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Implication of adipocytokines in implantation and establishment of pregnancy

Research Project

Project/Area Number 22791517
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Obstetrics and gynecology
Research InstitutionTeikyo University (2011)
The University of Tokyo (2010)

Principal Investigator

TAKEMURA Yuri  帝京大学, 医学部, 助教 (00453697)

Co-Investigator(Renkei-kenkyūsha) OSUGA Yutaka  東京大学, 大学院・医学系研究科, 教授 (80260496)
Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords着床 / 子宮内膜 / アディポサイトカイン / AMP キナーゼ
Research Abstract

The imbalance of adipocytokines, adipocyte-derived cytokines, has the potential to impair implantation and establishment of pregnancy through abnormality in the control of inflammatory response in the human endometrium. The expression of adiponectin, one of adipocytokines, receptors was increased in the endometrium in the implantation period and the expressions of adiponectin receptors and AMPK phosphorylations were decreased in the endometirium of infertile women i n the implantation period compared with fertile women, suggesting that adiponectin and metformin-induced AMPK phosphorylation may play a facilitatory role in the implantation.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (20 results)

All 2013 2012 2011 2010

All Journal Article (10 results) (of which Peer Reviewed: 6 results) Presentation (10 results)

  • [Journal Article] 若手の最新研究紹介コーナー2013

    • Author(s)
      竹村由里
    • Journal Title

      産科と婦人科

      Volume: 80 Pages: 376-378

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Journal Article] Increased risk of placenta previa is associated with endometriosis and tubal factor infertility in assisted reproductive technology pregnancy2013

    • Author(s)
      Takemura;Osuga;Fujimoto;Oi;Tsutsumi;Koizumi;Harada;Yano;Taketani .
    • Journal Title

      Gynecological Endocrinology

      Volume: 29 Issue: 2 Pages: 113

    • DOI

      10.3109/09513590.2012.706669

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Recurrence of endometrioma after laparoscopic excision and its prevention by medical management2013

    • Author(s)
      Koga K, Osuga Y, Takemura Y, et al.
    • Journal Title

      Front Biosci

      Volume: 5 Pages: 676-683

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Successful pregnancy following low-dose hCG administration in addition to hMG in a patient with hypothalamic amenorrhea due to weight loss2012

    • Author(s)
      Tsutsumi R, Fujimoto A, Osuga Y, Harada M, Takemura Y, Koizumi M, Yano T, Taketani Y.
    • Journal Title

      Gynecol Endocrinol

      Volume: 28 Issue: 6 Pages: 460

    • DOI

      10.3109/09513590.2011.633650

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] オフィスギネコロジー I 思春期 不正性器出血、過多月経、月経困難症2012

    • Author(s)
      竹村由里、西井 修
    • Journal Title

      臨床婦人科産科 増刊号

      Volume: 66 Pages: 15-19

    • Related Report
      2011 Annual Research Report
  • [Journal Article] High Mobility Group Box 1 (HMGB1) Levels in the Placenta and in Serum in Preeclampsia.2011

    • Author(s)
      Wang B, Koga K, Osuga Y, Hirato T, Saito A, Yoshino O, Hirota Y, Harada M, Takemura Y, et al
    • Journal Title

      Am J Reprod Immunol.

      Volume: (Epub ahead of print)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] アディポネクチン/AdipoR と子宮内膜および子宮内膜症2010

    • Author(s)
      竹村由里、大須賀穣
    • Journal Title

      治療学

      Volume: 44 Pages: 1255-1259

    • Related Report
      2011 Final Research Report
  • [Journal Article] アディポネクチン/AdipoRと子宮内膜および子宮内膜症2010

    • Author(s)
      竹村由里、大須賀穣
    • Journal Title

      治療学

      Volume: 44巻11号 Pages: 1255-1259

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Recruitment of CCR6-expressing Th17 cells by CCL 20 secreted from IL-1 beta-, TNF-alpha-, and IL-17A-stimulated endometriotic stromal cells.2010

    • Author(s)
      Hirata T, Osuga Y, Takamura M, Kodama A, Hirota Y, Koga K, Yoshino O, Harada M, Takemura Y, et al
    • Journal Title

      Endocrinology

      Volume: 151 Pages: 5468-76

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dienogest, a new conservative strategy for extragenital endometriosis : a pilot study.2010

    • Author(s)
      Harada M, Osuga Y, Izumi G, Takamura M, Takemura Y, et al
    • Journal Title

      Gynecol Endocrinol.

