The mechanism of carcinogenesis in ovarian clear cellcarcinoma and ovarian endometrioid carcinoma from endometriosis.
| Project/Area Number |
22791545
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Keio University |
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Principal Investigator |
AKAHANE Tomoko 慶應義塾大学, 医学部, 特任助教 (40398699)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 卵巣癌 / 卵巣明細胞癌 / 卵巣類内膜腺癌 / 子宮内膜症 / 癌化メカニズム / 発癌メカニズム / p53遺伝子 / p53蛋白 / 17番染色体 / 卵巣上皮細胞 / 間質細胞 / HNF1-β / 発癌機構 / 特異マーカー / 卵巣明細胞腺癌 / 異所性子宮内膜症 / Hepatocte Nuclear Factor 1β / 悪性転化機構 / 蛋白発現 / 腹腔内癌細胞 |
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| Research Abstract |
The origin of ovarian clear cell carcinoma, carcinogenesis from endometriosis. In this study, relation of Hepatocyte Nuclear Factor 1β(HNF1β) protein discovery and clinical pathology factor was considered in ovarian cancer patients. Variation of TP53gene
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Report
(4 results)
Research Products
(32 results)
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[Journal Article] The origin of stroma surrounding epithelial ovarian cancer cells.2013
Author(s)
AkahaneT, Hirasawa A, Tsuda H, Kataoka F, Ni shi mura S, TanakaH, Tominag E, Nomura H, ChiyodaT, IguchiY, Yamagami W, SusumuN, AokiD
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Journal Title
International Journal of Gynecological Pathology
Volume: 32(1)
Pages: 26-30
Related Report
Peer Reviewed
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[Journal Article] Lobular endocervical glandular hyperplasia and peritoneal pigmentation associated withPeutz-Jeghers syndrome due to a germline mutation of STK112012
Author(s)
Hirasawa A, Akahane T, Kobayashi Y, Masuda K, Banno K, Fujii T, Susumu N, Itsubo T, Kameyama K, Sugano K, Aoki D
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Journal Title
Annals of Oncology
Volume: 23(11)
Pages: 2990-2992
Related Report
Peer Reviewed
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[Journal Article] EGRI and FOSB gene expressions in cancer stroma are independent prognostic indicators for epithelial ovarian cancer receiving standard therapy2012
Author(s)
Kataoka F, Tsuda H, Arao T, Nishimura S, Tanaka H, Nomura H, Chiyoda T, Hirasawa A, Akahane T, Nishio H, Nishio K, Aoki D
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Journal Title
Genes Chromosomes Cancer
Volume: 51(3)
Pages: 300-12
Related Report
Peer Reviewed
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[Journal Article] Lobular endocervical glandular hyperplasia and peritoneal pigmentation associated with Peutz-Jeghers syndrome due to a germline mutation of STK112012
Author(s)
Hirasawa A, Akahane T, Kobayashi Y, Masuda K, Banno K, Fujii T, Susumu N, Itsubo T, Kameyama K, Sugano K, Aoki D
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Journal Title
Annlas of Oncology
Volume: 23(11)
Pages: 2990-2992
Related Report
Peer Reviewed
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