Research of signaling mechanism in nasopharyngeal cancer

Research Project

Project/Area Number	22791579
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Otorhinolaryngology
Research Institution	Kanazawa University
Principal Investigator	ENDO Kazuhira 金沢大学, 大学病院, 助教 (30547154)
Project Period (FY)	2010 – 2012
Project Status	Completed (Fiscal Year 2012)
Budget Amount *help	¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000) Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords	上咽頭癌 / EBウイルス / LMP1 / SATB1
Research Abstract	A global regulator of chromatin remodelling and gene expression, special AT-rich-binding protein 1 (SATB1) has been implicated in promotion of growth and metastasis of a number of cancers. Here, we demonstrate that the principal oncogene of Epstein-Barr virus (EBV), latent membrane protein 1 (LMP1) upregulates SATB1 RNA and protein expression in human nasopharyngeal cell lines.We show that SATB1 protein levels are elevated in tissue samplesfrom patients with nasopharyngeal carcinoma (NPC). Taken together, our results suggest that SATB1 functions as a prometastatic effector of LMP1 signalling in EBV-positive NPC.

Report

(4 results)