 赤平純一, 廣木恵理, 伊藤潔, 宇都宮裕貴, 笹野公伸, 八重樫伸生
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌
    • Year and Date
      2012-09-21
    • Related Report
      2013 Final Research Report
  • [Presentation] 子宮体部漿液性腺癌においてmicoRNA-34bは浸潤性および足場非依存性増殖能を制御する2012

    • Author(s)
      鈴木史彦, 永瀬智, 赤平純一, 廣木恵理, 伊藤潔, 宇都宮祐貴, 菅原準一, 笹野公伸, 八重樫伸生
    • Organizer
      第64回日本産婦人科学会学術講演会
    • Place of Presentation
      神戸
    • Year and Date
      2012-04-13
    • Related Report
      2013 Final Research Report
  • [Presentation] 子宮体部漿液性腺癌においてmicroRNA-34bは浸潤能および足場非依存性増殖能を制御2012

    • Author(s)
      鈴木史彦、永瀬智、赤平純一、廣木恵理、伊藤潔、宇都宮裕貴、菅原準一、笹野公伸、八重樫伸生
    • Organizer
      第64回日本産科婦人科学会学術講演会
    • Place of Presentation
      神戸ポートピアホテル・神戸国際展示場
    • Related Report
      2012 Annual Research Report
  • [Presentation] 子宮体部漿液性腺癌においてmiR-34bはエピジェネティックに制御され、癌の浸潤・転移に関与する2012

    • Author(s)
      鈴木 史彦、 永瀬 智、 赤平 純一、 廣木 恵理、 伊藤 潔、 宇都宮 裕貴、 笹野 公伸、 八重樫 伸生
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      ホテルロイトン札幌
    • Related Report
      2012 Annual Research Report
  • [Presentation] 子宮体部漿液性腺癌(UPSC)におけるmicroRNA-34bの発現制御および機能の解明2011

    • Author(s)
      鈴木史彦, 赤平純一, 廣木恵理, 永瀬智, 伊藤潔, 宇都宮祐貴, 笹野公伸, 八重樫伸生
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-03
    • Related Report
      2013 Final Research Report 2011 Annual Research Report
  • [Presentation] 子宮体部漿液性腺癌においてmicroRNA-34bは癌抑制的な役割をもつ可能性がある2010

    • Author(s)
      廣木恵理, 赤平純一, 鈴木史彦, 永瀬智, 伊藤潔, 笹野公伸, 八重樫伸生
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪
    • Year and Date
      2010-09-24
    • Related Report
      2013 Final Research Report 2010 Annual Research Report
  • [Presentation] 子宮体部漿液性腺癌におけるマイクロ RNA の役割2010

    • Author(s)
      鈴木史彦, 赤平純一, 廣木恵理, 永瀬智, 伊藤潔, 笹野公伸, 八重樫伸生
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪
    • Year and Date
      2010-09-22
    • Related Report
      2013 Final Research Report
  • [Presentation] 子宮体部漿液性腺癌に対するmiR-101を用いた分子標的治療の可能性

    • Author(s)
      鈴木史彦、永瀬智、佐藤いずみ、宇都宮裕貴、新倉仁、渡部洋、笹野公伸、八重樫伸生
    • Organizer
      第13回日本婦人科がん分子標的研究会
    • Place of Presentation
      鳥取
    • Related Report
      2013 Annual Research Report
  • [Presentation] 子宮体部漿液性腺癌においてmiR-34bは細胞増殖、遊走・浸潤およびアポトーシスに関与する

    • Author(s)
      鈴木 史彦, 永瀬 智, 赤平 純一, 廣木 恵理, 伊藤 潔, 宇都宮 裕貴, 笹野 公伸, 八重樫伸生
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] 子宮内膜癌におけるSteroid sulfatase阻害剤の有用性に関する検討

    • Author(s)
      西本 光男、宇都宮 裕貴、志賀尚美、辻 圭太、海法道子、鈴木史彦、徳永英樹、伊藤 潔、八重樫 伸生
    • Organizer
      第65回日本産科婦人科学会学術講演会
    • Place of Presentation
      札幌
    • Related Report
      2013 Annual Research Report
  • [Presentation] 子宮体部漿液性腺癌おけるmicroRNA-34bの癌抑制的な機能の検討

    • Author(s)
      鈴木 史彦、永瀬 智、廣木 恵理、宇都宮 裕貴、伊藤 潔、新倉 仁、赤平 純一、笹野 公伸、八重樫 伸生
    • Organizer
      第65回日本産科婦人科学会学術講演会
    • Place of Presentation
      札幌
    • Related Report
      2013 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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