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activation of micro-RNA in head and neck cancer cell

Research Project

Project/Area Number 22791561
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Otorhinolaryngology
Research InstitutionHokkaido University

Principal Investigator

KANO Satoshi  北海道大学, 大学院・医学研究科, 助教 (00374421)

Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords頭頸部癌 / マイクロRNA / TRIM32
Research Abstract

has-miR-134 was identified as a micro RNA specifically binding to TRIM32. has-miR-134 has been reported to express highly in tongue cancer. VEGF-A and ABCC1 were considered as the target gene of has-miR-134. However, we could not confirm an activation of has-miR-134 by TRIM32. Furthermore, we could not confirm an activation and change in the expression level of has-miR-134 in cell lines overexpressed or knocked down TRIM32.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (43 results)

All 2012 2011 2010 Other

All Journal Article (24 results) (of which Peer Reviewed: 20 results) Presentation (17 results) Book (2 results)

  • [Journal Article] Salvage surgery for recurrent oropharyngeal cancer after chemoradiotherapy.2012

    • Author(s)
      Kano S, Homma A, Hayashi R, Kawabata K,Yoshino K
    • Journal Title

      Int J Clin Oncol

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Improved survival of Japanese patients with humanpapillomavirus-positive oropharyngeal squamous cell carcinoma.2012

    • Author(s)
      Mizumachi T, Kano S, Sakashita T, Hatakeyama H, Suzuki S
    • Journal Title

      Int J Clin Oncol

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Combined modality therapy for laryngeal cancer with superselective intra-arterial cisplatin infusion and concomitant radiotherapy2012

    • Author(s)
      Taki S, Homma A, Suzuki F, Oridate N, Hatakeyama H, Mizumachi T, Kano S
    • Journal Title

      Int J Clin Oncol

      Volume: 17 Pages: 441-446

    • NAID

      10031144330

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of nodal response after intra-arterial chemoradiation for node-positive head and neck cancer.2012

    • Author(s)
      Sakashita T, Homma A, Oridate N, Hatakeyama H, Kano S
    • Journal Title

      Eur Arch Otorhinolaryngol

      Volume: 269 Pages: 1671-1676

    • NAID

      120005946626

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Platinum concentration in sentinel lymph nodes after preoperativeintra-arterial cisplatin chemotherapy targeting primary tongue cancer.2012

    • Author(s)
      Sakashita T, Homma A, Oridate N, Suzuki S, Hatakeyama H, Kano S
    • Journal Title

      Acta Otolaryngol

      Volume: 132 Pages: 1121-1125

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] ESD後に反復感染をきたし喉頭全摘に至った1症例.2012

    • Author(s)
      加納里志,折舘伸彦,福田諭
    • Journal Title

      日気食会

      Volume: 63 Pages: 331-336

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 切除可能T3、T4上顎洞扁平上皮癌における手術の位置付け-当院における治療戦略.2012

    • Author(s)
      本間明宏,折舘伸彦,鈴木清護,鈴木章之,畠山博充,加納里志他
    • Journal Title

      耳鼻

      Volume: 58

    • NAID

      130004555582

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 喉頭癌T3症例の治療成績の検討.2012

    • Author(s)
      水町貴諭,折舘伸彦,本間明宏,坂下智博,加納里志
    • Journal Title

      頭頸部外科

      Volume: 22 Pages: 317-321

    • NAID

      10031170514

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 頭頸部癌化学放射線療法における経管栄養の役割に関する検討.2012

    • Author(s)
      倉本倫之介,折舘伸彦,本間明宏,及川敬太,藤田香,鈴木清護,畠山博充,加納里志
    • Journal Title

      嚥下医学

      Volume: 1 Pages: 359-363

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 第13回耳鼻咽喉科手術支援システム・ナビ研究会早期舌癌におけるセンチネルリンパ節の領域分布に関する検討.2012

