| Project/Area Number |
22791550
|
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Obstetrics and gynecology
|
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| Research Institution | Keio University (2011)
Tokai University (2010) |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | ステロイド産生 / ミトコンドリア / OSAP / アポトーシス / Ovary Specific Acid Protein / 副腎皮質細胞 / 胎児副腎 |
|---|
| Research Abstract |
Our results indicate that the mitochondrial protein OSAP is abundantly expressed in steroidogenic tissues with a few exceptions. The results also suggest that OSAP is involved in steroidogenesis. However, our findings point to a permissive role for OSAP in steroidogenesis rather than a regulatory role because OSAP expression was not stimulated by a cAMP analog. Thus, we speculate that this protein could be involved in insuring optimal steroidogenesis through maintaining mitochondrial abundance and/or function. Further studies are warranted to substantiate this postulated role for OSAP in steroidogenic cells.
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