A possible role of luteinizing hormone receptor(LHR) in the temporal and spatial regulation of angiogenesis in the ovary

• Project/Area Number: 22791516
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Obstetrics and gynecology
• Research Institution: The University of Tokyo
• Principal Investigator: HARADA Miyuki 東京大学, 医学部附属病院, 助教 (70451812)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 卵巣 / 血管新生 / 黄体刺激ホルモン受容体(LHR) / 血管内皮増殖因子(VEGF) / 多嚢胞性卵巣症候群(PCOS) / 卵巣過剰刺激症候群(OHSS) / 多嚢胞卵巣症候群 / 卵巣過剰刺激症候群

Research Abstract

It had been well known that LH had an important role in ovarian angiogenesis. In this study, we demonstrated that not only LH but also ligand-specifically regulated LH receptor(LHR) might exert regulatory effects on temporal and spatial regulation of angiogenesis in the ovary. To modulate the LHR expression might be a new strategy for ovarian pathology stemmed from abnormal angiogenesis, such as PCOS and OHSS.

Research Products

• [Journal Article] Growth differentiation factor 3 is induced by bone morphogenetic protein 6(BMP-6) and BMP-7 and increase luteinizing hormone receptor messenger RNA expression in human granulose cells (2012)
  • Author(s): Shi J, Yoshino O, Osuga Y, Akiyama I, Harada M, Koga K, Yano T, Taketani Y
  • Journal Title: Fertil Steril Volume: 97(4) Pages: 979-83
  • Peer Reviewed
• [Journal Article] Growth differentiation factor 3 is induced by bone morphogenetic protein 6 (BMP-6) and BMP-7 and increases luteinizing hormone receptor messenger RNA expression in human granulosa cells (2012)
  • Author(s): Shi J
  • Journal Title: Feril. Steril. Volume: 97 Pages: 979-83
  • Peer Reviewed
• [Journal Article] Successful pregnancy following low-dose hCG administration in addition to hMG in a patient with hypothalamic amenorrhea due to weight loss (2011)
  • Author(s): Tsutsumi R, Fujimoto A, Osuga Y, Harada M, Takemura Y, Koizumi M, Yano T, Taketani Y
  • Journal Title: Gynecol Endocrinol Volume: (Epub ahead of print)
  • Peer Reviewed
• [Journal Article] Activin-A is induced by interleikin-1βand tumor necrosis factor-αand enhances the mRNA expression of interleukin-6 and protease-activated receptor-2 and proliferation of stromal cells from endometorioma (2011)
  • Author(s): Yoshino O, Izumi G, Shi J, Osuga Y, Hirota Y, Harada M, Nishii O, Koga K, Taketani Y
  • Journal Title: Fertil Steril Volume: 96(1) Pages: 118-21
  • Peer Reviewed
• [Journal Article] Dienogest, a new conservative strategy for extragenital endometriosis : a pilot study (2011)
  • Author(s): Harada M, Osuga Y, Izumi G, Takamura M, Takemura Y, Hirata T, Yoshino O, Koga K, Yano T, Taketani Y
  • Journal Title: Gynecol Endocrinol Volume: 27(9) Pages: 717-20
  • Peer Reviewed
• [Journal Article] Dienogest, a new conservative strategy for extragenital endometriosis : a pilot study (2011)
  • Author(s): Harada M
  • Journal Title: Gynecol Endocrinol Volume: 27 Pages: 717-720
  • Peer Reviewed
• [Journal Article] Activin-A is induced by interleukin-1βand tumor necrosis factor-α and enhances the mRNA expression of interleukin-6 and protease-activated receptor-2 and proliferation of stromal cells of endometrioma (2011)
  • Author(s): Yoshino O
  • Journal Title: Fertil Steril Volume: 96 Pages: 118-21
  • Peer Reviewed
• [Journal Article] Expression of vascular endothelial growth factor A during ligand-induced down-regulation of luteinizing hormone receptor in the ovary (2010)
  • Author(s): Harada M, Peegel H, Menon KM
