Comprehensive analysis of mitochondrial DNA mutations in inner ear cells of patients with presbycusis
Project/Area Number |
22791577
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Otorhinolaryngology
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Research Institution | Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology |
Principal Investigator |
KATO Tomofumi 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究員 (80469965)
|
Project Period (FY) |
2010 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
Keywords | 耳科学 / 老人性難聴 / ミトコンドリアDNA / 遺伝子解析 / 加齢性難聴 / 活性酸素 / 難聴 / ミトコンドリア / 遺伝子 / 加齢 / 網羅的解析 |
Research Abstract |
We studied the association between the presbycusis and the mutations or the polymorphisms of mitochondrial DNA. Also we compared the patients with suspected hereditary hearing loss with controls. We demonstrated that haplogroup D4b is related to the phenotypic expression of hereditary hearing loss.
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Report
(4 results)
Research Products
(14 results)