Investigation to elucidate the mechanism of the onset of acute lung injury by the EGFR inhibitors, and the development of that suppression method

• Project/Area Number: 22791619
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Otorhinolaryngology
• Research Institution: Yokohama City University
• Principal Investigator: ISHIGURO Yukari 横浜市立大学, 医学研究科, 特任助教 (00423830)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2010: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: EGFR阻害剤 / 急性肺障害

Research Abstract

Acute interstitial pneumonia is one of serious side effects of epidermal growth factor receptor(EGFR)-tyrosine kinase inhibitor(TKI), although that cause is still unknown. In the present study, we investigated that cancer cells treated with EGFR blocker induce fibrosis of human lung fibroblast. These data suggested that acute interstitial pneumonia was induced some unknown factors from cancer cells treated with EGFR blocker.

Research Products

• [Journal Article] Examination of the optimal condition on the in vitro sensitivity to telomelysin in head and neck cancer cell lines (2011)
  • Author(s): Sakakibara A, Tsukuda M, Kondo N, Ishiguro Y, Kimura M, Fujita K, Takahashi H, Matsuda H.
  • Journal Title: Auris Nasus Larynx Volume: 38(5) Pages: 589-99
  • Peer Reviewed
• [Journal Article] Antitumor effects of lapatinib(GW572016), a dual inhibitor of EGFR and HER-2, in combination with cisplatin or paclitaxel on head and neck squamous cell carcinoma (2011)
  • Author(s): Kondo N, Tsukuda M, Ishiguro Y, Kimura M, Fujita K, Sakakibara A, Takahashi H, Toth G, Matsuda H.
  • Journal Title: Oncol Rep Volume: 23(4) Pages: 957-63
  • Peer Reviewed
• [Journal Article] Examination of the optimal condition on the in vitro sensitivity to telomelysin in head and neck cancer cell lines. (2011)
  • Author(s): Sakakibara A, Tsukuda M, Kondo N, Ishiguro Y, Kimura M, Fujita K, Takahashi H, Matsuda H
  • Journal Title: Auris Nasus Larynx Volume: 38(5) Pages: 589-99
  • Peer Reviewed
• [Journal Article] Antitumor effects of lapatinib (GW572016), a dual inhibitor of EGFR and HER-2, in combination with cisplatin or paclitaxel on head and neck squamous cell carcinoma. (2010)
  • Author(s): Kondo N, Tsukuda M, Ishiguro Y, Kimura M, Fujita K, Sakakibara A, Takahashi H, Toth G, Matsuda H
  • Journal Title: Oncol Rep. Volume: 23(4) Pages: 957-63
  • Peer Reviewed
• [Presentation] Cancer cells treated with EGFR blocker induce fibrosis of normal human fibroblast cells (2010)
  • Author(s): 石黒由香利, 石黒斉, 佃守
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪国際会議場(大阪)
  • Year and Date: 2010-09-24
• [Presentation] Cancer cells treated with EGFR blocker induce fibrosis of normal human fibroblast cells. (2010)
  • Author(s): 石黒由香利
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2010-09-24