Basic research of the simultaneous therapy targeting NFkB and EGFR to treat KRAS-mutated endometrial cancer

• Project/Area Number: 22791520
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Obstetrics and gynecology
• Research Institution: Kanazawa University
• Principal Investigator: MIZUMOTO Yasunari 金沢大学, 附属病院, 助教 (00420331)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2010: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 子宮内膜癌 / KRAS変異 / NFkB / 抗EGFR抗体

Research Abstract

We have demonstrated in the experiment that anti-EGFR therapy against KRAS-mutated endometrial cancer does not show anti-tumor activity. To target NFkB, the dominant effecter pathway activated downstream of KRAS mutation, seems to be effective strategy to treat KRAS-mutated endometrial cancer

Research Products

• [Journal Article] Activation of NF-kappaB is a novel target of KRAS-induced endometrialcar cinogenesis (2011)
  • Author(s): Mizumoto Y, Kyo S, Kiyono T, Takakura M, Nakamura M, Maida Y, Nori N, Bono Y, Sakurai H, Inoue M
  • Journal Title: Clin Cancer Res Volume: 17(6) Issue: 6 Pages: 1341-50
  • DOI: 10.1158/1078-0432.ccr-10-2291
  • Peer Reviewed
• [Journal Article] Forkhead transcription factor FOXO1 is a direct target of progestin to inhibit endometrial epithelial cell growth (2011)
  • Author(s): Kyo S, Sakaguchi J, Kiyono T, Shimizu Y, Maida Y, Mizumoto Y, Mori N, Nakamura M, Takakura M, Miyake K, Sakamoto M, Inoue M
  • Journal Title: Clin Cancer Res Volume: 17(3) Issue: 3 Pages: 525-37
  • DOI: 10.1158/1078-0432.ccr-10-1287
  • Peer Reviewed
• [Journal Article] Prognostic impact of CD133 expression as a tumor-initiating cell marker in endometrial cancer (2010)
  • Author(s): Nakamura M, Kyo S, Zhang B, Zhang X, Mizumoto Y, Takakura M, Maida Y, Mori N, Hashimoto M, Ohno S, Inoue M
  • Journal Title: Hum Pathol Volume: 41(11) Issue: 11 Pages: 1516-29
  • DOI: 10.1016/j.humpath.2010.05.006
  • Peer Reviewed
• [Journal Article] Expression of HER-2 affects patient survival and paclitaxel sensitivity in endometrial cancer (2010)
  • Author(s): Mori N, Kyo S, Nakamura M, Hashimoto M, Maida Y, Mizumoto Y, Takakura M, Ohono S, Kiyono T, noue M
  • Journal Title: Br J Cancer Volume: 103(6) Issue: 6 Pages: 889-98
  • DOI: 10.1038/sj.bjc.6605805
  • Peer Reviewed