Genetic expression involving the cancer-stroma interaction and its clinical significance in endometrial cancer

• Project/Area Number: 22791548
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Obstetrics and gynecology
• Research Institution: Keio University
• Principal Investigator: KATAOKA Fumio 慶應義塾大学, 医学部, 助教 (40306824)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2010: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
• Keywords: 癌 / マイクロアレイ / 生体分子 / 生物分子 / マクロアレイ

Research Abstract

Endometrial cancer and stromal tissues were microdissected and separate microarray analysis were performed using GeneChip. By microarray analysis, 11 candidate genes associated with disease progression were identified, and these genes may be associated with cancer-stroma interaction in endometrial cancer.

Research Products

• [Journal Article] EGR1 and FOSB gene expressions in cancer stroma are independent prognostic indicators for epithelial ovarian cancer receiving standard therapy (2012)
  • Author(s): Kataoka F, Tsuda H, Arao T, Nishimura S, Tanaka H, Nomura H, Chiyoda T, Hirasawa A, Akahane T, Nishio H, Nishio K, Aoki D
  • Journal Title: Genes Chromosomes Cancer Volume: 51(3) Pages: 300-12
  • Peer Reviewed
• [Journal Article] Overexpression of cofilin1 can predict the progression free survival on epithelial ovarian cancer (2011)
  • Author(s): Nishimura S, Tsuda H, Kataoka F, Arao T, Nomura H, Chiyoda T, Tanaka H, Susumu N, Nishio K, Aoki D
  • Journal Title: Human Pathol Volume: 4 Pages: 516-519
  • Peer Reviewed
• [Journal Article] The expression of hypoxia inducible 2(HIG2) protein in the uterine cancer (2011)
  • Author(s): Nishimura S, Tsuda H, Nomura H, Kataoka F, Chiyoda T, Tanaka H, Tanaka K, Susumu N, Aoki D
  • Journal Title: Eur J Gynaecol Oncol Volume: XXXII Pages: 146-149
  • Peer Reviewed
• [Journal Article] Amplification of GNAS may be an independent, qualitative, and reproducible biomarker to predict progression-free survival in epithelial ovarian cancer (2010)
  • Author(s): Tominaga E, Tsuda H, Arao T, Nishimura S, Takano M, Kataoka F, Nomura H, Hirasawa A, Aoki D, Nishio K
  • Journal Title: Gynecol Oncol Volume: 118(2) Pages: 160-6
  • Peer Reviewed
• [Presentation] 発現解析による子宮体癌の再発予測モデルの開発 (2011)
  • Author(s): 津田浩史, 井口蓉子, 片岡史夫, 野村弘行, 田中英雄, 千代田達幸, 平沢晃, 進伸幸, 青木大輔
  • Organizer: 第31回日本分子腫瘍マーカー研究会
  • Place of Presentation: 名古屋,名古屋国際会議場
  • Year and Date: 2011-10-02
• [Presentation] 新しい細胞情報解析システムの開発-治療成績の向上を目指して- (2011)
  • Author(s): 津田浩史
  • Organizer: 第63回日本産科婦人科学会学術集会
  • Place of Presentation: 大阪,リーガロイヤルホテル大阪および大阪国際会議場
  • Year and Date: 2011-08-28
• [Presentation] 卵巣癌間質の遺伝子発現解析を用いた新規バイオマーカーの探索癌間質のEGR-1発現は上皮性卵巣癌の予後予測因子である (2011)
  • Author(s): 片岡史夫, 津田浩史, 野村弘行, 千代田達幸, 赤羽智子, 平沢晃, 進伸幸, 青木大輔, 吉村泰典
  • Organizer: 第63回日本産科婦人科学会学術集会
  • Place of Presentation: 大阪,リーガロイヤルホテル大阪および大阪国際会議場
  • Year and Date: 2011-08-28
• [Presentation] 新しい細胞情報解析システムの開発-治療成績の向上を目指して- (2011)
  • Author(s): 津田浩史
  • Organizer: 第63回日本産科婦人科学会学術集会
  • Place of Presentation: リーガルロイヤルホテル大阪・大阪国際会議場(大阪府)
  • Year and Date: 2011-08-28
• [Presentation] 間質におけるVimentin陽性となる紡錘形細胞のEGR-1発現は,上皮性卵巣癌の予後規定因子である (2010)
  • Author(s): 片岡史夫, 他
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪,リーガロイヤルホテル大阪および大阪国際会議場
  • Year and Date: 2010-09-23
• [Presentation] EGR-1 expression of vimentin-positive spindle-shaped cells in stroma is a prognostic indicator of ovarian cancer. (2010)
  • Author(s): 片岡史夫
  • Organizer: 第69回 日本癌学会
  • Place of Presentation: 大阪
  • Year and Date: 2010-09-23
• [Presentation] EGR-1 gene expression of fibroblast in cancer stroma isa prognostic incicator of the epithelial ovarian cancer receiving standard therapy (2010)
  • Author(s): Kataoka F, et al
  • Organizer: Sixth International Symposium on Hormonal Oncogenesis
  • Place of Presentation: 千葉, SHERATON GRANDE TOKYO BAY HOTEL
  • Year and Date: 2010-09-14
• [Presentation] 腫瘍間質のVimentin陽性細胞のEGR-1発現は上皮性卵巣癌の予後と相関する (2010)
  • Author(s): 片岡史夫, 津田浩史, 西村貞子, 冨永英一郎, 野村弘行, 千代田達幸, 平沢晃, 鈴木淳, 進伸幸, 青木大輔
  • Organizer: 第48回日本婦人科腫瘍学会学術講演会
  • Place of Presentation: つくば,つくば国際会議場
  • Year and Date: 2010-07-08
• [Remarks]
  • URL: http://www.obgy.med.keio.ac.jp/04research/06gy2.html