Regulation of the expression of FGFR2IIIc isoform, a novel therapeutic strategy for cervical cancer

• Project/Area Number: 22791552
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Obstetrics and gynecology
• Research Institution: Nippon Medical School
• Principal Investigator: PENG Wei-Xia 日本医科大学, 医学部, 助教 (00535700)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000); Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: FGFR2IIIc / 子宮頸癌 / ERK MAPKシグナル伝達経路 / AKT PI3Kシグナル伝達経路

Research Abstract

Fibroblast growth factor receptor 2(FGFR2) is noted as a molecular target for cancer treatment in patients with FGFR2 mutation or gene amplification. In this study, we investigated the expression and role of FGFR2IIIc, an isoform of FGFR2, in cervical carcinoma. The expression of FGFR2IIIc was highly detected in cervical cancer cells. And not only the ERK signaling pathway, but the AKT signaling pathway are involved in the progression of cervical carcinoma. Furthermore, the expression of FGFR2IIIc in endometrial lesions showed the same expression pattern with cervical lesions. These findings suggest that FGFR2IIIc plays important roles in carcinogenesis of both cervical cancer and endometrioid cancer. FGFR2IIIc may serve as a novel molecular target for uterus cancer therapy.

Research Products

• [Journal Article] Overexpressed fibroblast growth factor receptor 2 in the invasive front of colorectal cancer as a potential therapeutic target of colorectal cancer (2011)
  • Author(s): Mastuda Y, Ishiwata T, Yamahatsu K, Kawahara K, Hagio M, Peng WX, Yamamoto T, Nakazawa N, Seya T, Ohaki Y, Naito Z.
  • Journal Title: Cancer Letters Volume: 309 Issue: 2 Pages: 209-19
  • DOI: 10.1016/j.canlet.2011.06.009
  • Peer Reviewed
• [Journal Article] Morphological and cytoskeletal alterations of nervous system tumor cells with different culturing methods (2011)
  • Author(s): Mastuda Y, Kawamoto Y, Teduka K, Peng WX, Yamamoto T, Ishiwata T, Naito Z.
  • Journal Title: Int J Oncol Volume: 38 Issue: 5 Pages: 1253-8
  • DOI: 10.3892/ijo.2011.945
  • Peer Reviewed
• [Presentation] 振り子状の形態を呈した肝臓血管筋脂肪腫の1例 (2011)
  • Author(s): 梶尾円香, 彭為霞, 井内亜美, 松田陽子, 石渡俊行, 恩田宗彦, 山本哲志, 新井悟, 大秋美治, 内藤善哉
  • Organizer: 第100回日本病理学会総会
  • Place of Presentation: 神奈川
  • Year and Date: 2011-04-30
• [Presentation] 線維芽細胞増殖因子受容体(FGFR2)を標的とした膵癌治療の研究 (2011)
  • Author(s): 石渡俊行, 松田陽子, 上田純志, 山本哲志, 彭為霞, 川原清子, 内田英二, Murray Korc, 内藤善哉
  • Organizer: 第100回日本病理学会総会
  • Place of Presentation: 神奈川
  • Year and Date: 2011-04-30
• [Presentation] 膵癌特異分泌型lumicanの細胞増殖への関与 (2011)
  • Author(s): 山本哲志, 松田陽子, 川原清子, 彭為霞, 内藤善哉, 石渡俊行
  • Organizer: 第100回日本病理学会総会
  • Place of Presentation: 神奈川
  • Year and Date: 2011-04-28
• [Presentation] 子宮頸部異形成および子宮頸癌におけるNestinの発現 (2011)
  • Author(s): 佐藤杏月、石渡俊行、山本哲志、河本陽子、彭為霞、松田陽子、恩田宗彦、朝倉啓文、竹下俊行、内藤善哉
  • Organizer: 第100回日本病理学会総会
  • Place of Presentation: 神奈川
  • Year and Date: 2011-04-28