Hedgehog signali ng regulates middle and external ear development

• Project/Area Number: 22791596
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Otorhinolaryngology
• Research Institution: Kyoto University
• Principal Investigator: KADA Shinpei 京都大学, 医学研究科, 医員 (70543263)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 中耳 / 外耳 / 発生 / ヘッジホッグ / Smoothened / Emx2 / ヘッジホッグシグナル / 中耳・外耳発生 / 第一・第二鯉弓

Research Abstract

Hedgehog signaling is reported to play important roles in morphogenesis in the developmental stage of various organs. However, little is known about the roles of hedgehog signaling in the development of middle and external ear. We have developed Emx2(+/Cre); Rosa26SmoM2 transgenic mice, which overexpress hedgehog signaling in a target organ, and found anomaly of the external ear, which suggests that hedgehog signaling plays some role in the development of the external ear.