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Effect of menthol on patients with rhinitis and rhinosinus it is

Research Project

Project/Area Number 22791638
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Otorhinolaryngology
Research InstitutionHyogo Medical University

Principal Investigator

TSUZUKI Kenzo  兵庫医科大学, 医学部, 講師 (50441308)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywordsアレルギー性鼻炎 / 慢性副鼻腔炎 / 嗅覚障害 / 鼻腔内ポリープ / 内視鏡下鼻副鼻腔手術 / 下鼻甲介手術 / メントール / シート式嗅覚検査 / 鼻腔通気度 / カプサイシン
Research Abstract

Patients with rhinitis and rhinosinusitis were analyzed in this study. Olfactory function in the patients was examined using self-administered odor questionnaire(SAOQ), alternative open essence test(OE) recently developed in Japan, T & T olfactometer and intravenous olfaction test. Most patients who underwent endoscopic sinus surgery(ESS) had severe olfactory disorders. We reported a clinical availability of the SAOQ. Menthol was identified in more than half of them even on the preoperative OE test. The mean OE scores, T & T recognition thresholds improved after ESS. Possibility of action of the ligand of menthol via not only somatosensory but also olfactory nerves was suggested.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (41 results)

All 2012 2011 2010

All Journal Article (12 results) (of which Peer Reviewed: 6 results) Presentation (29 results)

  • [Journal Article] 嗅覚障害、耳喉頭頸2012

    • Author(s)
      都築建三、阪上雅史
    • Volume
      84
    • Pages
      129-133
    • Related Report
      2011 Final Research Report
  • [Journal Article] 重篤な鼻出血から診断されたアグレッシブNK細胞白血病例2012

    • Author(s)
      岡崎健、都築建三、岡秀樹、澤田暁宏、岡田昌也、竹林宏記、佐伯暢生、三代康雄、阪上雅史.
    • Journal Title

      耳鼻臨床

      Volume: 105 Pages: 15-20

    • NAID

      10030176037

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clinical availability of aself-administered odor questionnairefor patients with olfactorydisorders2011

    • Author(s)
      Takebayashi H, Tsuzuki K, Oka H, Fukazawa K, Daimon T, Sakagami M.
    • Journal Title

      Auris Nasus Larynx

      Volume: 38 Pages: 65-72

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Utility of real-time diagnosis using contact endoscopy for oral and lingual diseases2011

    • Author(s)
      Saeki N, Tsuzuki K, Negoro A, Nin T, Sagawa K, Uwa N, Mohri T, Terada T, Nishigami T, Sakagami M.
    • Journal Title

      Auris Nasus Larynx

      Volume: 38 Pages: 233-239

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 副鼻腔嚢胞に対する内視鏡下鼻内手術の適応と限界2011

    • Author(s)
      都築建三
    • Journal Title

      JOHNS

      Volume: 27 Pages: 891-895

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Journal Article] 前篩骨洞嚢胞開放後に眼神経領域の帯状疱疹を生じた1症例2011

    • Author(s)
      都築建三、竹林宏記、岡秀樹、池畑美樹、阪上雅史
    • Journal Title

      日本耳鼻咽喉科感染症研究会会誌

      Volume: 29 Pages: 105-109

    • Related Report
      2011 Final Research Report
  • [Journal Article] Clinical availability of a self-administered odor questionnaire for patients with olfactory disorders.2011

    • Author(s)
      Takebayashi H, Tsuzuki K, Oka H, Fukazawa K, Daimon T, Sakagami M
    • Journal Title

      Auris Nasus Larynx

      Volume: 38 Pages: 65-72

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Utility of real-time diagnosis using contact endoscopy for oral and lingual diseases.2011

    • Author(s)
      Saeki N, Tsuzuki K, Negoro A, Nin T, Sagawa K, Uwa N, Mohri T, Terada T, Nishigami T, Sakagami M.
    • Journal Title

      Auris Nasus Larynx.