  • Journal Title: Mol Cell Endocrinol Volume: 328(1-2) Pages: 28-33
  • Peer Reviewed
• [Journal Article] Case of chronic ectopic pregnancy diagnosed in which the complete shape of the fetus was visible by ultrasonography (2010)
  • Author(s): Harada M, Hiroi H, Fujiwara T, Fujimoto A, Kikuchi A, Osuga Y, Momoeda M, Kugu K, Yano T, Taketani Y
  • Journal Title: J Obstet Gynecol Res Volume: 36(2) Pages: 462-5
  • NAID: 10031121642
  • Peer Reviewed
• [Journal Article] Inhibitory effect of valproic acid on ovarian biosynthesis in rat theca interstitial cells (2010)
  • Author(s): Fisseha S, Towns R, Harada M, Peegel H, Menon KM
  • Journal Title: Endocrine Volume: 37(1) Pages: 187-93
  • Peer Reviewed
• [Journal Article] Inhibitory Effect of Valproic Acid on Ovarian Androgen Biosynthesis in Rat Theca Interstitial Cells (2010)
  • Author(s): S Fisseha
  • Journal Title: Endocrine Volume: 37 Pages: 187-193
  • Peer Reviewed
• [Journal Article] Case of chronic ectopic pregnancy diagnosed in which the complete shape of the fetus was visible by ultrasonography (2010)
  • Author(s): M Harada
  • Journal Title: J Obstet Gynaecol Res Volume: 36 Pages: 462-465
  • NAID: 10031121642
  • Peer Reviewed
• [Journal Article] Expression of Vascular Endothelial Growth Factor A During Ligand-Induced Down-Regulation of Luteinizing Hormone Receptor in the Ovary (2010)
  • Author(s): M Harada
  • Journal Title: Mol Cell Endocrionol Volume: 328 Pages: 28-33
  • Peer Reviewed
• [Journal Article] Molecular regulation of gonadotropin receptor expression : Relationship to sterol metabolism (2010)
  • Author(s): KMJ Menon
  • Journal Title: Mol Cell Endocrionol Volume: 329 Pages: 26-32
  • Peer Reviewed
• [Presentation] POF (premature ovarian failure)患者における経口エストロゲン制剤(ジュリナ)を用いた排卵誘発の試み (2011)
  • Author(s): 原田美由紀
  • Organizer: 第26回日本女性医学学会
  • Place of Presentation: 神戸
  • Year and Date: 2011-11-12
• [Presentation] 早期発症型卵巣過剰刺激症候群に対するcabergoline(カバサール)の使用経験 (2011)
  • Author(s): 原田美由紀、櫻橋彩子、藤本晃久、大須賀穣、矢野哲、武谷雄二
  • Organizer: 第56回日本生殖医学会
  • Place of Presentation: 横浜
• [Presentation] POF(premature ovarian failure)患者における経口エストロゲン製剤(ジュリナ)を用いた排卵誘発の試み (2011)
  • Author(s): 原田美由紀、平池修、吉野修、大石元、大須賀穣、矢野哲、武谷雄二
  • Organizer: 第26回日本女性医学会
  • Place of Presentation: 神戸
• [Presentation] Laparoscopic cystectomy of ovarian endometrioma may impair the response of affected ovary to controlled ovarian hyperstimulation in IVF patients (2011)
  • Author(s): Harada M, Osuga Y, Fujimoto A, Oi N, Yoshino O, Koga K, Yano T, Taketani Y
  • Organizer: 11^<th> World Congress on Endometriosis
  • Place of Presentation: モンペリエ(フランス)
• [Presentation] Changes in the Expression of Vascular Endothelial Growth Factor A (VEGF-A) mRNA during Ligand-Induced Down-Regulation of Luteinizing Hormone Receptor (LHR) in the Ovary (2010)
  • Author(s): M Harada
  • Organizer: 62^<nd> Annual Congress of the Japan Society of Obstetrics and Gynecology
  • Place of Presentation: 東京
  • Year and Date: 2010-04-23
• [Presentation] 腹腔鏡下子宮内膜症性卵巣嚢胞摘出術の、卵巣予備能へ与える影響についての検討 (2010)
  • Author(s): 原田美由紀、大須賀穣、藤本晃久、大井なぎさ、矢野哲、武谷雄二
  • Organizer: 第55回日本生殖医学会
  • Place of Presentation: 徳島
• [Presentation] Changes in the Expression of Vascular Endothelial Growth Factor A(VEGF-A) mRNA during Ligand-Induced Down-Regulation of Luteinizing Hormone Receptor(LHR) in the Ovary (2010)
  • Author(s): Harada M
  • Organizer: 62^<nd> Annual Congress of the Japan Society of Obstetrics and Gynecology
  • Place of Presentation: 東京