    • Author(s)
      坂下智博,本間明宏,折舘伸彦,鈴木清護,畠山博充,加納里志
    • Journal Title

      耳展

      Volume: 55 Pages: 364-368

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 【Best articles of the year】舌根癌における放射線同時併用超選択的動注化学療法2012

    • Author(s)
      加納里志,本間明宏,折舘伸彦,鈴木章之,畠山博充
    • Journal Title

      北海道医誌

      Volume: 87 Pages: 208-208

    • Related Report
      2012 Final Research Report
  • [Journal Article] 【Best articles of the year】口腔癌における超選択的シスプラチン動注化学療法後のセンチネルリンパ節内プラチナ濃度測定.2012

    • Author(s)
      坂下智博,本間明宏,折舘伸彦,鈴木清護,畠山博充,加納里志
    • Journal Title

      北海道医誌

      Volume: 7 Pages: 261-261

    • Related Report
      2012 Final Research Report
  • [Journal Article] Salvage surgery for recurrent oropharyngeal cancer after chemoradiotherapy.2012

    • Author(s)
      Kano S, Homma A, Hayashi R, Kawabata K, Yoshino K, et al.
    • Journal Title

      Int J Clin Oncol

      Volume: Epub ahead of print Issue: 5 Pages: 817-823

    • DOI

      10.1007/s10147-012-0449-x

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Improved survival of Japanese patients with human papillomavirus-positive oropharyngeal squamous cell carcinoma2012

    • Author(s)
      Mizumachi T, Kano S, Sakashita T, Hatakeyama H, Suzuki S, Homma A, Oridate N, Fukuda S
    • Journal Title

      Int J Clin Oncol

      Volume: online 31 Issue: 5 Pages: 0-0

    • DOI

      10.1007/s10147-012-0469-6

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Combined modality therapy for laryngeal cancer with superselective intra-arterial cisplatin infusion and concomitant radiotherapy.2012

    • Author(s)
      ④ Taki S, Homma A, Suzuki F, Oridate N, Hatakeyama H, Mizumachi T, Kano S, et al.
    • Journal Title

      Int J Clin Oncol

      Volume: 17 Issue: 5 Pages: 441-446

    • DOI

      10.1007/s10147-011-0308-1

    • NAID

      10031144330

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of nodal response after intra-arterial chemoradiation for node-positive head and neck cancer2012

    • Author(s)
      Sakashita T, Homma A, Oridate N, Hatakeyama H, Kano S, Mizumachi T, Fukuda S
    • Journal Title

      Eur Arch Otorhinolaryngol

      Volume: 269 Issue: 6 Pages: 1671-1676

    • DOI

      10.1007/s00405-011-1814-5

    • NAID

      120005946626

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Platinum concentration in sentinel lymph nodes after preoperative intra-arterial cisplatin chemotherapy targeting primary tongue cancer2012

    • Author(s)
      Sakashita T, Homma A, Oridate N, Suzuki S, Hatakeyama H, Kano S, Mizumachi T, Yoshida D, Fujima N, Fukuda S
    • Journal Title

      Acta Otolaryngol

      Volume: 132 Issue: 10 Pages: 1121-1125

    • DOI

      10.3109/00016489.2012.680494

    • NAID

      10031131102

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ESD後に反復感染をきたし喉頭全摘に至った1症例.2012

    • Author(s)
      加納里志, 折舘伸彦, 福田 諭.
    • Journal Title

      日気食会報

      Volume: 63 Pages: 331-336

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 切除可能T3、T4上顎洞扁平上皮癌における手術の位置付け—当院における治療戦略—.2012

    • Author(s)
      本間明宏, 折舘伸彦, 鈴木清護, 鈴木章之, 畠山博充, 加納里志他
    • Journal Title

      耳鼻

      Volume: 58

    • NAID

      130004555582

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] <第13回耳鼻咽喉科手術支援システム・ナビ研究会>早期舌癌におけるセンチネルリンパ節の領域分布に関する検討.2012