      Volume: 38 Pages: 233-9

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 乾酪用物質を伴う副鼻腔炎の手術例の検討2010

    • Author(s)
      松原弘、都築建三、竹林宏記、岡秀樹、深澤啓二郎、阪上雅史
    • Journal Title

      耳鼻臨床

      Volume: 103 Pages: 643-649

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 慢性副鼻腔炎による嗅覚障害と鼻内視鏡手術2010

    • Author(s)
      都築建三、阪上雅史
    • Journal Title

      MBT ENT

      Volume: 117 Pages: 58-64

    • Related Report
      2011 Final Research Report
  • [Journal Article] 嗅裂部針状鏡検査、嗅粘膜生検2010

    • Author(s)
      都築建三、阪上雅史
    • Journal Title

      JOHNS

      Volume: 26 Pages: 1128-1132

    • Related Report
      2011 Final Research Report
  • [Journal Article] 鼻閉に対する下鼻甲介外来手術の術後成績2010

    • Author(s)
      都築建三、竹林宏記、岡秀樹、阪上雅史
    • Journal Title

      耳鼻免疫アレルギー

      Volume: 28(2) Pages: 131-132

    • Related Report
      2011 Final Research Report
  • [Presentation] Clinical study of Wegener's granulomatosis in the head and neck region2012

    • Author(s)
      Tsuzuki K, Oka H, Kojima Y, Takebayashi H, Sakagami M.
    • Organizer
      The Asia Pacific Meeting of Vasculitis and ANCA Workshop
    • Place of Presentation
      Tokyo
    • Year and Date
      2012-03-30
    • Related Report
      2011 Final Research Report
  • [Presentation] Clinical study of Wegener's granulomatosis in the head and neck region2012

    • Author(s)
      Tsuzuki K, Oka H, Kojima Y, Takebayashi H, Sakagami M
    • Organizer
      The Asia Pacific Meeting of Vasculitis and ANCA Workshop2012 (AP-VAS 2012)
    • Place of Presentation
      Tokyo
    • Year and Date
      2012-03-30
    • Related Report
      2011 Annual Research Report
  • [Presentation] 外切開を要した良性副鼻腔疾患の手術症例2012

    • Author(s)
      岡秀樹、都築建三、児島雄介、竹林宏記、阪上雅史.
    • Organizer
      第22回日本頭頸部外科学会ならびに学術講演会
    • Place of Presentation
      福島市
    • Related Report
      2011 Final Research Report
  • [Presentation] Olfactory changes after endoscopic sinus surgery in patients with eosinophilic chronic rhinosinusitis2011

    • Author(s)
      Oka H, Tsuzuki K, Daimon T, Kojima Y, Takebayashi H, Sakagami M.
    • Organizer
      11^<th> Japan-Taiwan Conference on Otolaryngology-Head and Neck Surgery
    • Place of Presentation
      Kobe
    • Year and Date
      2011-12-08
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 副鼻腔炎のESS術後の鼻内所見の検討2011

    • Author(s)
      都築建三、岡秀樹、竹林宏記、児島雄介、阪上雅史
    • Organizer
      第50回日本鼻科学会
    • Place of Presentation
      岡山市
    • Year and Date
      2011-12-03
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 味覚・嗅覚教育講演-嗅覚の病態と診断2011

    • Author(s)
      都築建三
    • Organizer
      第50回中部医学検査学
    • Place of Presentation
      名古屋市
    • Year and Date
      2011-10-23
    • Related Report
      2011 Final Research Report
  • [Presentation] 味覚・嗅覚教育講演.嗅覚の病態と診断2011

    • Author(s)
      都築建三
    • Organizer
      第50回中部医学検査学会
    • Place of Presentation
      名古屋市(招待講演)
    • Year and Date
      2011-10-23
    • Related Report
      2011 Annual Research Report
  • [Presentation] Clinical availability of a Self-Administered Odor Questionnaire(SAOQ) for evaluating olfactionfunction test2011

    • Author(s)
      Tsuzuki K.
    • Organizer
      14th International Rhinologic Society & 30th International Symposium on Infection & Allergy of the Nose(IRS-ISIAN)
    • Place of Presentation
      Tokyo
    • Year and Date
      2011-09-21
    • Related Report
      2011 Final Research Report
  • [Presentation] Clinical availability of a Self-Administered Odor Questionnaire (SAOQ) for evaluating olfaction. Symposium. Evolution of olfaction function test2011

