| Project/Area Number |
22791521
|
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
|---|
| Research Field |
Obstetrics and gynecology
|
|---|
| Research Institution | Kanazawa University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Keywords | 子宮内膜癌 / 幹細胞 / CD133 |
|---|
| Research Abstract |
In endometrial cancer cells, CD133-positive cells had properties of self-renewal, tumorigenesis and differentiation, suggesting that CD133 was a potential cancer stem cell(CSC) marker. Immunohistological analysis showed that CD133 expression was significantly associated with overall survival and the independent predictive factor of survival. Furthermore, endometrial CSCs demonstrated high expression of genes associated with multi-drug resistance, invasion and metastasis, indicating that endometrial CSCs are aggressive malignant cancer cells.
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