Regeneration study of olfactory epithelium and olfactory bulb using bone marrow cells

• Project/Area Number: 22791603
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Otorhinolaryngology
• Research Institution: Okayama University
• Principal Investigator: YOSHINOBU Junko 岡山大学, 医学部, 技術専門職員 (80448224)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000); Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 再生医学 / 細胞・組織 / シグナル伝達 / 脳・神経

Research Abstract

This study was conducted to promote regeneration of olfactory organ with the aim to establish the regenerative therapy in rhinology, using bone marrow cells. As a result, valproic acid (antiepileptic drug) promoted transcriptional activation in regeneration of olfactory bulb, and it was suggested that valproic acid had possibility to recover neuronal cell-producing capacity. Also,the use of cytokine is effective for long-term olfaction disorder. However, it was suggested about the differentiation instruction to the neuronal cells of the bone marrow cells that the examination of a new factor was necessary.