Role of coagulation factors in the eosinophilic inflammation of upper airways

• Project/Area Number: 22791591
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Otorhinolaryngology
• Research Institution: Shiga University of Medical Science
• Principal Investigator: SHIMIZU Shino 滋賀医科大学, 医学部, 医員 (50505592)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 好酸球性副鼻腔炎 / 鼻茸 / トロンビン / ヘパリン / 組織因子 / 凝固因子 / 杯細胞化生 / 好酸球 / 組織因子経路インヒビター / 粘液産生 / 好酸球性副腔炎 / トロンビン-アンチトリンビン複合体 / 粘液産生亢進 / 鼻茸形成 / VEGF

Research Abstract

We have shown that coagulation factors may be involved in the pathogenesisof excessive mucus secretion and nasal polyposis. Moreover, it was shown that mucus production and infiltration of inflammatory cells are attenuated by nasal administration of anticoagulant heparin in ratmodels of rhinitis.

Research Products

• [Journal Article] The effect of heparin on antigen-induced mucus hypersecretion in the nasal epithelium of sensitized rats (2013)
  • Author(s): Ogawa T, Shimizu S, Shimizu T.
  • Journal Title: Allergol Int Pages: 77-83
  • NAID: 130004477169
  • Peer Reviewed
• [Journal Article] The Effect of Heparin on Antigen-Induced Mucus Hypersecretion in the Nasal Epithelium of Sensitized Rats (2013)
  • Author(s): Takao Ogawa
  • Journal Title: Allergology International Volume: 62 Issue: 1 Pages: 77-83
  • DOI: 10.2332/allergolint.12-OA-0438
  • NAID: 130004477169
  • ISSN: 1323-8930, 1440-1592
  • Peer Reviewed
• [Journal Article] Heparin inhibits mucus hypersecretion in airway epithelial cells (2011)
  • Author(s): Ogawa T, Shimizu S, Tojima I, Kouzaki H, Shimizu T
  • Journal Title: Am J Rhinol Allergy Volume: 25 Issue: 2 Pages: 69-74
  • DOI: 10.2500/ajra.2011.25.3562
  • Peer Reviewed
• [Journal Article] Role of thrombin in chronic rhinosinusitis-associated tissue remodeling. (2011)
  • Author(s): Shimizu S, Gabazza EC, Ogawa T, Tojima I, Hoshi E, Kouzaki H, Shimizu T
  • Journal Title: Am J Rhinol Allergy Volume: 25 Issue: 1 Pages: 7-11
  • DOI: 10.2500/ajra.2011.25.3535
  • Peer Reviewed
• [Journal Article] 上気道炎症に対する新たな局所治療薬としてのヘパリンの可能性 (2011)
  • Author(s): 小河孝夫、清水志乃、戸嶋一郎、神前英明、清水猛史
  • Journal Title: 耳鼻咽喉科免疫アレルギー Volume: 29 Pages: 221-227
  • NAID: 10030647004
  • URL: http://mol.medicalonline.jp/library/archive/search?jo=ch6menek&ye=2011&vo=29&nu=3&st=221
• [Journal Article] Role of thrombin in chronic rhinosinusitis-associated tissue remodeling (2011)
  • Author(s): Shino Shimizu, et.al.
  • Journal Title: American Journal of Rhinology & Allergy Volume: 25-1 Pages: 7-11
  • Peer Reviewed
• [Journal Article] Role of Coagulation System in Inflammatory Responses of the Airways (2010)
  • Author(s): 清水志乃
  • Journal Title: Nihon Bika Gakkai Kaishi (Japanese Journal of Rhinology) Volume: 49 Issue: 1 Pages: 1-7
  • DOI: 10.7248/jjrhi.49.1
  • NAID: 130004546007
  • ISSN: 0910-9153, 1883-7077
• [Presentation] 鼻副鼻腔における Tissue factor と Tissue factor pathway inhibitor (2013)
  • Author(s): 清水志乃、神前英明、清水猛史
  • Organizer: 第31回日本耳鼻咽喉科免疫アレルギー学会
  • Place of Presentation: 岡山
• [Presentation] 鼻副鼻腔におけるTissue factorとTissue factor pathway inhibitor (2013)
  • Author(s): 清水志乃
  • Organizer: 第31回日本耳鼻咽喉科免疫アレルギー学会
  • Place of Presentation: 岡山
• [Presentation] 鼻副鼻腔における組織因子と組織因子経路インヒビター (2012)
  • Author(s): 清水志乃、神前英明、清水猛史
  • Organizer: 第62回日本耳鼻咽喉科免疫アレルギー学会秋季学術大会
  • Place of Presentation: 大阪
• [Presentation] 鼻副鼻腔における組織因子と組織因子経路インヒビター (2012)
  • Author(s): 清水志乃
  • Organizer: 第62回日本アレルギー学会秋季学術大会
