| Project/Area Number |
22791584
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|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Otorhinolaryngology
|
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| Research Institution | University of Fukui |
|---|
Principal Investigator |
SUSUKI Dai 福井大学, 医学部, 医員 (10444225)
|
|---|
| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
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| Keywords | microRNA / HGF / 頭頸部扁平上皮癌 / EMT / Matriptase |
|---|
| Research Abstract |
Hepatocyte growth factor(HGF) is a multifunctional molecule that acts as mitogen, motogen, and/or morphogen in a variety of cells. But how HGF affects the expression of downstream functional genes have not yet been elucidated in detail. In this study, we found several miRNAs that the expression was altered after HGF stimulation in HNSCC cell line HSC3. We found that miR-200c and miR-27b down-regulated by HGF might play an important role for epithelial-mesenchymal transition mediated by ZEB1/E-cadherin and ECM degradation and HGF auto-activation mediated by ST14/matriptase, respectively. These results sugest altered expression of miRNAs directly regulated by HGF might contribute enhanced progressive and invasive characteristics of HNSCC, by regulating the translation of HGF-induced functional molecules.
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