Functional analyses of G691S RET polymorphism in proliferation and invasion of head and neck cancers

• Project/Area Number: 22791580
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Otorhinolaryngology
• Research Institution: University of Fukui
• Principal Investigator: NARITA Norihiko 福井大学, 医学部, 助教 (80345678)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 頭頸部癌 / RET / polymorphism

Research Abstract

It was proven that G691S RET polymorphism, one of the tyrosine receptor kinase could enhance the proliferation and invasion of head and neck cancer through enhanced and extended phosphorylation of ERK and AKT in the downstream of RET. It was shown that the samples of head and neck cancers with neurotropism had high frequency of G691S RET polymorphism. The observation suggested G691S RET polymorphism could enhance growth, invasion, or metastasis of head and neck cancers.

Research Products

• [Journal Article] B type CpG-DNA suppresses poly(I : C)-induced BLyS expression and production in human tonsillar fibroblasts (2011)
  • Author(s): Yamada T, Jiang X, Kubo S, Sakashita M, Narita N, Yamamoto H, Sunaga H, Fujieda S.
  • Journal Title: Clin Immunol Volume: 141(3) Pages: 365-71
  • URL: http://www.ncbi.nlm.nih.gov/pubmed/22015147
• [Journal Article] Prognostic Molecular Biomarkers for Cutaneous Malignant Melanoma (2011)
  • Author(s): Tanaka R, Koyanagi K, Narita N, Kuo C, Hoon DS
  • Journal Title: Journal of Surgical Oncology Volume: 104(4) Pages: 438-46
  • URL: http://www.ncbi.nlm.nih.gov/pubmed/21557225
• [Journal Article] Length of nerve gap defects correlates with incidence of nerve regeneration but not with recovery of taste function in patients with severed chorda tympani nerve (2011)
  • Author(s): Saito T, Narita N, Yamada T, Ogi K, Kanno M, Manabe Y, Ito T.
  • Journal Title: Otol Neurotol Volume: 32(8) Pages: 1352-7
  • URL: http://www.ncbi.nlm.nih.gov/pubmed/21892118
• [Journal Article] Morphology of human fungi form papillae after severing chorda tympani nerve (2011)
  • Author(s): Saito T, Narita N, Yamada T, Manabe Y, Ito T.
  • Journal Title: Ann Otol Rhinol Laryngol Volume: 120(5) Pages: 300-306
  • URL: http://www.ncbi.nlm.nih.gov/pubmed/21675585
• [Journal Article] Light and electron microscopic observation of regenerated fungi form taste buds in patients with recovered taste function after severing chorda tympani nerve (2011)
  • Author(s): Saito T, Ito T, Narita N, Yamada T, Manabe Y.
  • Journal Title: Ann Otol Rhinol Laryngol 120 Volume: 120(11) Pages: 713-21
  • URL: http://www.ncbi.nlm.nih.gov/pubmed/22224312
• [Journal Article] Interleukin-19 down regulates Interleukin-4-induced eotaxin production in human nasal fibroblasts (2011)
  • Author(s): Higashino M, Takabayashi T, Takahashi N, Okamoto M, Narita N, Kojima A, Hyo S, Kawata R, Takenaka H, Fujieda S.
  • Journal Title: Allergology International Volume: 60(4) Pages: 449-57
  • NAID: 130004477105
  • URL: http://www.ncbi.nlm.nih.gov/pubmed/21593579
• [Journal Article] Platelet derived endothelial cell growth factor/thymidine phosphorylase enhanced human IgE production (2011)
  • Author(s): Yamamoto H, Yamada T, Takabayashi T, Sunaga H, Oh M, Narita N, Kojima A, Fujieda S.
  • Journal Title: Allergology International Volume: 60 Pages: 79-85
  • NAID: 10031143302
  • URL: http://www.ncbi.nlm.nih.gov/pubmed/21252618
• [Journal Article] Suppression of histone deacetylase 3(HDAC3) enhances apoptosis induced by paclitaxel in human maxillary cancer cells in vitro and in vivo (2010)
  • Author(s): Narita N, Fujieda S, Kimura Y, Ito Y, Imoto Y, Ogi K, Takahashi N, Tanaka T, Tsuzuki H, Yamada T, Matsumoto H.
  • Journal Title: Biochem Biophys Res Commun Volume: 396 Pages: 310-6
  • URL: http://www.ncbi.nlm.nih.gov/pubmed/20417177
• [Journal Article] B7-h3 ligand expression by primary breast cancer and associated with regional nodal metastasis (2010)
