Investigation to elucidate the mechanism of the onset of acute lung injury by the EGFR inhibitors, and the development of that suppression method
Project/Area Number |
22791619
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Otorhinolaryngology
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Research Institution | Yokohama City University |
Principal Investigator |
ISHIGURO Yukari 横浜市立大学, 医学研究科, 特任助教 (00423830)
|
Project Period (FY) |
2010 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
|
Keywords | EGFR阻害剤 / 急性肺障害 |
Research Abstract |
Acute interstitial pneumonia is one of serious side effects of epidermal growth factor receptor(EGFR)-tyrosine kinase inhibitor(TKI), although that cause is still unknown. In the present study, we investigated that cancer cells treated with EGFR blocker induce fibrosis of human lung fibroblast. These data suggested that acute interstitial pneumonia was induced some unknown factors from cancer cells treated with EGFR blocker.
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Report
(3 results)
Research Products
(6 results)
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[Journal Article] Antitumor effects of lapatinib(GW572016), a dual inhibitor of EGFR and HER-2, in combination with cisplatin or paclitaxel on head and neck squamous cell carcinoma2011
Author(s)
Kondo N, Tsukuda M, Ishiguro Y, Kimura M, Fujita K, Sakakibara A, Takahashi H, Toth G, Matsuda H.
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Journal Title
Oncol Rep
Volume: 23(4)
Pages: 957-63
Related Report
Peer Reviewed
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[Journal Article] Antitumor effects of lapatinib (GW572016), a dual inhibitor of EGFR and HER-2, in combination with cisplatin or paclitaxel on head and neck squamous cell carcinoma.2010
Author(s)
Kondo N, Tsukuda M, Ishiguro Y, Kimura M, Fujita K, Sakakibara A, Takahashi H, Toth G, Matsuda H
-
Journal Title
Oncol Rep.
Volume: 23(4)
Pages: 957-63
Related Report
Peer Reviewed
-
-