Vulnerability of neurons in the prepositus hypoglossi nucleus against transient ischemia.

• Project/Area Number: 22791568
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Otorhinolaryngology
• Research Institution: Gunma University
• Principal Investigator: SHINO Masato 群馬大学, 医学部, 助教 (20550015)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2010: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
• Keywords: 舌下神経前位核 / 虚血 / 内側前庭神経核 / パッチクランプ / 内族前庭神経核 / 自発発火 / 一過性過分極

Research Abstract

The neurons in the medial vestibular and the prepositus hypoglossi nucleus are hyperpolarized due to transient outward potassium current through KATP channels during transient ischemia. This mechanism is thought to be a self-defense system which enables to prevent neurons from ischemic injury.

Research Products

• [Journal Article] Characterization of ionic channels underlying the specific firing pattern of a novel neuronal subtype in the rat prepositus hypoglossi nucleus (2012)
  • Author(s): Saito Y, Shino M, Yanagawa Y.
  • Journal Title: Neurosci Res Volume: 73(1) Pages: 32-41
  • Peer Reviewed
• [Journal Article] Characterization of ionic channels underlying the specific firing pattern of a novel neuronal subtype in the rat prepositus hypoglossi nucleus (2012)
  • Author(s): Saito Y, Shino M, Yanagawa Y
  • Journal Title: Neuroscience Research Volume: 73 Pages: 32-41
  • Peer Reviewed
• [Journal Article] Electrophysiological characteristics of inhibitory neurons of the prepositus hypoglossi nucleus as analyzed in Venus-expressing transgenic rats (2011)
  • Author(s): Shino M, Kaneko R, Yanagawa Y, Kawaguchi Y, Saito Y.
  • Journal Title: Neuroscience Volume: 197 Pages: 89-98
  • Peer Reviewed
• [Journal Article] Angiotens in II receptor blocker-induced angioedema in the oral floor and epiglottis (2011)
  • Author(s): Shino M, Takahashi K, Murata T, Iida H, Yasuoka Y, Furuya N.
  • Journal Title: Am J Otolaryngol Volume: 32(6) Pages: 624-6
  • Peer Reviewed
• [Journal Article] Angiotensin II receptor blocker-induced angioedema in the oral floor and epiglottis. (2011)
  • Author(s): Shino M, et al.
  • Journal Title: American Journal of Otolaryngology Volume: (Epub ahead of print)
  • Peer Reviewed
• [Presentation] 虚血による内側前庭神経核ニューロンの一過性過分極を説明するATP感受性Kチャネル由来の外向きカリウム電流 (2011)
  • Author(s): 紫野正人, 高安幸弘, 高橋克昌
  • Organizer: 第70回日本メマイ平衡医学会総会・学術講演会
  • Place of Presentation: 幕張メッセ(千葉)
  • Year and Date: 2011-11-17
• [Presentation] 虚血による内側前庭神経核ニューロンの一過性過分極を説明するATP感受性Kチャネル由来の外向きカリウム電流 (2011)
  • Author(s): 紫野正人
  • Organizer: メマイ平衡医学会
  • Place of Presentation: 千葉県 幕張
  • Year and Date: 2011-11-17
• [Presentation] Nobuhiko Furuya Ischemic change of spontaneous firing in medial vestibular neurons. 34th Association for Research in Otolaryngology (ARO) Midwinter meeting (2011)
  • Author(s): Masato Shino, Yukihiro Takayasu
  • Organizer: Baltimore Marriott Waterfront hotel
  • Place of Presentation: Baltimore, USA
  • Year and Date: 2011-03-19
• [Presentation] Ischemic change of spontaneous firing in medial vestibular neurons (2011)
  • Author(s): Shino Masato
  • Organizer: ARO 34th midwinter meeting
  • Place of Presentation: Baltimore, Maryland, USA
  • Year and Date: 2011-02-21
• [Presentation] 内側前庭神経核ニューロンの虚血耐性 (2010)
  • Author(s): 紫野正人
  • Organizer: 第69回 日本めまい平衡医学会
  • Place of Presentation: 京都市 京都国際会議場
  • Year and Date: 2010-11-18
• [Presentation] 内側前庭神経核ニューロンの虚血耐性 (2010)
  • Author(s): 紫野正人, 高安幸弘, 高橋克昌, 宮下元明, 岡宮智史, 古屋信彦
  • Organizer: 第69回日本メマイ平衡医学会総会・学術講演会
  • Place of Presentation: 京都国際会議場(京都)
  • Year and Date: 2010-11-17