The mechanism of carcinogenesis in ovarian clear cellcarcinoma and ovarian endometrioid carcinoma from endometriosis.

• Project/Area Number: 22791545
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Obstetrics and gynecology
• Research Institution: Keio University
• Principal Investigator: AKAHANE Tomoko 慶應義塾大学, 医学部, 特任助教 (40398699)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 卵巣癌 / 卵巣明細胞癌 / 卵巣類内膜腺癌 / 子宮内膜症 / 癌化メカニズム / 発癌メカニズム / p53遺伝子 / p53蛋白 / 17番染色体 / 卵巣上皮細胞 / 間質細胞 / HNF1-β / 発癌機構 / 特異マーカー / 卵巣明細胞腺癌 / 異所性子宮内膜症 / Hepatocte Nuclear Factor 1β / 悪性転化機構 / 蛋白発現 / 腹腔内癌細胞

Research Abstract

The origin of ovarian clear cell carcinoma, carcinogenesis from endometriosis. In this study, relation of Hepatocyte Nuclear Factor 1β(HNF1β) protein discovery and clinical pathology factor was considered in ovarian cancer patients. Variation of TP53gene

Research Products

• [Journal Article] Establishment of a system for performing risk-reducing salpingo-oophorectomy for BRCA1 or BRCA2mutation carriers in Japan: Our challenges for the future. (2013)
  • Author(s): Hirasawa A, Masuda K, Akahane T, Tsuruta T, Banno K, Makita K, Susumu N, Sugano K, Kosaki K, Aoki D
  • Journal Title: Jpn J Clin Oncol Volume: 43(5) Pages: 515-519
  • Peer Reviewed
• [Journal Article] The origin of stroma surrounding epithelial ovarian cancer cells. (2013)
  • Author(s): AkahaneT, Hirasawa A, Tsuda H, Kataoka F, Ni shi mura S, TanakaH, Tominag E, Nomura H, ChiyodaT, IguchiY, Yamagami W, SusumuN, AokiD
  • Journal Title: International Journal of Gynecological Pathology Volume: 32(1) Pages: 26-30
  • Peer Reviewed
• [Journal Article] Lobular endocervical glandular hyperplasia and peritoneal pigmentation associated withPeutz-Jeghers syndrome due to a germline mutation of STK11 (2012)
  • Author(s): Hirasawa A, Akahane T, Kobayashi Y, Masuda K, Banno K, Fujii T, Susumu N, Itsubo T, Kameyama K, Sugano K, Aoki D
  • Journal Title: Annals of Oncology Volume: 23(11) Pages: 2990-2992
  • Peer Reviewed
• [Journal Article] Blood-Direct Invaderplus as a new method for genetic testing. (2012)
  • Author(s): Hirasawa A, Akahane T, Tanigawara Y, Aoki D
  • Journal Title: Technology report Parsonalized Medicine Volume: 9(6) Pages: 657-663
  • Peer Reviewed
• [Journal Article] EGRI and FOSB gene expressions in cancer stroma are independent prognostic indicators for epithelial ovarian cancer receiving standard therapy (2012)
  • Author(s): Kataoka F, Tsuda H, Arao T, Nishimura S, Tanaka H, Nomura H, Chiyoda T, Hirasawa A, Akahane T, Nishio H, Nishio K, Aoki D
  • Journal Title: Genes Chromosomes Cancer Volume: 51(3) Pages: 300-12
  • Peer Reviewed
• [Journal Article] Lobular endocervical glandular hyperplasia and peritoneal pigmentation associated with Peutz-Jeghers syndrome due to a germline mutation of STK11 (2012)
