| Project/Area Number |
22791532
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Tottori University |
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Principal Investigator |
SATO Shinya 鳥取大学, 医学部附属病院, 助教 (10423261)
|
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| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
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| Keywords | 婦人科腫瘍学 / 卵巣癌 / 粘液性腺癌 / 抗癌剤耐性 |
|---|
| Research Abstract |
(1) A negligible increase in inhibition of cell growth induced by CDDP was detected in the presence of PI3K inhibitor in all cell lines. We observed a decrease the cytotoxicity of CDDP when CDDP was combined with MEK inhibitor. Interestingly, cell growth was dramatically suppressed when CDDP was combined with PMA in all the cells that were resistant to CDDP. After treatment with CDDP and PMA, the proportion of the cells in G0/G1 phase and G2/M phase were decreased, and the proportion of cells in the S-phase fraction was dramatically increased, and then the cell cycle distribution was shifted to the subG1 phase in the CDDP resistant cells.
(2) Treatment with CDDP and PMA prolonged survival in nude mice bearing ovarian cancer cells.
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