Comprehensive analysis of local immune state of ovarian cancers may provide a tool for the application of immune therapies to treat ovarian cancer patients.

• Project/Area Number: 22791527
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Obstetrics and gynecology
• Research Institution: Kyoto University
• Principal Investigator: HAMANISHI Junzo 京都大学, 医学研究科, 助教 (80378736)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 婦人科腫瘍学 / 卵巣癌 / 免疫寛容 / 免疫環境 / 抗がん剤 / 免疫療法

Research Abstract

Comprehensive analysis of local immune state of ovarian cancers by using hierarchical clustering of tumor-infiltrating immune cells and immunosuppressive factors was used to identify a subgroup of ovarian cancer patients with a better prognosis. This study also suggested that immunosuppressive factors might influence the pattern of tumor-infiltrating immune cells. The analyses shown here may lead to a precise understanding of the local immune status and provide a tool for the application of immune therapies to treat ovarian cancer patients.

Research Products

• [Journal Article] The activated transforming growth factor-beta signaling pathway in peritoneal metastases is a potential therapeutic target in ovarian cancer. (2012)
  • Author(s): Yamamura S, Matsumura N, Mandai M, Huang Z, Oura T, Baba T, Hamanishi J, Yamaguchi K, Kang HS, Okamoto T, Abiko K, Mori S, Murphy SK, Konishi I.
  • Journal Title: Int J Cancer. Volume: 130(1) Pages: 20-8
  • DOI: 10.1002/ijc.25961
  • Peer Reviewed
• [Journal Article] The comprehensive assessment of local immune status of ovarian cancer by the clustering of multiple immune factors. (2011)
  • Author(s): Hamanishi J, Mandai M, Abiko K, Matsumura N, Baba T, Yoshioka Y, Kosaka K, Konishi I
  • Journal Title: Clin Immunol Volume: 141(3) Pages: 338-47
  • URL: http://dx.doi.org/10.1016/j.clim.2011.08.013
• [Journal Article] Ovarian clear cell carcinoma as astress-responsive cancer : influence of the microenvironment on the carcinogenesis and cancer phenotype. (2011)
  • Author(s): Mandai M, Matsumura N, Baba T, Yamaguchi K, Hamanishi J, Konishi I.
  • Journal Title: Cancer Lett. Volume: 310(2) Pages: 129-33
  • URL: http://dx.doi.org/10.1016/j.canlet.2011.06.039
• [Journal Article] GPR54 is a target for suppression of metastasis in endometrial cancer. (2011)
  • Author(s): Kang HS, Baba T, Mandai M, Matsumura N, Hamanishi J, Kharma B, Kondoh E, Yoshioka Y, Oishi S, Fujii N, Murphy SK, Konishi I.
  • Journal Title: Mol Cancer Ther. Volume: 10(4) Pages: 580-90
  • DOI: 10.1158/1535-7163.mct-10-0763
  • Peer Reviewed
• [Journal Article] Distinguishing primary from secondarymucinous ovarian tumors : an algorithm using the novel marker DPEP1 (2011)
  • Author(s): Okamoto T, Matsumura N, Mandai M, Oura T, Yamanishi Y, Horiuchi A, Hamanishi J, Baba T, Koshiyama M, Shiozawa T, Konishi I.
  • Journal Title: Mod Pathol. Volume: 24(2) Pages: 267-76
