Development and analysis of a novel preeclampsia model using a placenta-specific gene manipulation method.

• Project/Area Number: 22791528
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Obstetrics and gynecology
• Research Institution: Hokkaido University
• Principal Investigator: MORIOKA Yuka 北海道大学, 遺伝子病制御研究所, 特任助教 (00360264)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 妊娠高血圧症候群 / 胎盤 / レンチウイルスベクター

Research Abstract

Previously, we established a placenta-specific gene manipulation method. Applying this technology, we expressed soluble VEGF receptor 1(sFLT1) known as an anti-angiogenic factor, specifically in the murine placenta. The mice showed hypertension and proteinuria during pregnancy. These are similar symptoms of human preeclampsia patients. We further showed that pravastatin induced the VEGF-like angiogenic factor placental growth factor(PGF) and ameliorated the symptoms.

Research Products

• [Journal Article] Pravastatin induces placental growth factor (PGF) and ameliorates preeclampsia in a mouse model (2011)
  • Author(s): Kumasawa K, Ikawa M, Kidoya H, Hasuwa H, Saito-Fujita T, Morioka Y, Takakura N, Kimura T, Okabe M
  • Journal Title: Proc Natl Acad Sci U S A Volume: 108 Issue: 4 Pages: 1451-5
  • DOI: 10.1073/pnas.1011293108
  • Peer Reviewed
• [Journal Article] Pravastatin induces placental growth factor (PGF) and ameliorates preeclampsia in a mouse model. (2011)
  • Author(s): Keiichi Kumasawa
  • Journal Title: Proc.Natl.Acad.Sci.USA. Volume: 108 Pages: 1451-1455
  • Peer Reviewed