Plasticity of the auditory system

• Project/Area Number: 22791627
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Otorhinolaryngology
• Research Institution: 独立行政法人国立病院機構東京医療センター(臨床研究センター) (2011); Keio University (2010)
• Principal Investigator: MINAMI Hujiro 独立行政法人国立病院機構東京医療センター(臨床研究センター), 聴覚平衡覚研究部, 部員 (00399544)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 聴覚障害 / 聴覚伝導路 / 可塑性 / 経頭蓋磁気刺激 / 耳鳴

Research Abstract

I planned clinical and basic research to investigate the plasticity of auditory system with repetitive transcranial magnetic stimulation(rTMS). Sixteen patients with chronic tinnitus underwent rTMS to the left auditory cortex, and a significant reduction in the tinnitus loudness and annoyance occurred immediately after rTMS. In animal model, rTMS induces the immediate early genes(IEGs) in the auditory cortex.

Research Products

• [Journal Article] Comorbidity of GJB2 and WFS1 mutations in one family (2012)
  • Author(s): Minami SB, Masuda S, Usui S, Mutai H, Matsunaga T
  • Journal Title: Gene
  • Peer Reviewed
• [Journal Article] Repetitive transcranial magnetic stimulation(rTMS) for treatment of chronic tinnitus (2011)
  • Author(s): Minami SB, Shinden S, Okamoto Y, Watada Y, Watabe T, Oishi N, Kanzaki S, Saito H, Inoue Y, Ogawa K
  • Journal Title: Auris Nasus Larynx Volume: 38(3) Pages: 301-306
  • Peer Reviewed
• [Journal Article] Repetitive transcranial magnetic stimulation (rTMS) for treatment of chronic tinnitus (2011)
  • Author(s): Minami SB, Shinden S, Okamoto Y, Watada Y, Watabe T, Oishi N, Kanzaki S, Saito H, Inoue Y, Ogawa K
  • Journal Title: Auris Nasus Larynx Volume: 38(3) Issue: 3 Pages: 301-306
  • DOI: 10.1016/j.anl.2010.09.007
  • Peer Reviewed
• [Journal Article] ストレスと突発性難聴 (2010)
  • Author(s): 神崎晶,増田正次,南修司郎
  • Journal Title: ENTONI Volume: 121 Pages: 13-19
• [Journal Article] Repetitive transcranial magnetic stimulation (rTMS) for treatment of chronic tinnitus. (2010)
  • Author(s): Minami S, Shinden S, Okamoto Y, Watada Y, Watabe T, Oishi N, Kanzaki S, Saito H, Inoue Y, Ogawa K.
  • Journal Title: Auris Nasus Larynx Volume: (Epub ahead of print)
  • Peer Reviewed
• [Presentation] 腸管出血性大腸菌による溶血性尿毒症症候群の治療後に重度難聴と診断された小児の2症例 (2011)
  • Author(s): 南修司郎
  • Organizer: 第21回日本耳科学会学術講演会
  • Place of Presentation: 沖縄
  • Year and Date: 2011-11-25
• [Presentation] フェキソフェナジンを用いた外耳道湿疹の治療について (2011)
  • Author(s): 南修司郎
  • Organizer: 八重山地区病診連携セミナー
  • Place of Presentation: 沖縄石垣
  • Year and Date: 2011-06-22
• [Presentation] WFS1遺伝子変異とGJB2遺伝子変異を併せ持った遺伝性感音難聴の1家系 (2011)
  • Author(s): 南修司郎
  • Organizer: 第112回日本耳鼻咽喉科学会学術講演会
  • Place of Presentation: 京都府京都市
  • Year and Date: 2011-05-21
• [Presentation] Cases of Profound Hearing loss secondary to Enterohemorrhagic Escherichia coli infection in two children (2011)
  • Author(s): Shujiro Minami
  • Organizer: The 8th Asia Pacific Symposium on Cochlear Implant and Related Sciences
  • Place of Presentation: Daegu, Korea
• [Presentation] Repetitive Transcranial Magnetic Stimulation(rTMS) for Treatment of Chronic Tinnitus (2010)
  • Author(s): Shujiro Minami
  • Organizer: Sixth International Symposium on Meniere's Disease and Inner Ear Disorders
  • Place of Presentation: 京都府京都市
  • Year and Date: 2010-11-14
• [Presentation] Repetitive Transcranial Magnetic Stimulation (rTMS) for Treatment of Chronic Tinnitus (2010)
  • Author(s): 南修司郎
  • Organizer: Sixth International Symposium on Meniere's Disease and Inner Ear Disorders
  • Place of Presentation: 京都府京都市
  • Year and Date: 2010-11-14
• [Presentation] 反復経頭蓋磁気刺激(rTMS)による聴覚伝導路 (2010)
  • Author(s): 南修司郎
  • Organizer: Immediate early gene(c-fos)発現の検討日本耳科学会
  • Place of Presentation: 愛媛県松山市
  • Year and Date: 2010-10-09
• [Presentation] 反復経頭蓋磁気刺激(rTMS)による聴覚伝導路Immediate early gene(c-fos)発現の検討 (2010)
  • Author(s): 南修司郎
  • Organizer: 日本耳科学会
  • Place of Presentation: 愛媛県松山市
  • Year and Date: 2010-10-09
• [Presentation] Cancer of temporal bone : reported on 30 patients (2010)
  • Author(s): Shujiro Minami
  • Organizer: JOINT MEETING-IVConsensus in auditory implants & VEAONO INSTRUCTIONAL WORKSHOP
  • Place of Presentation: Parma, Italy
  • Year and Date: 2010-06-16
• [Presentation] Cancer of temporal bone : reported on 30 patients (2010)
  • Author(s): 南修司郎
  • Organizer: OINT MEETING-IV Consensus in auditory implants & V EAONO INSTRUCTIONAL WORKSHOP
  • Place of Presentation: Parma, Italy
  • Year and Date: 2010-06-16