    • Author(s)
      坂下智博, 本間明宏, 折舘伸彦, 鈴木清護, 畠山博充, 加納里志他
    • Journal Title

      耳展

      Volume: 55 Pages: 364-368

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 【Best articles of the year】舌根癌における放射線同時併用超選択的動注化学療法.2012

    • Author(s)
      加納里志, 本間明宏, 折舘伸彦, 鈴木章之, 畠山博充他
    • Journal Title

      北海道医誌

      Volume: 87 Pages: 208-208

    • Related Report
      2012 Annual Research Report
  • [Journal Article] 【Best articles of the year】口腔癌における超選択的シスプラチン動注化学療法後のセンチネルリンパ節内プラチナ濃度測定.2012

    • Author(s)
      坂下智博, 本間明宏, 折舘伸彦, 鈴木清護, 畠山博充, 加納里志他
    • Journal Title

      北海道医誌

      Volume: 7 Pages: 261-261

    • Related Report
      2012 Annual Research Report
  • [Journal Article] Superselective arterial cisplatin infusion with concomitant radiation therapy for base of tongue cancer.2011

    • Author(s)
      Kano S
    • Journal Title

      Oral Oncology

      Volume: 47 Pages: 665-670

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Superselective arterial cisplatin infusion with concomitant radiation therapy for base of tongue cancer2011

    • Author(s)
      Satoshi Kano
    • Journal Title

      Oral Oncology

      Volume: 47 Issue: 7 Pages: 665-670

    • DOI

      10.1016/j.oraloncology.2011.04.015

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] Matched-pair analysis in patients with advanced oropharyngeal cancer: surgery versus concurrent chemoradiotherapy.2012

    • Author(s)
      Kano S
    • Organizer
      第8回国際頭頸部癌学会(8th International Conference on Head and Neck Cancer)
    • Place of Presentation
      Metro Toronto Convention Centre(Toronto,Canada)
    • Year and Date
      2012-07-24
    • Related Report
      2012 Final Research Report
  • [Presentation] 原発不明頸部リンパ節転移におけるp16とヒト乳頭腫ウイルスの解析.2012

    • Author(s)
      加納里志
    • Organizer
      第36回日本頭頸部癌学会
    • Place of Presentation
      島根県民会館(松江市)
    • Year and Date
      2012-06-07
    • Related Report
      2012 Final Research Report
  • [Presentation] 照射後の異時重複下咽頭癌に対するESD後に反復感染をきたし喉頭全摘に至った一症例.2011

    • Author(s)
      加納里志
    • Organizer
      第63回日本気管食道科学会総会ならびに学術講演会
    • Place of Presentation
      名古屋東急ホテル(名古屋市)
    • Year and Date
      2011-11-11
    • Related Report
      2012 Final Research Report
  • [Presentation] 照射後の異時重複下咽頭癌に対するESD後に反復感染をきたし喉頭全摘に至った一症例2011

    • Author(s)
      加納里志
    • Organizer
      第63回日本気管食道科学会総会ならびに学術講演会
    • Place of Presentation
      名古屋東急ホテル(名古屋市)
    • Year and Date
      2011-11-11
    • Related Report
      2011 Annual Research Report
  • [Presentation] 唾液腺悪性腫瘍におけるEGFR,HER2,c-KITの発現解析.2011

    • Author(s)
      加納里志
    • Organizer
      第35回頭頸部癌学会
    • Place of Presentation
      ウインクあいち愛知(産業労働センター)(名古屋市)
    • Year and Date
      2011-06-09
    • Related Report
      2012 Final Research Report
  • [Presentation] 唾液腺悪性腫瘍におけるEGFR,HER2,c-KITの発現解析2011

    • Author(s)
      加納里志
    • Organizer
      第35回頭頸部癌学会
    • Place of Presentation
      ウインクあいち愛知(産業労働センター)(名古屋市)
    • Year and Date
      2011-06-09
    • Related Report
      2011 Annual Research Report
  • [Presentation] TRIM32 facilitates cell growth, migration and anti-apoptosis.2011

