Fundamental study on the pathogenesis of swallowing disorders due to aging and disuse syndrome

• Project/Area Number: 22791573
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Otorhinolaryngology
• Research Institution: The University of Tokyo
• Principal Investigator: NITO Takaharu 東京大学, 医学部附属病院, 講師 (60334372)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 嚥下障害 / 嚥下関連筋 / 老化 / 廃用症候群 / 性ホルモン / 嚥下 / 廃用 / ホルモン

Research Abstract

To elucidate the pathogenesis of swallowing disorders due to aging, we investigated theinfluence of sex hormones on the tongue and pharyngeal muscles using various mousemodels and immunohistochemical methods. There was no significant difference in theexpression of sex hormone receptors such as androgen and estrogen between youngand aged mouse groups.

Research Products

• [Journal Article] 老化に伴う嚥下障害の評価と予防 (2011)
  • Author(s): 二藤隆春、山岨達也
  • Journal Title: アンチ・エイジング医学 Volume: 7(2) Pages: 202-207
• [Journal Article] 医療現場からの食介護-耳鼻咽喉科医の立場から-摂食・嚥下障害を考える (2011)
  • Author(s): 二藤隆春
  • Journal Title: 第5集国立健康栄養研究所 Pages: 24-27
• [Presentation] 摂食・嚥下のメカニズムと評価方法 (2013)
  • Author(s): 二藤隆春
  • Organizer: 日野市NST研究会
  • Place of Presentation: 東京
  • Year and Date: 2013-06-13
• [Presentation] Surgicalmanagement of intractable aspiration - survey of the effectiveness of surgery using questionnaire-. (2012)
  • Author(s): Takaharu Nito
  • Organizer: 2nd European Society of swallowing disoreders.
  • Place of Presentation: Barcelona
  • Year and Date: 2012-10-27
• [Presentation] 嚥下障害の基礎から臨床耳鼻咽喉科医が実践する治療の実際 (2011)
  • Author(s): 二藤隆春
  • Organizer: 第56回日本音声言語医学会
  • Place of Presentation: 東京
  • Year and Date: 2011-10-08
• [Presentation] 口腔・咽喉頭の老化とアンチエイジング嚥下のアンチエイジング (2011)
  • Author(s): 二藤隆春
  • Organizer: 第11回日本抗加齢医学会学術講演会
  • Place of Presentation: 京都
  • Year and Date: 2011-05-27
• [Presentation] 医療現場からの食介護-耳鼻咽喉科医の立場から (2010)
  • Author(s): 二藤隆春
  • Organizer: 第5回食介護研究会
  • Place of Presentation: 東京
  • Year and Date: 2010-12-04
• [Presentation] 脳血管障害による嚥下障害への対応-耳鼻咽喉科の立場から (2010)
  • Author(s): 二藤隆春
  • Organizer: 第55回日本音声言語医学会
  • Place of Presentation: 東京
  • Year and Date: 2010-10-15