MicroRNA as a new target for ovarian cancer therapy
| Project/Area Number |
22791542
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Saitama Medical University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 婦人科腫瘍学 / マイクロRNA / 癌 / 遺伝子 / 発現制御 |
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| Research Abstract |
To determine if the microRNA would be the therapeutic targets for ovarian cancer, we investigated the biological function of the microRNA in ovarian cancer. We observed increased proliferation in ovarian cancer cells with mir-182 overexpression, and less CD8 T lymphocytes infiltration with high mir-182 expressing ovarian cancers. These findings might contribute to the prognosis of ovarian cancer patients. The microRNA is therefore a candidate of new class targets for ovarian cancer.
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Report
(3 results)
Research Products
(16 results)
