Comprehensive analysis of mitochondrial DNA mutations in inner ear cells of patients with presbycusis

• Project/Area Number: 22791577
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Otorhinolaryngology
• Research Institution: Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology
• Principal Investigator: KATO Tomofumi 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究員 (80469965)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 耳科学 / 老人性難聴 / ミトコンドリアDNA / 遺伝子解析 / 加齢性難聴 / 活性酸素 / 難聴 / ミトコンドリア / 遺伝子 / 加齢 / 網羅的解析

Research Abstract

We studied the association between the presbycusis and the mutations or the polymorphisms of mitochondrial DNA. Also we compared the patients with suspected hereditary hearing loss with controls. We demonstrated that haplogroup D4b is related to the phenotypic expression of hereditary hearing loss.

Research Products

• [Journal Article] Extended Screening for Major Mitochondrial DNA Point Mutations in Patients with Hereditary Hearing Loss. (2012)
  • Author(s): Kato T, Nishigaki Y, Noguchi Y, et al.
  • Journal Title: J Hum Genet. Volume: 57 Pages: 772-5
  • NAID: 10031145884
• [Journal Article] Mitochondrial DNA Haplogroup associated with Hereditary Hearing Loss in a Japanese Population. (2012)
  • Author(s): Kato T, Fuku N, Noguchi Y, et al.
  • Journal Title: Acta Otolaryngol. Volume: 132 Pages: 1178-82
• [Journal Article] Mitochondrial DNA Haplogroup associated with Hereditary Hearing Loss in a Japanese Population (2012)
  • Author(s): Kato T
  • Journal Title: Acta Otolaryngol Volume: 132 Pages: 1178-1182
  • Peer Reviewed
• [Journal Article] Extended screening for major mitochondrial DNA point mutations in patients with hereditary hearing loss. (2012)
  • Author(s): Kato T, Nishigaki Y, Noguchi Y, Fuku N, Ito T, Mikami E, Kitamura K, Tanaka M.
  • Journal Title: J Hum Genet Volume: 57 Issue: 12 Pages: 772-775
  • DOI: 10.1038/jhg.2012.109
  • Peer Reviewed
• [Presentation] Mitochondrial DNA Haplogroup Analysis Associated with Presbycusis in a Japanese Population (2012)
  • Organizer: The First Asian Otology Meeting & the 3^<rd> East Asian Symposium on Otology
  • Place of Presentation: Nagasaki
  • Year and Date: 2012-06-02
• [Presentation] Mitochondrial Haplogroup Analysis in Patients with Hereditary Hearing Loss (2012)
  • Organizer: The 35^<th> annual midwinter research meeting of the Association for Research in Otolaryngology
  • Place of Presentation: San Diego, USA
• [Presentation] Mitochondrial DNA Haplogroup Analysis Associated with Presbycusis in a Japanese Population (2012)
  • Author(s): Kato T
  • Organizer: The First Asian Otology Meeting & the 3rd East Asian Symposium on Otology
  • Place of Presentation: 長崎市
• [Presentation] Mitochondrial Haplogroup Analysis in Patients with Hereditary Hearing Loss (2012)
  • Author(s): Tomofumi Kato
  • Organizer: The 35^<th> annual midwinter research meeting of the Association for Research in Otolaryngology
  • Place of Presentation: San Diego, United States
• [Presentation] 遺伝性難聴疑い症例のミトコンドリアハプログループ解析 (2011)
  • Organizer: 第21回日本耳科学会総会・学術講演会
  • Place of Presentation: 沖縄市
• [Presentation] 遺伝性難聴疑い症例のミトコンドリアハプログループ解析 (2011)
  • Author(s): 加藤智史
  • Organizer: 第21回日本耳科学会総会・学術講演会
  • Place of Presentation: 沖縄
• [Presentation] Extensive and rapid screening for major mitochondrial DNA point mutations in patients with hereditary hearing loss (2010)
  • Author(s): Kato T
  • Organizer: The 7^<th> Conference of Asian Society for Mitochondrial Research and Medicine
  • Place of Presentation: Fukuoka, Japan
  • Year and Date: 2010-12-16
• [Presentation] Extensive and rapid screening for major mitochondrial DNA point mutations in patients with hereditary hearing loss (2010)
  • Organizer: The 7^<th> Conference of Asian Society for Mitochondrial Reseach and Medicine
  • Place of Presentation: Fukuoka
• [Presentation] Extensive and rapid screening for major mitochondrial DNA point mutations in patients with hereditary hearing loss (2010)
  • Organizer: 2^<nd> East Asian Symposium on Otology
  • Place of Presentation: Taipei, Taiwan
• [Presentation] 遺伝性難聴症例に対する網羅的・迅速検出法を用いた主要ミトコンドリアDNA点変異の解析<第2報> (2010)
  • Organizer: 第20回日本耳科学会総会・学術講演会
  • Place of Presentation: 松山市