      Volume: (Epub ahead of print)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 子宮腺筋症に対するジェノゲストの効果2011

    • Author(s)
      泉玄太郎、平田哲也、甲賀かをり、大須賀穣、永井美和子、浦田陽子、高村将司, 齊藤亜子、長谷川亜希子、北麻里子、竹村由里, ら
    • Organizer
      第32回日本エンドメトリオーシス学会
    • Place of Presentation
      東京
    • Year and Date
      2011-01-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] Endometriosis and risk of placenta previa in pregnancies after assisted reproductive technology2010

    • Author(s)
      Yuri Takemura, Akihisa Fujimoto, Yutaka Osuga, et al
    • Organizer
      ESHRE 2010, 26th Annual Meeting
    • Place of Presentation
      Rome, Italy
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] TGFβは子宮内膜症細胞においてPAR2の発現ならびに機能を増強する2010

    • Author(s)
      児玉亜子, 大須賀穣, 吉野修, 泉玄太郎, 高村将司, 長谷川亜希子, 竹村由里, ら
    • Organizer
      第62回日本産科婦人科学会学術講演会
    • Place of Presentation
      東京
    • Related Report
      2010 Annual Research Report
  • [Presentation] 子宮内膜ポリープに対する黄体・卵胞ホルモン混合製剤の効果についての検討2010

    • Author(s)
      平池修, 大須賀穣, 竹村由里, ら
    • Organizer
      第62回日本産科婦人科学会学術講演会
    • Place of Presentation
      東京
    • Related Report
      2010 Annual Research Report
  • [Presentation] 子宮腺筋症に対するDienogestの効果2010

    • Author(s)
      泉玄太郎, 平田哲也, 甲賀かをり, 大須賀穣, 高村将司, 小倉さやか, 児玉亜子, 北麻里子, 竹村由里, ら
    • Organizer
      第62回日本産科婦人科学会学術講演会
    • Place of Presentation
      東京
    • Related Report
      2010 Annual Research Report
  • [Presentation] 腹腔鏡下子宮内膜症性卵巣嚢胞摘出術後の再発率低下に低用量ピル(OC)は有益である2010

    • Author(s)
      高村将司, 甲賀かをり, 泉玄太郎, 児玉亜子, 田島敏樹, 長谷川亜希子, 竹村由里, ら
    • Organizer
      第62回日本産科婦人科学会学術講演会
    • Place of Presentation
      東京
    • Related Report
      2010 Annual Research Report
  • [Presentation] 子宮体癌・子宮内膜異型増殖症に対する子宮温存治療後のART成績に関する検討2010

    • Author(s)
      市瀬茉里, 藤本晃久, 大井なぎさ, 渡辺裕子, 渡邉善, 竹村由里, ら
    • Organizer
      第55回日本生殖医学会学術講演会
    • Place of Presentation
      徳島
    • Related Report
      2010 Annual Research Report
  • [Presentation] 子宮内膜症組織,子宮内膜,末梢血液におけるCD4陽性T細胞subsetの解析2010

    • Author(s)
      高村将司, 大須賀穣, 泉玄太郎, 児玉亜子, 竹村由里, ら
    • Organizer
      第55回日本生殖医学会学術講演会
    • Place of Presentation
      徳島
    • Related Report
      2010 Annual Research Report
  • [Presentation] 当科におけるConventional IVFおよびICSIにおける異数前核胚の出現頻度と妊娠例2010

    • Author(s)
      大井なぎさ, 藤本晃久, 小泉美奈子, 原田美由紀, 竹村由里, ら
    • Organizer
      第55回日本生殖医学会学術講演会
    • Place of Presentation
      徳島
    • Related Report
      2010 Annual Research Report
  • [Presentation] 子宮卵管造影用油性造影剤の腹腔内の免疫学的環境に与える影響-樹状細胞やT細胞の分画に着目して-2010

    • Author(s)
      泉玄太郎, 高村将司, 甲賀かをり, 大須賀穣, 児玉亜子, 竹村由里, ら
    • Organizer
      第55回日本生殖医学会学術講演会
    • Place of Presentation
      徳島
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2016-04-21  

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