Analysis of the development of spiral ganglion cells utilizingPC3-GFP knock-in mice

• Project/Area Number: 22791610
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Otorhinolaryngology
• Research Institution: Kumamoto University
• Principal Investigator: YAMADA Takao 熊本大学, 医学部附属病院, 医員 (90573593)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2010: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 耳科学 / 遺伝子 / ラセン神経節 / 分化

Research Abstract

In order to elucidate the development mechanism of cochlear spiralganglion cells, we investigated the PC3 gene. PC3 gene was expressed at the spiral ganglioncells of heterozygous PC3-GFP knock-in mice. Spiral ganglion cells were decreased inhomozygous PC3-GFP knock-in mice. The results indicate that PC3 gene is involved in thedevelopment of spiral ganglion cells.

Research Products

• [Presentation] Tis21 is involved in development of spiralganglion cells (2013)
  • Author(s): 山田 卓生、三輪 徹、伊勢 桃子、蓑田涼生、湯本英二
  • Organizer: Tis21 is involved in development of spiralganglion cells
  • Place of Presentation: Baltimore Marriott WaterfrontHotel(アメリカ合衆国 ボルチモア)
  • Year and Date: 2013-02-19
• [Presentation] Tis21 is involved in development of spiral ganglion cells (2013)
  • Author(s): 山田 卓生
  • Organizer: Association for Research in Otolaryngology
  • Place of Presentation: アメリカ合衆国 ボルチモア
• [Presentation] Tis21 遺伝子改変マウスの蝸牛ラセン神経節細胞における Tis21 の発現 (2012)
  • Author(s): 山田 卓生、三輪 徹、伊勢 桃子、蓑田涼生、湯本 英二
  • Organizer: 日本耳科学会
  • Place of Presentation: 名古屋国際会議場(名古屋)
  • Year and Date: 2012-10-05