• [Journal Article] The comprehensive assessment of local immune status of ovarian cancer by the clustering of multiple immune factors. (2011)
  • Author(s): Hamanishi J, Mandai M, Abiko K, Matsumura N, Baba T, Yoshioka Y, Kosaka K, Konishi I.
  • Journal Title: Clin Immunol. Volume: 141(3) Pages: 338-347
  • DOI: 10.1016/j.clim.2011.08.013
  • NAID: 120003610113
  • Peer Reviewed
• [Journal Article] Suppression of metastatic murineovarian cancer cells by transducedembryonic progenitor cells. (2010)
  • Author(s): Mandai M, Hamanishi J, Abiko K, Matsumura N, Baba T, Yoshioka Y, Konishi I.
  • Journal Title: Horm Cancer Volume: 1(6) Pages: 291-6
  • DOI: 10.1007/s12672-010-0046-2
  • Peer Reviewed
• [Journal Article] Oct4 expression in immature teratoma of the ovary : relevance to histologic grade and degree of differentiation. (2010)
  • Author(s): Abiko K, Mandai M, Hamanishi J, Matsumura N, Baba T, Horiuchi A, Mikami Y, Yoshioka S, Wakasa T, Shiozawa T, Konishi I.
  • Journal Title: Am J Surg Pathol Volume: 34(12) Pages: 1842-8
  • DOI: 10.1097/pas.0b013e3181fcd707
  • Peer Reviewed
• [Journal Article] Sorafenib efficacy in ovarian clear cell carcinoma revealed by transcriptomeprofiling. (2010)
  • Author(s): Matsumura N, Mandai M, Okamoto T, Yamaguchi K, Yamamura S, Oura T, Baba T, Hamanishi J, Kang HS, Matsui S, Mori S, Murphy SK, Konishi I.
  • Journal Title: Cancer Sci. Volume: 101(12) Pages: 2658-63
• [Presentation] 高得点演題「進行卵巣癌に対する化学療法は腫瘍局所の免疫状態を変化させる」 (2011)
  • Author(s): 濱西潤三, 万代昌紀, 松村謙臣, 馬場長, 安彦郁, 山村省吾, 姜賢淑, 吉岡弓子, 奈倉道和, 小阪謙三, 小西郁生
  • Organizer: 第63回日本産科婦人科学会学術集会
  • Place of Presentation: 大阪・大阪国際会議場
  • Year and Date: 2011-08-29
• [Presentation] 進行卵巣癌に対する化学療法は腫瘍局所の免疫状態を変化させる (2011)
  • Author(s): 濱西潤三
  • Organizer: 第63回日本産科婦人科学会学術集会高得点演題
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2011-08-29
• [Presentation] 「卵巣癌に対する抗がん剤治療は腫瘍局所の免疫を変化させる」"The immunologic change in ovarian cancer patients after chemotherapy" (2011)
  • Author(s): 濱西潤三, 万代昌紀, 小西郁生
  • Organizer: 第15回日本がん免疫学会
  • Place of Presentation: 大阪千里ライフサイエンスセンタービル
  • Year and Date: 2011-06-30
• [Presentation] 卵巣癌に対する抗がん剤治療は腫瘍局所の免疫を変化させる"The immunologic change in ovarian cancer patients after chemotherapy (2011)
  • Author(s): 濱西潤三
  • Organizer: 第15回日本がん免疫学会
  • Place of Presentation: 千里ライフサイエンスセンタービル
  • Year and Date: 2011-06-30
• [Presentation] <産婦人科>婦人科腫瘍の臨床 (2011)
  • Author(s): 濱西潤三
  • Organizer: 京都府院内がん登録部会講演会
  • Place of Presentation: 京都
  • Year and Date: 2011-03-05
• [Presentation] 子宮がん検診の現在・未来『若年子宮頸がんの問題点』 (2011)
  • Author(s): 濱西潤三
  • Organizer: 日本医師会生涯教育協力講座シンポジウム
  • Place of Presentation: 京都
  • Year and Date: 2011-01-29
• [Presentation] The immunologic change in advanced ovarian cancer patients after chemotherapy(抗がん剤治療により進行卵巣がんの局所免疫は変化する) (2010)