  • Place of Presentation: 大阪
• [Presentation] Heparin inhibits mucus hypersecretion in nasal epithelium of the sensitized rats. (2012)
  • Author(s): Takao Ogawa
  • Organizer: 15th Asian Research Symposium in Rinology
  • Place of Presentation: Singapore
• [Presentation] Eosinophil-epithelial cell interaction enhances mucin production and tissue remodeling. (2012)
  • Author(s): Shino Shimizu
  • Organizer: 第14回日韓耳鼻咽喉科頭頸部外科学会
  • Place of Presentation: 京都
• [Presentation] アレルギー性炎症によるラット鼻粘膜上皮の粘液産生と好酸球・好中球浸潤に対するヘパリンの抑制作用 (2011)
  • Author(s): 小河孝夫、清水志乃, その他
  • Organizer: 第61回日本アレルギー学会秋季学術大会
  • Place of Presentation: 東京
  • Year and Date: 2011-11-12
• [Presentation] 凝固系因子と鼻副鼻腔リモデリング (2011)
  • Author(s): 清水志乃
  • Organizer: 第14回滋賀県耳鼻咽喉科オープンセミナー
  • Place of Presentation: 滋賀
  • Year and Date: 2011-01-13
• [Presentation] Role of Coagulation System in Tissue Remodeling of Sinonasal Inflammation (2011)
  • Author(s): Takeshi Shimizu, Shino Shimizu, Takao Ogawa, Ichiro Tojima, Hideaki Kouzaki
  • Organizer: IRS & ISIAN 2011
  • Place of Presentation: 東京
• [Presentation] アレルギー性炎症によるラット鼻粘膜上皮の粘液産生と好酸球・好中球浸潤に対するヘパリンの抑制作用 (2011)
  • Author(s): 小河孝夫、清水志乃、戸嶋一郎、神前英明、清水猛史
  • Organizer: 第29回日本耳鼻咽喉科免疫アレルギー学会
  • Place of Presentation: 大分
• [Presentation] Heparin Inhibits Mucus Hypersecretion in Rat Nasal Epithelium (2011)
  • Author(s): Takao Ogawa, Shino Shimizu, et.al.
  • Organizer: IRS & ISIAN 2011
  • Place of Presentation: 東京
• [Presentation] アレルギー性炎症によるラット鼻粘膜上皮の粘液産生と好酸球・好中球浸潤に対するヘパリンの抑制作用 (2011)
  • Author(s): 小河孝夫、清水志乃, その他
  • Organizer: 第29回日本耳鼻咽喉科免疫アレルギー学会
  • Place of Presentation: 大分全日空ホテルオアシスタワー(大分県)
• [Presentation] In Vivo and in Vitro Effects of Heparin on Mucus Secretion in Airway Epithelial Cells (2010)
  • Author(s): Shino Shimizu, Takao Ogawa, Ichiro Tojima, Takeshi Shimizu
  • Organizer: The 13th Korea Japan Joint Meeting of OtorhinolaryngologyHead and Neck Surgery
  • Place of Presentation: Korea
• [Presentation] In vivo and in vitro effects of heparin on mucus secretion in airway epithelial cells (2010)
  • Author(s): Shino Shimizu, Takao Ogawa, Ichiro Tojima, Takeshi Shimizu
  • Organizer: ERS&ISIAN
  • Place of Presentation: Geneva
• [Presentation] 上気道炎症に対するヘパリンの抗炎症作用の検討 (2010)
  • Author(s): 小河孝夫、清水志乃、戸嶋一郎、柴山将之、瀬野悟史、清水猛史
  • Organizer: 第111回日本耳鼻咽喉科学会
  • Place of Presentation: 仙台
• [Presentation] 気道炎症に対するヘパリンの抗炎症作用について (2010)
  • Author(s): 小河孝夫, 清水志乃, 戸嶋一郎, 柴山将之,瀬野悟史,星 恵理子,清水猛史
  • Organizer: 第28回日本耳鼻咽喉科免疫アレルギー学会
  • Place of Presentation: 福井
• [Presentation] In vivo and in vitro effects of heparin on mucus secretion in airway epithelial cells. (2010)
  • Author(s): Shino Shimizu, et.al.
  • Organizer: ERS&ISIAN 2010
  • Place of Presentation: Switzerland Geneve
• [Presentation] In Vivo and in Vitro Effects of Heparin on Mucus Secretion in Airway Epithelial Cells (2010)
  • Author(s): Shino Shimizu, et.al.
  • Organizer: The 13th Korea Japan Joint Meeting of Otorhinolaryngo logy-Head and Neck Surgery
  • Place of Presentation: Korea Seoul
• [Presentation] Role of Coagulation System in Tissue Remodeling of Sinonasal Inflammation (2010)
  • Author(s): Takeshi Shimizu, Shino Shimizu, et.al.
  • Organizer: The 13th Korea Japan Joint Meeting of Otorhinolaryngo logy-Head and Neck Surgery
  • Place of Presentation: Korea Seoul
• [Presentation] 上気道炎症に対するヘパリンの抗炎症作用の検討 (2010)
  • Author(s): 小河孝夫、清水志乃, その他
  • Organizer: 第111回日本耳鼻咽喉科学会
  • Place of Presentation: 仙台国際センター(宮城県)