    • Author(s)
      Kano S
    • Organizer
      第102回米国癌研究会議(AACR 102nd Annual Meeting)
    • Place of Presentation
      Orange County Convention Center(USA)
    • Year and Date
      2011-04-05
    • Related Report
      2012 Final Research Report
  • [Presentation] TRIM32 facilitates cell growth, migration and anti-apoptosis2011

    • Author(s)
      Satoshi Kano
    • Organizer
      第102回米国癌研究会議(AACR 102nd Annual Meeting)
    • Place of Presentation
      Orange County Convention Center (USA)
    • Year and Date
      2011-04-05
    • Related Report
      2011 Annual Research Report
  • [Presentation] 中咽頭側壁・前壁癌に対する放射線化学療法の検討.2010

    • Author(s)
      加納里志
    • Organizer
      第23回日本口腔・咽頭科学会総会学術講演会
    • Place of Presentation
      京王プラザホテル(東京都)
    • Year and Date
      2010-09-17
    • Related Report
      2012 Final Research Report
  • [Presentation] 中咽頭側壁・前壁癌に対する放射線科学療法の検討2010

    • Author(s)
      加納里志
    • Organizer
      第23回日本口腔・咽頭科学会総会学術講演会
    • Place of Presentation
      京王プラザホテル(東京都)
    • Year and Date
      2010-09-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] Concurrent chemoradiotherapy for oropharyngeal cancer: A retrospective comparison of superselective high-dose cisplatin infusion and systemic chemotherapy.2010

    • Author(s)
      加納里志
    • Organizer
      IFHNOS(第4回国際頭頸部腫瘍学会議)
    • Place of Presentation
      ロッテホテル(ソウル)
    • Year and Date
      2010-06-17
    • Related Report
      2012 Final Research Report
  • [Presentation] Concurrent chemoradiotherapy for oropharyngeal cancer : A retrospective comparison of superselective high-dose cisplatin infusion and systemic chemotherapy.2010

    • Author(s)
      加納里志
    • Organizer
      IFHNOS(第4回国際頭頸部腫瘍学会議)
    • Place of Presentation
      ロッテホテル(ソウル)韓国
    • Year and Date
      2010-06-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] 原発不明頸部リンパ節転移におけるp16とヒト乳頭腫ウイルスの解析

    • Author(s)
      加納里志
    • Organizer
      第36回日本頭頸部癌学会
    • Place of Presentation
      島根県民会館 (松江市殿町158)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Matched-pair analysis in patients with advanced oropharyngeal cancer: surgery versus concurrent chemoradiotherapy

    • Author(s)
      Kano S
    • Organizer
      8th International Conference on Head and Neck Cancer
    • Place of Presentation
      Metro Toronto Convention Centre(Toronto,Canada)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 唾液腺癌におけるHER2の発言解析.

    • Author(s)
      加納里志, 折舘伸彦, 本間明宏, 鈴木清護他.
    • Organizer
      第92回北海道医学大会腫瘍系分科会・第106回北海道癌談話会例会
    • Place of Presentation
      北大医学部学友会館フラテ(札幌市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 当科における唾液腺癌治療の現状と今後の治療戦略.

    • Author(s)
      加納里志
    • Organizer
      第25回日本耳鼻咽喉科学会北海道ブロック講演会
    • Place of Presentation
      北大臨床大講堂(札幌市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 高悪性度唾液腺癌に対する治療戦略

    • Author(s)
      加納里志
    • Organizer
      北海道耳鼻咽喉科サマーセミナー
    • Place of Presentation
      北大臨床大講堂(札幌市)
    • Related Report
      2012 Annual Research Report
  • [Book] 特集嗅神経芽細胞腫2010

    • Author(s)
      加納里志
    • Publisher
      東京医学社
    • Related Report
      2012 Final Research Report
  • [Book] JOHNS Vol.26 No.32010

    • Author(s)
      加納里志
    • Total Pages
      2
    • Publisher
      東京医学社
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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