Study about the role of aggregations in age related healing loss model from the view of molecular chaperon

• Project/Area Number: 22791606
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Otorhinolaryngology
• Research Institution: Yamaguchi University
• Principal Investigator: MIKURIYA Takefumi 山口大学, 医学部附属病院, 助教 (00467797)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 凝集体 / 老人性難聴 / 内耳保護 / 熱ショック応答 / 熱ショック蛋白質 / 分子シャペロン

Research Abstract

We showed that the relation between formation of aggregation and HSP upregulation and demonstrate the possibility that increase of aggregation may a protective role in spiral ganglion cells.

Research Products

• [Journal Article] Geranylgeranylacetone suppresses noise-induced expression of proinflammatory cytokines in the cochlea (2012)
  • Author(s): Tetsuya Nakamoto, Takefumi Mikuriya, Kazuma Sugahara, Yoshinobu Hirose, Tomoko Hashimoto, Hiroaki Shimogori, Ryosuke Takii, Akira Nakai, Hiroshi Yamashita
  • Journal Title: Auris Nasus Larynx Volume: 39 Pages: 270-274
  • Peer Reviewed
• [Journal Article] モルモット内有毛細胞のシナプス評価法の確立 (2012)
  • Author(s): 金川英寿、菅原一真、豊田英樹、御厨剛史、下郡博明、山下裕司
  • Journal Title: 頭頸部自律神経 Volume: 26 Pages: 81-83
• [Journal Article] Geranylgeranylacetone suppresses noise-induced expression of inflammatory cytokines in the cochlea (2012)
  • Author(s): 中本, 御厨, ら
  • Journal Title: Auris Nasas Larynx Volume: 39 Pages: 270-274
  • Peer Reviewed
• [Journal Article] 熱ショック蛋白質誘導剤(ゲラニルゲラニルアセトン)を用いた老人性難聴モデルマウスの難聴進行の抑制 (2010)
  • Author(s): 御厨剛史
  • Journal Title: 山口医学 Volume: 59 Pages: 153-160
  • NAID: 10030704702
• [Journal Article] 熱ショック蛋白質誘導剤(ゲラニルゲラニルアセトン)を用いた老人性難聴モデルマウスの難聴進行の抑制(解説) (2010)
  • Author(s): 御厨剛史
  • Journal Title: 山口医学 Volume: 59 Pages: 153-160
• [Presentation] Relation between formation of aggregations and upregulation of heart shock protein in animal models (2012)
  • Author(s): Mikuriya
  • Organizer: Midwinter meeting of ARO
  • Place of Presentation: San Diego, USA
  • Year and Date: 2012-02-26
• [Presentation] Relation between formation of aggregations and upregulation of heart shock protein in animal models (2012)
  • Author(s): Takefumi Mikuriya, Kazuma Sugahara, Yoshinobu Hirose, Eijyu Kanagawa, Syuuhei Yoshida, Hiroaki Shimogori, Hiroshi Yamashita
  • Organizer: 35th Annual MidWinter Research Meeting of the Association for Research in Otolaryngology
  • Place of Presentation: San Diego, USA
  • Year and Date: 2012-02-25
• [Presentation] 熱ショック応答と蝸牛内凝集体形成についての関連についての検討 (2011)
  • Author(s): 御厨剛史, 菅原一真, 金川英寿, 津田潤子, 下郡博明, 山下裕司
  • Organizer: 第56回日本聴覚医学会総会・学術講演会
  • Place of Presentation: 福岡アクロス福岡
  • Year and Date: 2011-10-27
• [Presentation] Increase of aggregations after noise injury in guinea pig (2011)
  • Author(s): Takefumi Mikuriya
  • Organizer: ARO 34th MidWinter Meeting
  • Place of Presentation: Baltimore, Maryland, USA
  • Year and Date: 2011-02-20
• [Presentation] Incase of Aggregations after noise injury in guinea pig (2011)
  • Author(s): Takefumi Mikuriya, Kazuma Sugahara, Yoshinobu Hirose, Eijyu Kanagawa, Syuuhei Yoshida, Hiroaki Shimogori, Hiroshi Yamashita
  • Organizer: 34th association for reseach in otolaryngology
  • Place of Presentation: Baltimore, USA
  • Year and Date: 2011-02-19
• [Presentation] 音響ストレス下での蝸牛内凝集体形成についての検討 (2010)
  • Author(s): 御厨剛史, 菅原一真, 金川英寿, 橋本誠, 下郡博明, 山下裕司
  • Organizer: 第55回日本聴覚医学会総会・学術講演会
  • Place of Presentation: 奈良奈良県新公会堂
  • Year and Date: 2010-11-11
• [Presentation] 音響ストレス下での蝸牛内凝集体形成についての検討 (2010)
  • Author(s): 御厨剛史
  • Organizer: 第55回聴覚医学会
  • Place of Presentation: 奈良県奈良市新公会堂
  • Year and Date: 2010-11-11
• [Presentation] 熱ショック蛋白質誘導剤(ゲラニルゲラニルアセトン)を用いた老人性難聴モデルマウスの難聴進行の抑制 (2010)
  • Author(s): 御厨剛史
  • Organizer: 第114回山口大学医学会学術講演会
  • Place of Presentation: 宇部山口大学
  • Year and Date: 2010-07-17
• [Presentation] 進行性難聴モデルの蝸牛内凝集体についての検討 (2010)
  • Author(s): 御厨剛史, 菅原一真, 広瀬敬信, 山下裕司
  • Organizer: 第4回聴覚アンチエイジング研究会
  • Place of Presentation: 東京慶應義塾大学病院
  • Year and Date: 2010-07-02
• [Presentation] 進行性難聴モデルの蝸牛内凝集体についての研究 (2010)
  • Author(s): 御厨剛史
  • Organizer: 第4回聴覚アンチエイジング研究会
  • Place of Presentation: 東京都慶應義塾大学病院
  • Year and Date: 2010-07-02
• [Presentation] 内耳熱ショック蛋白質と凝集体についての検討 (2010)
  • Author(s): 御厨剛史, 菅原一真, 下郡博明, 山下裕司
  • Organizer: 第111回日本耳鼻咽喉科学会総会・学術講演会
  • Place of Presentation: 仙台国際センター
  • Year and Date: 2010-05-20