  • Author(s): Arigami T, Narita N, Mizuno R, Nguyen L, Ye X, Chung A, Giuliano AE, Hoon DS.
  • Journal Title: Ann Surg Volume: 252 Pages: 1044-51
  • URL: http://www.ncbi.nlm.nih.gov/pubmed/21107115
• [Journal Article] Development of Sporadic Microsatellite Instability in Colorectal Tumors Involves Hypermethylation at Methylated-In-Tumor Loci in Adenoma (2010)
  • Author(s): de Maat MF, Narita N, Benard A, Yoshimura T, Kuo C, Tollenaar RA, de Miranda NF, Turner RR, van de Velde CJ, Morreau H, Hoon DS.
  • Journal Title: Am J Pathol Volume: 177 Pages: 2347-56
  • URL: http://www.ncbi.nlm.nih.gov/pubmed/20952593
• [Journal Article] Poly(I : C) induces BLyS-expression of airway fibroblasts through phosphatidylinositol 3-kinase (2010)
  • Author(s): Yamada T, Lizhong S, Takahashi N, Kubo S, Narita N, Suzuki D, Takabayashi T, Kimura Y, Fujieda S.
  • Journal Title: Cytokine Volume: 50 Pages: 163-9
  • URL: http://www.ncbi.nlm.nih.gov/pubmed/20089415
• [Journal Article] Aberrant fatty acid-binding protein-7 gene expression in cutaneous malignant melanoma (2010)
  • Author(s): Goto Y, Koyanagi K, Narita N, Kawakami Y, Takata M, Nguyen L, Nguyen T, Ye X, Morton DL, Hoon DS.
  • Journal Title: J Invest Dermatol Volume: 130 Pages: 221-9
  • URL: http://www.ncbi.nlm.nih.gov/pubmed/19587692
• [Journal Article] Suppression of histone deacetylase 3 (HDAC3) enhances apoptosis induced by paclitaxel in human maxillary cancer cells in vitro and in vivo. (2010)
  • Author(s): N Narita
  • Journal Title: Biochem Biophys Res Commun. Volume: 396 Pages: 310-316
  • Peer Reviewed
• [Presentation] A novel molecular target to overcome cisplatin-resistance in human maxillary cancer (2011)
  • Author(s): Norihiko Narita, Yumi Ito, Dai Susuki, Yuichi Kimura, Shigeharu Fujieda
  • Organizer: 11^<th> Japan-Taiwan Conference on Otolaryngology, Head and Neck Surgery
  • Place of Presentation: Kobe
• [Presentation] Shigeharu Fujieda Analysis of molecular targets in chemo-radiation therapy for human head and neck cancer (2011)
  • Author(s): Norihiko Narita, Yumi Ito, Yuichi Kimura, Dai Susuki, Chizuru Sugimoto
  • Organizer: 70^<th> Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: Nagoya
• [Presentation] ヒト舌癌細胞株における放射線耐性に関与する標的分子の解析 (2011)
  • Author(s): 成田憲彦,伊藤有未,木村有一,鈴木弟,杉本千鶴,藤枝重治
  • Organizer: 第35回日本頭頸部癌学会
  • Place of Presentation: 名古屋
• [Presentation] ヒト上顎癌細胞株におけるシスプラチン耐性に関与する新規分子の解析 (2011)
  • Author(s): 成田憲彦,伊藤有未,能美希,扇和弘,木村有一,杉本千鶴,藤枝重治
  • Organizer: 第112回日本耳鼻咽喉科学会総会
  • Place of Presentation: 京都
• [Presentation] Analysis of molecular targets in chemo-radiation therapy for human head and neck cancer (2011)
  • Author(s): Norihiko Narita
  • Organizer: 70^<th> Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: Nagoya
• [Presentation] Fujieda S Analysis of molecular targets to overcome cisplatin-resistance in human maxillary cancer (2010)
  • Author(s): Narita N, Matsumoto H, Yamamoto H, Kimura Y
  • Organizer: 29th International Symposium of Infection and Allergy of the Nose(ISIAN)
  • Place of Presentation: Juneva
• [Presentation] HDAC3抑制はヒト上顎癌細胞株においてパクリタキセルにより誘導されるアポトーシスを増強した (2010)
  • Author(s): 成田憲彦,木村有一,杉本千鶴,藤枝重治
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪
• [Presentation] ヒト上顎癌細胞株におけるシスプラチン耐性に関与する標的分子の解析 (2010)
  • Author(s): 成田憲彦,鈴木弟,木村有一,杉本千鶴,藤枝重治
  • Organizer: 第34回日本頭頸部癌学会
  • Place of Presentation: 東京
• [Presentation] 魚骨異物が原因と考えられる食道壁内膿瘍の1症例 (2010)
  • Author(s): 成田憲彦,加藤幸宣,高林哲司,木村有一,藤枝重治
  • Organizer: 第20回日本頭頸部外科学会総会
  • Place of Presentation: 東京
• [Presentation] Analysis of molecular targets to overcome cisplatin-resistance in human maxillary cancer. (2010)
  • Author(s): N Narita
  • Organizer: 23rd Congress of the European Rhinologic Society (ERS)
  • Place of Presentation: Geneva
• [Presentation] Suppression of histone deacetylase 3 (HDAC3) enhances apoptosis induced by paclitaxel in human maxillary cancer cells (2010)
  • Author(s): 成田憲彦
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