| Project/Area Number |
22791557
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Ehime University (2011)
Kawasaki Medical School (2010) |
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Principal Investigator |
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| Research Collaborator |
TONE Shigenobu 川崎医科大学, 医学部, 准教授 (70211399)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 生殖医学 / 胎児-母体間免疫 / トリプトファン / IDO / 絨毛膜羊膜炎 / indoleamine 2,3-dioxygnase / 早産 / インドールアミン酸素添加酵素 / 胎盤 / 絨毛膜羊膜炎(CAM) / 免疫寛容 / プロスタグランジン / Western blot法 |
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| Research Abstract |
In this study, we examined protein expression of indoleamine 2, 3-dioxygenase(IDO) in the placenta of the pregnant woman and an amnion, chorion, the decidua, and examined association with chorioamniotis(CAM) and the premature birth. The specimen intended for 191 pregnant women delivered of in a hospital attached to Kawasaki Medical School. As a result, in a placenta sample of the early pregnancy, the IDO manifestation showed low level at approximately 0. 77 times from control group. Also, after comparing it with the control group, the IDO expression showed approximately 2. 29 times high level in the placenta sample of the patients with a history of CAM. Because CAM was an abortive main cause, it was suggested that IDO expression showed correlation about the premature birth.
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