| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Research Abstract |
Hearing loss against patients of diabetes mellitus bjectives : To evaluate the effects of diabetes on cochlear elements in humans.
Methods : 26 temporal bones(mean age, 37.5 years) with type 1 diabetes and 30 age-matched controls were examined by light microscopy. We compared the findings of cochlear vessels, hair cells, spiral ganglion cells and cochlear lateral walls.
Results : In diabetics, the walls of vessels of the basilar membrane(P<0.001) and vessels of the stria vascularis were(P<0.01) significantly thicker in all turns and loss of outer hair cells(OHCs) was significantly greater in the lower basal turn(P<0.01). Atrophy of the stria vascularis in all turns(P<0.0001) and loss of spiral ligament cells in upper turns(P<0.01) were significantly higher than controls. No significant difference was obtained in the number of spiral ganglion cells between groups.
Conclusion : This study suggests that type 1 diabetes mellitus causes cochlear microangiopathy and degeneration of cochlear lateral walls and OHCs.
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