| Project/Area Number |
22791549
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Obstetrics and gynecology
|
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| Research Institution | Juntendo University |
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Principal Investigator |
SUGA Shin 順天堂大学, 医学部, 助教 (70445542)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
KATO Kiyoko 順天堂大学, 医学研究科, 准教授 (10253527)
|
|---|
| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 子宮内膜 / 子宮体癌幹細胞 / side population ALDH1 / 子宮体癌 / 幹細胞 / ALDH1 / side population細胞 |
|---|
| Research Abstract |
Primary cultured cells derived from normal human endometrium contained ALDH1-high population. There was no difference of expression of HER2 between ALDH-high cells and. low cells. ALDH1 activity was enhanced in endometrial cancer stem cells compared with that in non-stem cells. Introduction of dbpC to endometrial cancer cells enhanced subpopulations of stem cells as well as the level of ALDH1 ecpression. These results demonstrated that ALDH1 was a candidate for marker of endometrial cancer stem cells.
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