    • Author(s)
      Tsuzuki K
    • Organizer
      14th International Rhinologic Society & 30th International Symposium on Infection & Allergy of the Nose (IRS-ISIAN)
    • Place of Presentation
      Tokyo(招待講演)
    • Year and Date
      2011-09-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] 最近5年における片側性副鼻腔炎に対する手術症例の検討2011

    • Author(s)
      児島雄介、都築建三、岡秀樹、竹林宏記、阪上雅史
    • Organizer
      第41回日本耳鼻咽喉科感染症研究会
    • Place of Presentation
      東京都
    • Year and Date
      2011-09-03
    • Related Report
      2011 Final Research Report
  • [Presentation] 多量鼻出血から診断されたアグレッシブNK細胞白血病の症例2011

    • Author(s)
      都築建三、岡秀樹、岡崎健、竹林宏記、阪上雅史
    • Organizer
      第73回耳鼻咽喉科臨床学会
    • Place of Presentation
      松本市
    • Year and Date
      2011-06-24
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 慢性副鼻腔炎に対する内視鏡手術の術後評価2011

    • Author(s)
      都築建三、竹林宏記、岡秀樹、阪上雅史
    • Organizer
      第112回日本耳鼻咽喉科学会総会・学術講演会
    • Place of Presentation
      京都市
    • Year and Date
      2011-05-21
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 気管支喘息を合併した慢性副鼻腔炎手術症例の検討2011

    • Author(s)
      都築建三、竹林宏記、岡秀樹、阪上雅史
    • Organizer
      第29回日本耳鼻咽喉科免疫アレルギー学会
    • Place of Presentation
      大分市
    • Year and Date
      2011-02-11
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] 鼻中隔矯正術および下鼻甲介手術を併用した症例の術後成績2011

    • Author(s)
      児島雄介、都築建三、岡秀樹、竹林宏記、阪上雅史.
    • Organizer
      第30回日本耳鼻咽喉科免疫アレルギー学会
    • Place of Presentation
      大津市
    • Related Report
      2011 Final Research Report
  • [Presentation] 気管支喘息を合併した慢性副鼻腔炎の検討2011

    • Author(s)
      岡秀樹、都築建三、児島雄介、阪上雅史.
    • Organizer
      第30回日本耳鼻咽喉科免疫アレルギー学会
    • Place of Presentation
      大津市
    • Related Report
      2011 Final Research Report
  • [Presentation] 当科における嗅覚障害症例の検討2011

    • Author(s)
      都築建三、岡秀樹、児島雄介、竹林宏記、深澤啓二郎、阪上雅史
    • Organizer
      日本味と匂学会第45回大会
    • Place of Presentation
      金沢市
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 慢性副鼻腔炎による嗅覚障害に対する副鼻腔内視鏡手術の治療成績2011

    • Author(s)
      三輪高喜、小林正佳、近藤健二、都築建三、小河孝夫
    • Organizer
      日本味と匂学会第45回大会
    • Place of Presentation
      金沢市
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Clinical study of patients presenting with epistaxis2011

    • Author(s)
      Takebayashi H, Tsuzuki K, Oka H, Sakagami M, Fukazawa K, Yukitatsu Y.
    • Organizer
      14th International Rhinologic Society & 30th International Symposium on Infection & Allergy of the Nose(IRS-ISIAN)
    • Place of Presentation
      Tokyo
    • Related Report
      2011 Final Research Report
  • [Presentation] Clinical features of 1665 patients with olfactory disorders2011

    • Author(s)
      Oka H, Tsuzuki K, Takebayashi H, Sakagami M, Fukazawa K.
    • Organizer
      14th International Rhinologic Society & 30th International Symposium on Infection & Allergy of the Nose(IRS-ISIAN)
    • Place of Presentation
      Tokyo
    • Related Report
      2011 Final Research Report
  • [Presentation] Clinical study of 1, 515 patients with epistaxis over the last 6 years2011