  • Author(s): Hirasawa A, Akahane T, Kobayashi Y, Masuda K, Banno K, Fujii T, Susumu N, Itsubo T, Kameyama K, Sugano K, Aoki D
  • Journal Title: Annlas of Oncology Volume: 23(11) Pages: 2990-2992
  • Peer Reviewed
• [Journal Article] Blood-direct InvaderPlus as a new method for genetic testing (2012)
  • Author(s): Hirasawa A, Akahane T, Tanigawara Y, Aoki D.
  • Journal Title: Journal of Personalized Medicine Volume: 9(6) Pages: 657-663
  • Peer Reviewed
• [Journal Article] 家系内の遺伝子検査が契機となり早期介入を行ったLynch症候群の一例 (2011)
  • Author(s): 中村加奈子, 平沢晃, 赤羽智子, 他7名
  • Journal Title: 東京産科婦人科学会会誌 Volume: 第60巻2号 Pages: 293-297
  • Peer Reviewed
• [Journal Article] Association between copy number variations of estorogen matabolism-related gene and bone mineral density in postmenopausal women of Japanese (2010)
  • Author(s): Hirasawa A, Akahane T, Makita K, Aoki D
  • Journal Title: Osteoporosis Int Volume: 21(5)
  • Peer Reviewed
• [Journal Article] A genome-wide association study identifies genetic variants in theCDKN2BASlocus associated with endometriosis in Japanese. (2010)
  • Author(s): Uno S, Zembutsu H, Hirasawa A, Takahashi A, Kubo M, Akahane T, Aoki D, Kamatani N, Hirata K, Nakamura Y
  • Journal Title: Nat Genet Volume: 42(8) Pages: 707-710
  • Peer Reviewed
• [Journal Article] Protein kinase C δand ηdifferently regulate the expression of loricrin and jun family proteins in human keratinocytes. (2010)
  • Author(s): Kamioka N, Akahane T, Kohno Y, Kuroki T, Iijima M, Honma I, Ohba M
  • Journal Title: Biophys Res Commun Volume: 394(1) Pages: 106-110
  • Peer Reviewed
• [Journal Article] A genome-wide association study identifies genetic variants in the CDKN2BAS locus associated with endometriosis in Japanese. (2010)
  • Author(s): S Uno, T Akahane, Y Nakamura, et al.
  • Journal Title: Nater Genetics. Volume: 42(8) Pages: 707-710
  • Peer Reviewed
• [Journal Article] Protein kinase C δ and η differently regulate the expression of loricrin and jun family proteins in human keratinocytes. (2010)
  • Author(s): N Kamioka, T Akahane, M Ohba, et al.
  • Journal Title: Biopilys Res Commun Volume: Mar 26;394(1) Pages: 106-110
  • Peer Reviewed
• [Journal Article] Association between copy number variations of estorogen matabolism-related gene and bone mineral density in postmenopausal women of Japanese. (2010)
  • Author(s): A Hirasawa, T Akahane, D Aoki, et al.
  • Journal Title: Osteoporosis Int Volume: 21(5)
  • Peer Reviewed
• [Journal Article] 両側卵巣摘出術施行例における骨代謝関連遺伝子の探索 (2010)
  • Author(s): 平沢晃、赤羽智子、牧田和也、青木大輔
  • Journal Title: Osteoporosis japan Volume: 18(3) Pages: 58-60
  • Peer Reviewed
• [Journal Article] ヒト三次元培養皮膚への遺伝子導入法の確立と表皮分化へのCキナーゼの関与 (2010)
  • Author(s): 上岡なぎさ, 本間生夫, 赤羽智子, 大場基, 他2名
