| Project/Area Number |
22791547
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Obstetrics and gynecology
|
|---|
| Research Institution | Keio University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
|---|
| Keywords | 子宮内膜 / シグナル伝達 / 脱落膜化 / 着床 / キナーゼ / 上皮間葉転換 |
|---|
| Research Abstract |
The aim of this research project was to explore the signaling molecules and pathways particularly involving SRC responsible for human endometrial function using proteomics methods. We attempted to construct an adenovirus vector expressing constitutively active SRC that was required as an essential material to accomplish this project, but we did not succeeded yet. Instead, we successfully prepared several research materials and tools such as reporter constructs, an immortalized human endometrial cell line, and in vivo model of human endometrial reconstitution. We also demonstrated that epithelial mesenchymal transition(EMT) involving N-cadherin played a role in human endometrial epithelial cell function.
|
