| Project/Area Number |
22791594
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
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| Research Collaborator |
SHIMIZU Takeshi 滋賀医科大学, 医学部, 教授 (00206202)
KITA Hirohito 米国メイヨクリ二ック, アレルギー免疫部門, 教授
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | サイトカイン / 上皮細胞 / 好酸球性副鼻腔炎 / アレルギー / 抗原 / 気道上皮細胞 / アレルゲン / プロテアーゼ / IL-33 / IL-25 / TSLP |
|---|
| Research Abstract |
We focused attention on TSLP, IL-25, IL-33 which are the cytokines produced by the respiratory tract and nasal-mucosa epithelial cells and found out that these cytokines are regulated by the allergen proteases in the airway epithelial cells. IL-33 was released from epithelial cells through an ATP receptor. In addition, IL-25 was regulated through the ATP receptor and PAR-2 receptor on the epithelial cells. The expression of TSLP, IL-25, and IL-33 in the epithelial cells of nasal polyp in the patients with eosinophilic chronic sinusitis, were up-regulated. It was presumed that these cytokines lead to development and exacerbation of eosinophilic chronic sinusitis
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