| Project/Area Number |
22791537
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Oita University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | 生殖医学 / 子宮内膜症 / Bufarin / β-HIVS / Semaphorin / アポトーシス / 細胞周期 / Bufalin |
|---|
| Research Abstract |
We have been worked about the elucidation of the pathogenesis of endometriosis and the development of new drugs for this disease. This time, we detected that Bufarin,β-HIVS, and, BAY had the function to stop the cell cycle of endometriotic cells. The patterns of arrest of the cell cycle were G0-G1.
In addition, we focused on the new agents, semaphorin which is the anti-factor for neuron cells, and we detected that this agents also induced apoptosis for the endometriotic cells as well as Bufarin,β-HIVS, and BAY.
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