    • Author(s)
      Yukitatsu Y, Tsuzuki K, Takebayashi H, Oka H, Sakagami M.
    • Organizer
      American Academy of Otolaryngology-Head and Neck Surgery Foundation(AAO-HNSF) Annual Meeting & OTO EXPO
    • Place of Presentation
      San Francisco, CA
    • Related Report
      2011 Final Research Report
  • [Presentation] Clinical features of 1665 patients with olfactory disorders2011

    • Author(s)
      Oka H, Tsuzuki K, Takebayashi H, Sakagami M, Fukazawa K
    • Organizer
      14th International Rhinologic Society & 30th International Symposium on Infection & Allergy of the Nose (IRS-ISIAN)
    • Place of Presentation
      Tokyo
    • Related Report
      2011 Annual Research Report
  • [Presentation] Clinical study of 1515 patients with epistaxis over the last 6 years2011

    • Author(s)
      Yukitatsu Y, Tsuzuki K, Takebayashi H, Oka H, Sakagami M
    • Organizer
      American Academy of Otolaryngology-Head and Neck Surgery Foundation (AAO-HNSF) Annual Meeting & OTO EXPO
    • Place of Presentation
      San Francisco, CA, US
    • Related Report
      2011 Annual Research Report
  • [Presentation] 前篩骨洞嚢胞開放術後に眼神経領域の帯状疱疹を生じた1症例2010

    • Author(s)
      都築建三、竹林宏記、岡秀樹、阪上雅史
    • Organizer
      第40回日本耳鼻咽喉科感染症研究会
    • Place of Presentation
      名古屋市
    • Year and Date
      2010-09-04
    • Related Report
      2011 Final Research Report
  • [Presentation] 慢性副鼻腔炎のESS症例における術前画像と術後鼻内の比較検討2010

    • Author(s)
      都築建三、竹林宏記、岡秀樹、阪上雅史
    • Organizer
      第49回日本鼻科学会
    • Place of Presentation
      札幌市
    • Year and Date
      2010-08-27
    • Related Report
      2011 Final Research Report
  • [Presentation] Results of endoscopic sinus surgery for pediatric sinusitis2010

    • Author(s)
      Takebayashi H, Tsuzuki K, Oka H, Sakagami M.
    • Organizer
      24th Congress of the European Rhinologic Society & 29th International Symposium of Infection & Allergy of the Nose(IRS-ISIAN)
    • Place of Presentation
      Geneva
    • Year and Date
      2010-06-23
    • Related Report
      2011 Final Research Report
  • [Presentation] Results of endoscopic sinus surgery for pediatric sinusitis.2010

    • Author(s)
      Takebayashi H, Tsuzuki K, Oka H, Sakagami M.
    • Organizer
      24th Congress of the European Rhinologic Society & 29^<th> International Symposium of Infection & Allergy of the Nose (ERS-ISIAN)
    • Place of Presentation
      Geneva
    • Year and Date
      2010-06-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] Effect of sinus surgery on olfactory disorder due to chronic sinusitis2010

    • Author(s)
      Tsuzuki K, Takebayashi H, Oka H, Sakagami M.
    • Organizer
      24th Congress of the European Rhinologic Society & 29th International Symposium of Infection & Allergy of the Nose
    • Place of Presentation
      Geneva
    • Year and Date
      2010-06-22
    • Related Report
      2011 Final Research Report
  • [Presentation] Effect of sinus surgery on olfactory disorder due to chronic sinusitis.2010

    • Author(s)
      Tsuzuki K, Takebayashi H, Oka H, Sakagami M.
    • Organizer
      24th Congress of the European Rhinologic Society & 29^<th> International Symposium of Infection & Allergy of the Nose (ERS-ISIAN)
    • Place of Presentation
      Geneva
    • Year and Date
      2010-06-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] 嗅覚障害に対するESSの有効性の検討2010

    • Author(s)
      都築建三、竹林宏記、岡秀樹、阪上雅史
    • Organizer
      第111回日本耳鼻咽喉科学会総会・学術講演会
    • Place of Presentation
      仙台市
    • Related Report
      2011 Final Research Report

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Published: 2010-11-30   Modified: 2016-04-21  

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