  • Author(s): Hamanishi J, Mandai M, Noriomi Matsumura, Tsukasa Baba, Yumiko Yoshioka, Shogo Yamamura, Takako Okamoto, Hyun Sook Kang, Kaoru Abiko, Michikazu Nagura, Kenzo Kosaka and Konishi I.
  • Organizer: 第69回日本癌学会学術講演会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2010-09-23
• [Presentation] The immunologic change in advanced ovarian cancer patients after chemotherapy (2010)
  • Author(s): 濱西潤三
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2010-09-22
• [Presentation] 基調講演「卵巣癌に対する免疫療法の可能性を求めて」 (2010)
  • Author(s): 濱西潤三, 万代昌紀, 松村謙臣, 馬場長, 山村省吾, 吉岡弓子, 岡本尊子, 姜淑賢, 安彦郁, 奈倉道和, Budiman, Kharma Hishamu, Abou-Tarebu, Peng Jin, 小阪謙三, 小西郁生
  • Organizer: 京都婦人科腫瘍フォーラム
  • Place of Presentation: 京都市
  • Year and Date: 2010-09-16
• [Presentation] 卵巣癌に対する免疫療法の可能性を求めて (2010)
  • Author(s): 濱西潤三
  • Organizer: 京都婦人科腫瘍フォーラム
  • Place of Presentation: ウエスチン都ホテル京都(招待講演)
  • Year and Date: 2010-09-16
• [Presentation] 「癌研究の最近のトピックス」「血管内皮前駆細胞を用いた新規がん免疫療法の基礎的検討」 (2010)
  • Author(s): 濱西潤三、万代昌紀、松村謙臣、馬場長、山村省吾、岡本尊子、姜淑賢、吉岡弓子、安彦郁、小阪謙三、Budiman Kharma、Hishamu Abou-Tarebu、小西郁生
  • Organizer: 第51回日本組織細胞化学会学術集会ワークショップ
  • Year and Date: 2010-09-04
• [Presentation] 血管内皮前駆細胞を用いた新規がん免疫療法の基礎的検討 (2010)
  • Author(s): 濱西潤三
  • Organizer: 第51回日本組織細胞化学会総会
  • Place of Presentation: 秋葉原コンベンションホル(招待講演)
  • Year and Date: 2010-09-04
• [Presentation] The immunologic change in advanced ovarian cancer patients after chemotherapy with paclitaxel or carboplatin (2010)
  • Author(s): 濱西潤三
  • Organizer: 14th International congress of Immunology(第14回国際免疫学会議)
  • Place of Presentation: 神戸国際展示場
  • Year and Date: 2010-08-22
• [Presentation] Mini-Symposium～Unsolved problems and questions in cancer research～「Immunotherapy for recurrent ovarian cancer, a new challenge of strategy (2010)
  • Author(s): Junzo Hamanishi
  • Organizer: 2010 Annual Retreat in Cancer Area Kyoto University Global COE Program
  • Place of Presentation: Pias group Sophiewood, Otsu
  • Year and Date: 2010-07-04
• [Presentation] 高得点演題「卵巣癌局所における免疫環境を推測する新たな解析法とその意義」 (2010)
  • Author(s): 濱西潤三、万代昌紀、松村謙臣、馬場長、安彦郁、岡本尊子、山村省吾、姜賢淑、吉岡弓子、Budiman Kharma、八木治彦、小阪謙三、小西郁生
  • Organizer: 第62回日本産科婦人科学会学術講演会
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2010-04-25
• [Presentation] 優秀論文賞受賞講演「ケモカインCCL19遺伝子を導入した胚性血管内皮前駆細胞を用いた局所免疫の活性化は、卵巣癌の転移を抑制する」 (2010)
  • Author(s): 濱西潤三、万代昌紀、松村謙臣、馬場長、山口建、(藤井信吾)、小西郁生
  • Organizer: 第62回日本産科婦人科学会学術講演会
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2010-04-25
• [Presentation] 卵巣癌局所における免疫環境を推測する新たな解析法とその意義 (2010)
  • Author(s): 濱西潤三
  • Organizer: 第62回日本産科婦人科学会学術講演会
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2010-04-25
• [Presentation] The immunologic change in advanced ovarian cancer patients after chemotherapy with paclitaxel or carboplatin (2010)
  • Author(s): Hamanishi J, Mandai M, Konishi I.
  • Organizer: 14th International congress ofImmunology
• [Remarks] ホームページ
  • URL: http://www.kuhp.kyoto-u.ac.jp/~obgy/