Proteomics-based exploration of signaling molecules responsible for human endometrial function
Project/Area Number |
22791547
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Obstetrics and gynecology
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Research Institution | Keio University |
Principal Investigator |
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Project Period (FY) |
2010 – 2011
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Project Status |
Completed (Fiscal Year 2011)
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Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
Keywords | 子宮内膜 / シグナル伝達 / 脱落膜化 / 着床 / キナーゼ / 上皮間葉転換 |
Research Abstract |
The aim of this research project was to explore the signaling molecules and pathways particularly involving SRC responsible for human endometrial function using proteomics methods. We attempted to construct an adenovirus vector expressing constitutively active SRC that was required as an essential material to accomplish this project, but we did not succeeded yet. Instead, we successfully prepared several research materials and tools such as reporter constructs, an immortalized human endometrial cell line, and in vivo model of human endometrial reconstitution. We also demonstrated that epithelial mesenchymal transition(EMT) involving N-cadherin played a role in human endometrial epithelial cell function.
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Report
(3 results)
Research Products
(24 results)
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[Presentation] Possible involvement of UDP-glucose and its recepter P2RY14 in embryo implantation2011
Author(s)
Toru Arase, Tetsuo Maruyama, Hiroshi Uchida, Kaoru Miyazaki, Hideyuki Oda, Sayaka Uchida-Nishikawa, Maki Kagami, Akiko Yamasaki, Kayoko Tamaki, Yasunori Yoshimura
Organizer
27th European Society of Human Reproduction & Embryology(ESHRE)
Place of Presentation
Stockholm, Sweden
Related Report
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[Presentation] Identification of a novel endometrial gene associated with menstruation, endometriosis and adenomyosis2011
Author(s)
Tetsuo Maruyama, Takashi Kajitani, Hideyuki Oda, Kaoru Miyazaki, Sayaka Uchida, Akiko Yamasaki, Hironori Asada, Hiroshi Uchida, Yasunori Yoshimura
Organizer
11th World Congress on Endometriosis (WCE)
Place of Presentation
Montpellier, France
Related Report
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[Presentation] Possible involvement of UDP-glucose and its recepter P2RY14 in embryo implantation2011
Author(s)
Toru Arase, Tetsuo Marayama, Hiroshi Uchida, Kaoru Miyazaki, Hideyuki Oda, Sayaka Uchida-Nishikawa, Maki Kagami, Akiko Yamasaki, Kayoko Tamaki, Yasunori Yoshimura
Organizer
27th European Society of Human Reproduction & Embryology (ESHRE)
Place of Presentation
Stockholm, Sweden
Related Report
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[Presentation] CD93 and CD31 as possible candidate markers for human endometrial stem/progenitor cells2011
Author(s)
Kaoru Miyazaki, Takashi Kajitani, Hirotaka Masuda, Toshio Hamatani, Hideyuki Oda, Akiko Yamasaki, Sayaka Nishikawa-Uchida, Hiroshi Uchida, Yasunori Yoshimura, Tetsuo Maruyama
Organizer
9th International Society for Stem Cell Research (ISSCR)
Place of Presentation
Tronto, Ontario Canada
Related Report
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[Presentation] Possible involvement of endometrial stem/progenitor cells in the pathogenesis of endocetriosis2010
Author(s)
Tetsuo Maruyama, Hirotaka Masuda, Takashi Nagashima, Takashi Kajitani, Masanori Ono, Sayaka Nishikawa-Uchida Hideyuki Oda, Kaoru Miyazaki, Toru Arase, Maki Kagami, Hiroshi Uchida Hironori Asada, Yasunori Yoshimura
Organizer
1st Asian Conference on Endometriosis(ACE)
Place of Presentation
Shanghai, China
Related Report
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[Presentation] Possible involvement of endometrial stem/progenitor cells in the pathogenesis of endocetriosis.2010
Author(s)
Tetsuo Maruyama, Hirotaka Masuda, Takashi Nagashima, Takashi Kajitani, Masanori Ono, Sayaka Nishikawa-Uchida, Hideyuki Oda, Kaoru Miyazaki, Toru Arase, Maki Kagami, Hiroshi Uchida, Hironori Asada, Yasunori Yoshimura
Organizer
The First Asian Conference on Endometriosis(ACE)
Place of Presentation
Shanghai, China(招請講演)
Related Report
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[Presentation] Prospective isolation and functional analysis of stem/progenitor cells from the human uterine myometrium.2010
Author(s)
Masanori Ono, Tetsuo Maruyama, Takashi Kajitani, Hiroshi Uchida, Hideyki Oda, Sayaka Nishikawa-Uchida, Kaoru Miyazaki, Takashi Nagashima, Hirotaka Masuda, Hideyuki Okano, Yumi Matsuzaki, Yasunori Yoshimura
Organizer
8th International Society for Stem Cell Research(ISSCR)
Place of Presentation
San Francisco, CA USA
Related Report
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[Presentation] Cell surface marker-based isolation and function and functional analysis of human myometrial stem cells.2010
Author(s)
Masanori Ono, Tetsuo Maruyama, Hiroshi Uchida, Hideyuki Oda, Sayaka Nishikawa, Maki Kagami, Toru Arase, Takashi Nagashima, Hirotaka Masuda, Hironori Asada, Daisuke Aoki, Yasunori Yoshimura
Organizer
第62回日本産科婦人科学会International Session
Place of Presentation
東京
Related Report