  • Journal Title: 昭和医学会誌 Volume: 70(3) Pages: 253-262
  • NAID: 130000852909
  • Peer Reviewed
• [Presentation] 卵巣明細胞癌細胞株におけるHNF1B蛋白発現解析 (2012)
  • Author(s): 赤羽智子、冨永英一郎、平沢晃、青木大輔
  • Organizer: 第53回日本臨床細胞学会春季大会
  • Place of Presentation: 千葉県幕張
• [Presentation] 卵巣明細胞腺癌細胞におけるHNF1β蛋白発現解析 (2012)
  • Author(s): 赤羽智子 冨永英一郎 平沢 晃 青木大輔
  • Organizer: 第53回日本臨床細胞学会総会（春期季大会）
  • Place of Presentation: 幕張メッセ国際会議場
• [Presentation] 臨床的に癌性の体腔液貯留が疑われる症例の細胞診断学的検討 (2012)
  • Author(s): 冨永英一郎 赤羽智子 他5名
  • Organizer: 第53回日本臨床細胞学会総会（春期季大会）
  • Place of Presentation: 幕張メッセ国際会議場
• [Presentation] 上皮性卵巣癌におけるGNAS遺伝子の意義とその関連蛋白であるGsαの発現 (2012)
  • Author(s): 冨永英一郎 津田浩史 赤羽智子 他9名
  • Organizer: 第64回日本産科婦人科学会学術講演会
  • Place of Presentation: 神戸ポートピアホテル 神戸国際展示場
• [Presentation] 卵巣子宮内膜症からの明細胞腺癌への悪性分化機構の解明 (2011)
  • Author(s): 赤羽智子、関沢明彦, 岡井崇
  • Organizer: 第307回昭和医学会
  • Place of Presentation: 昭和大学1号館7階講堂(東京都)
  • Year and Date: 2011-05-28
• [Presentation] STK11遺伝子陽性を示し子宮頸部分葉状頸管過形成を合併したPeuz-Jegher症候群の1例 (2011)
  • Author(s): 赤羽智子、平沢 晃、小林佑介、鶴田智彦、阪埜浩司、藤井多久磨、進伸幸、菅野康吉、青木大輔
  • Organizer: 第50回臨床細胞学会秋期大会
  • Place of Presentation: 東京
• [Presentation] STK11遺伝子陽性を示し子宮頸部分葉状頸管過形成を合併したPeuz-Jegher症候群の1例 (2011)
  • Author(s): 赤羽智子、平沢晃, 他7名
  • Organizer: 第50回臨床細胞学会秋期大会
  • Place of Presentation: 京王プラザホテル(東京都)
• [Presentation] 抗がん剤のPK/PDとPGx～個別化投薬へ向けて がん臨床現場におけるファーマコゲノミクスの導入 (2010)
  • Author(s): 平沢 晃、赤羽智子、鶴田智彦、野村弘行、進 伸幸、小崎健次郎、谷川原祐介、青木大輔
  • Organizer: 第31回日本臨床薬理学会年会
  • Place of Presentation: 京都
  • Year and Date: 2010-12-02
• [Presentation] 抗がん剤のPK/PDとPGx～個別化投薬へ向けて がん臨床現場におけるファーマコゲノミクスの導入 (2010)
  • Author(s): 平沢晃、赤羽智子、青木大輔, 他5名
  • Organizer: 第31回日本臨床薬理学会年会(シンポジウム)
  • Place of Presentation: 京都
  • Year and Date: 2010-12-02
• [Presentation] 卵巣癌におけるHNF1B発現特異性と臨床病理学的因子との関連 (2010)
  • Author(s): 赤羽智子、冨永英一郎、平沢晃、進伸幸、青木大輔
  • Organizer: 第49回臨床細胞学会秋期大会
  • Place of Presentation: 神戸
• [Presentation] 卵巣明細胞腺癌におけるHNF1B発現特異性と臨床病理学的因子との関連に関する検討 (2010)
  • Author(s): 赤羽智子、冨永英一郎、平沢晃、進伸幸、青木大輔
  • Organizer: 第51回組織細胞化学会秋期大会
  • Place of Presentation: 東京
• [Presentation] Association between the UGT1A1 polymorphism, dyslipidemia and endometrial cancer risk. (2010)
  • Author(s): A Hirasawa, T Akahane, D Aoki, et al.
  • Organizer: European Human Genetics Conference
  • Place of Presentation: Gothenburg, Sweden
• [Presentation] 卵巣明細胞腺癌におけるHNF1B発現特異性と臨床病理学的因子との関連に関する検討 (2010)
  • Author(s): 赤羽智子、冨永英一郎、平沢晃、進伸幸、青木大輔
  • Organizer: 第51回 組織細胞化学会秋期大会
  • Place of Presentation: 東京
• [Presentation] 卵巣癌におけるHNF1B発現特異性と臨床病理学的因子との関連 (2010)
  • Author(s): 赤羽智子、冨永英一郎、平沢晃、進伸幸、青木大輔
  • Organizer: 第49回 臨床細胞学会秋期大会
  • Place of Presentation: 神戸
• [Remarks]
  • URL: http://k-ris.keio.ac.jp/Profiles/0150/0017635/profile.html
• [Remarks]
  • URL: http://k-ris.keio.ac.jp/Profiles/0150/0017635/profile.html