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Research of miRNA function in inner ear disease and new diagnostic biomarker

Research Project

Project/Area Number 22791636
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Otorhinolaryngology
Research InstitutionNippon Medical School

Principal Investigator

SEKINE Kuwon  日本医科大学, 医学部, 助教 (20566377)

Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords内耳 / miRNA / マイクロアレイ / 高齢者 / ラット
Research Abstract

miRNAs are small non-coding RNAs. They are involved in diverse physiological, developmental, and pathological processes by regulating the expression of target messenger RNAs (mRNAs). In the current review, they discuss the developments in miRNAs research with a focus on the potential role of miRNAs in inner ear development, genetic hearing loss. In this study we examined miRNAs expression in plural geriatric human inner ear. In this research we found that these miRNAs that have a important roles in inner ear, are still expressed in old age, and oldest olds. This result shows that these miRNAs have important roles not only in development but also in inner ear maintenance of homeostasis.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (8 results)

All 2012 2011 2010 Other

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (3 results)

  • [Journal Article] Cochlin expression in the rat perilymph during postnatal development2012

    • Author(s)
      Shiiba K, Shindo S, Ikezono T, Sekine K, Matsumura T, Sekiguchi S, Yagi T, Okubo K.
    • Journal Title

      Acta Otolaryngol

      Volume: 132巻 Issue: 11 Pages: 1134-1139

    • DOI

      10.3109/00016489.2012.687456

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cochlin-tomoprotein (CTP) detection test identifies traumatic perilymphatic fistula due to penetrating middle ear injury2011

    • Author(s)
      Ikezono T, et al
    • Journal Title

      Acta Otolaryngol

      Volume: 131(9) Issue: 9 Pages: 937-44

    • DOI

      10.3109/00016489.2011.575795

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular cloning of the Cochgene of guinea pig inner ear and its expression analysis in cultured fibrocytes of the spiral ligament.2010

    • Author(s)
      Li L, Ikezono T, Sekine K, Shindo S, Matsumura T, Pawankar R, Ichimiya I, Yagi T.
    • Journal Title

      Acta Otolaryngol

      Volume: 130巻 Issue: 8 Pages: 868-880

    • DOI

      10.3109/00016480903493766

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression of cochlin mRNA splice variants in the inner ear.2010

    • Author(s)
      Sekine K, Ikezono T, Matsumura T, Shindo S, Watanabe A, Li L, Pawankar R, Nishino T, Yagi T.
    • Journal Title

      Audiol Neurootol

      Volume: 15巻 Issue: 2 Pages: 88-96

    • DOI

      10.1159/000231634

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cochlin expression in the rat perilymph during postnatal development

    • Author(s)
      Shiiba K, Shindo S, Ikezono T, Sekine K, Matsumura T, Sekiguchi S, Yagi T, Okubo K
    • Journal Title

      Acta Otolaryngol

      Volume: (in press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] 高齢者剖検例の内耳におけるmicroRNAの発現2011

    • Organizer
      日本耳科学会
    • Place of Presentation
      沖縄コンベンションセンター
    • Year and Date
      2011-11-24
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Presentation] 高齢者内耳microRNAの発現2010

    • Organizer
      日本耳科学会
    • Place of Presentation
      松山市道後ひめぎんホール
    • Year and Date
      2010-10-08
    • Related Report
      2012 Final Research Report
  • [Presentation] 高齢者内耳microRNAの発現2010

    • Author(s)
      関根久遠
    • Organizer
      日本耳科学会
    • Place of Presentation
      松山市道後ひめぎんホール(愛媛県)
    • Year and Date
      2010-10-08
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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