Elucidation of the mechanism how HLA-E and HLA-G form the population of decidual mononuclear cells
| Project/Area Number |
22791541
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Nara Medical University |
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Principal Investigator |
OUJI Noriko 奈良県立医科大学, 医学部, 助教 (30398432)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 生殖医学 / HLA-G / HLA-E / NK細胞 / 脱落膜 |
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| Research Abstract |
To contribute to forming the population of decidual mononuclear cells, the specific and strong expression of HLA-E and HLA-G on placental trophoblast should be important. Recently, many reports showed the presence of HLA-G not only on placental trophoblast but also on other tissue. To verify those results, the expression of HLA-G in follicle fluids was tested by ELISA and immunoprecipitation. We have got the contradicted result between these 2 methods. It was considered that the contradiction was caused from a false-positive reaction induced by a substance in follicle fluids on ELISA. The cause of this contradiction should be analyzed, and the detection method of HLA-G with higher sensitivity is going to be established.
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Report
(3 results)
Research Products
(3 results)
