Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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Research Abstract |
In this study, the mismatch repair(MMR) abnormalities in the carcinogenetic process of endometriosis were analyzed. The immunohistochemical expressions of mismatch repair proteins were step-wisely decreased in normal entopic endometrium, endometriosis, and ovarian carcinoma. Inversely, the step-wisely increasing frequencies of microsatellite instability in normal entopic endometrium, endometriosis, and ovarian carcinoma were observed. In addition, the down-regulations of MMR proteins were observed in cultured normal endometrial glandular cells under the condition with inflammatory cytokines(TNF-α, IL-6). These findings suggest that mismatch repair abnormalities, which are induced by inflammation, might be involved in the malignant transformation of ovarian endometriosis.
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