A possible role of luteinizing hormone receptor(LHR) in the temporal and spatial regulation of angiogenesis in the ovary
| Project/Area Number |
22791516
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
HARADA Miyuki 東京大学, 医学部附属病院, 助教 (70451812)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 卵巣 / 血管新生 / 黄体刺激ホルモン受容体(LHR) / 血管内皮増殖因子(VEGF) / 多嚢胞性卵巣症候群(PCOS) / 卵巣過剰刺激症候群(OHSS) / 多嚢胞卵巣症候群 / 卵巣過剰刺激症候群 |
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| Research Abstract |
It had been well known that LH had an important role in ovarian angiogenesis. In this study, we demonstrated that not only LH but also ligand-specifically regulated LH receptor(LHR) might exert regulatory effects on temporal and spatial regulation of angiogenesis in the ovary. To modulate the LHR expression might be a new strategy for ovarian pathology stemmed from abnormal angiogenesis, such as PCOS and OHSS.
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Report
(3 results)
Research Products
(21 results)
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[Journal Article] Dienogest, a new conservative strategy for extragenital endometriosis : a pilot study2011
Author(s)
Harada M, Osuga Y, Izumi G, Takamura M, Takemura Y, Hirata T, Yoshino O, Koga K, Yano T, Taketani Y
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Journal Title
Gynecol Endocrinol
Volume: 27(9)
Pages: 717-20
Related Report
Peer Reviewed
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