• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Elucidation of the mechanism how HLA-E and HLA-G form the population of decidual mononuclear cells

Research Project

Project/Area Number 22791541
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Obstetrics and gynecology
Research InstitutionNara Medical University

Principal Investigator

OUJI Noriko  奈良県立医科大学, 医学部, 助教 (30398432)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords生殖医学 / HLA-G / HLA-E / NK細胞 / 脱落膜
Research Abstract

To contribute to forming the population of decidual mononuclear cells, the specific and strong expression of HLA-E and HLA-G on placental trophoblast should be important. Recently, many reports showed the presence of HLA-G not only on placental trophoblast but also on other tissue. To verify those results, the expression of HLA-G in follicle fluids was tested by ELISA and immunoprecipitation. We have got the contradicted result between these 2 methods. It was considered that the contradiction was caused from a false-positive reaction induced by a substance in follicle fluids on ELISA. The cause of this contradiction should be analyzed, and the detection method of HLA-G with higher sensitivity is going to be established.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (3 results)

All 2011 2010

All Presentation (3 results)

  • [Presentation] 成人T細胞白血病ウイルス感染者のT細胞表面におけるHLA-Fの発現についての検討2011

    • Author(s)
      吉岡聡
    • Organizer
      第20回日本組織適合性学会大会
    • Place of Presentation
      ツインメッセ静岡北館(静岡県)
    • Year and Date
      2011-08-29
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] HLA-E with HLA-G-derived peptide on trophoblast binds CD56^<bright> NK cells strongly and may contribute the accumulation of NK cells in decidua2010

    • Author(s)
      王寺典子
    • Organizer
      第14回国際免疫学会議
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2010-08-27
    • Related Report
      2011 Final Research Report
  • [Presentation] HLA-E with HLA-G-derived peptide on trophoblast binds CD56^<bright> NK cells strongly and may contribute the accumulation of NK cells in decidua.2010

    • Author(s)
      王寺典子
    • Organizer
      第14回国際免疫学会議
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2010-08-27
    • Related Report
      2010 Annual Research Report

URL: 

Published: 2010-08-23   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi