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Analysis of ZNF143 as a Th2 cytokine regulator in allergic rhinitis

Research Project

Project/Area Number 22791640
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Otorhinolaryngology
Research InstitutionUniversity of Occupational and Environmental Health, Japan

Principal Investigator

WAKASUGI Tetsuro  産業医科大学, 医学部, 助教 (20461569)

Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2012: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Keywords転写因子 / ZNF143 / Th2サイトカイン / アレルギー性鼻炎 / 好酸球
Research Abstract

The expression level of ZNF143 mRNA in human nasal mucosa had significant correlation between IL-5 mRNA, IL-13 mRNA, and the total IgE. This is the result of showing that ZNF143 is participating in the allergic rhinitis through the transcriptional regulation of Th2 cytokines. We consider ZNF143 interacts with GATA-3 and involved in the regulation of the Th2 cytokines.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (38 results)

All 2013 2012 2011 2010

All Journal Article (18 results) (of which Peer Reviewed: 15 results) Presentation (18 results) Book (2 results)

  • [Journal Article] Different expression of erbB1/2 and tight junction proteins in hypertrophic inferior turbinates and nasal polyps2013

    • Author(s)
      Nguyen KH、Wakasugi T、他
    • Journal Title

      Eur Arch Otorhinolaryngol

      Volume: 270巻 Issue: 3 Pages: 945-51

    • DOI

      10.1007/s00405-012-2166-5

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 長期生存した中咽頭腺様嚢胞癌遠隔転移例2013

    • Author(s)
      若杉哲郎
    • Journal Title

      口腔・咽頭科

      Volume: 26 Pages: 97-103

    • NAID

      10031163011

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Case of Primary Hyperparathyroidism with Brown Tumor of the Maxilla2012

    • Author(s)
      若杉哲郎、他
    • Journal Title

      Practica Oto-Rhino-Laryngologica

      Volume: 105 Issue: 10 Pages: 973-980

    • DOI

      10.5631/jibirin.105.973

    • NAID

      10031117863

    • ISSN
      0032-6313, 1884-4545
    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression of epidermal growth factors, erbBs, in the nasal mucosa of patients with chronic hypertrophic rhinitis2012

    • Author(s)
      Nguyen KH、Wakasugi T、他
    • Journal Title

      ORL J Otorhinolaryngol Relat Spec

      Volume: 74巻 Pages: 57-63

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Synergism of Staphyrococcus aureus Colonization and Allergic Reaction in the Nasal Cavity in Mice2012

    • Author(s)
      Hohchi N、Wakasugi T、他
    • Journal Title

      Int Arch Allergy Immunol

      Volume: 159巻 Issue: 1 Pages: 33-40

    • DOI

      10.1159/000335200

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 上顎骨褐色腫を合併した原発性副甲状腺機能亢進症例2012

    • Author(s)
      若杉哲郎
    • Journal Title

      耳鼻咽喉科臨床

      Volume: 105 Pages: 973-980

    • NAID

      10031117863

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of epidermal growth factors, erbBs, in the nasal mucosa of patients with chronic hypertrophic rhinitis.2012

    • Author(s)
      Nguyen KH
    • Journal Title

      ORL J otorhinolaryngol Relat Spec.

      Volume: 74 Issue: 2 Pages: 57-63

    • DOI

      10.1159/000335583

    • Related Report
      2012 Annual Research Report
  • [Journal Article] Molecular Mechanism of Cisplatin Resistance in Head and Neck Cancers2011

    • Author(s)
      若杉哲郎、他
    • Journal Title

      Practica Oto-Rhino-Laryngologica

      Volume: 104 Issue: 3 Pages: 161-170

    • DOI

      10.5631/jibirin.104.161

    • NAID

      10027794055

    • ISSN
      0032-6313, 1884-4545
    • Related Report
      2012 Final Research Report
  • [Journal Article] Prediction model for hearing outcome in patients with idiopathic sudden sensorineural hearing loss2011

    • Author(s)
      Suzuki H、Wakasugi T、他
    • Journal Title

      Eur Arch Otorhinolaryngol

      Volume: 268巻 Issue: 4 Pages: 497-500

    • DOI

      10.1007/s00405-010-1400-2

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 頭頸部癌におけるシスプラチン耐性の分子機序2011

    • Author(s)
      若杉哲郎, 他
    • Journal Title

      耳鼻咽喉科臨床

      Volume: 104 Pages: 161-170

    • NAID

      10027794055

    • Related Report
      2011 Annual Research Report 2010 Annual Research Report
  • [Journal Article] Expression of epidermal growth factors, erbBs, in the nasal mucosa of patients with chronic hypertrophic rhinitis2011

    • Author(s)
      Nguyen KH, Wakasugi T, 他
    • Journal Title

      ORL J Otorhinolaryngol Relat Spec

      Volume: 74 Pages: 57-63

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prediction model for hearing outcome in patients with idiopathic sudden sensorineural hearing loss2011

    • Author(s)
      Suzuki H, Wakasugi T, 他
    • Journal Title

      Eur Arch Otorhinolaryngol

      Volume: 268 Pages: 497-500

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of ZNF143 in tumor growth through transcriptional regulation of DNA replication and cell-cycle-associated genes2010

    • Author(s)
      Izumi H、Wakasugi T、他
    • Journal Title

      Cancer Sience

      Volume: 101巻 Pages: 2538-2545

    • NAID

      10027834347

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clinical significance of ultrasonographic examination including detection of thyroid gland diseases when surveying cervical lymph nodes in subjects with oral squamous cell carcinoma2010

    • Author(s)
      Wakasugi-Sato N, Wakasugi T, Oda M, Yamashita Y, Yoshioka I, Yamamoto N, Habu M, Kodama M, Kokuryo S, Ichimiya H, Miyamoto I, Tanaka T, Kito S, Matsumoto-Takeda S, Ishikawa A, Seta Y, Matsuo K, Takahashi T, Tominaga K, Morimoto Y
    • Journal Title

      Oral Surg Oral Med Oral Pathol Oral Radiol Endod

      Volume: 109 Issue: 6 Pages: 78-85

    • DOI

      10.1016/j.tripleo.2010.01.011

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Role of ZNF143 in tumor growth through transcriptional regulation of DNA replication and cell-cycle-associated genes2010

    • Author(s)
      Izumi H., Wakasugi T., 他
    • Journal Title

      Cancer Science

      Volume: 101 Pages: 2538-2545

    • NAID

      10027834347

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Langerhans cell histiocytosis of the petrous bone with sudden sensorineural hearing loss. Case report.2010

    • Author(s)
      Suzuki H, Wakasugi T, 他
    • Journal Title

      Neurol Med Chir

      Volume: 50 Pages: 693-697

    • NAID

      10026651592

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical significance of ultrasonographic examination including detection of thyroid gland diseases when surveying cervical lymph nodes in subjects with oral squamous cell carcinoma.2010

    • Author(s)
      Wakasugi-Sato N, Wakasugi T, 他
    • Journal Title

      Oral Surg Oral Med Oral Pathol Oral Radiol Endod.

      Volume: 109 Pages: 78-85

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Advanced clinical usefulness of ultrasonography for diseases in oral and maxillofacial regions.2010

    • Author(s)
      Wakasugi-Sato N, Wakasugi T, 他
    • Journal Title

      Int J Dent.

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 頭頸部癌におけるTh細胞サブセット分化に関連する転写因子の発現検討2013

    • Author(s)
      若杉哲郎
    • Organizer
      第31回日本耳鼻咽喉科免疫アレルギー学会
    • Place of Presentation
      倉敷市芸文館(倉敷市)
    • Related Report
      2012 Final Research Report
  • [Presentation] 当科におけるリンパ節生検の検討2013

    • Author(s)
      若杉哲郎
    • Organizer
      第23回頭頸部外科学会
    • Place of Presentation
      城山観光ホテル(鹿児島市)
    • Related Report
      2012 Final Research Report
  • [Presentation] 当科におけるリンパ節生検術の検討2013

    • Author(s)
      若杉哲郎
    • Organizer
      第23回頭頸部外科学会
    • Place of Presentation
      城山観光ホテル(鹿児島市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 頭頸部癌におけるTh細胞サブセット分化に関連する転写因子の発現検討2013

    • Author(s)
      若杉哲郎
    • Organizer
      第31回日本耳鼻咽喉科免疫アレルギー学会
    • Place of Presentation
      倉敷市芸文館(倉敷市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] GATA-3に会合する新規分子ZNF143とTh2サイトカインの発現解析2012

    • Author(s)
      若杉哲郎, 他
    • Organizer
      第30回日本耳鼻咽喉科免疫アレルギー学会
    • Place of Presentation
      琵琶湖ホテル(大津)
    • Year and Date
      2012-02-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] 遠隔転移に対して積極的治療を行い、長期予後が得られている中咽頭腺様嚢胞癌症例2012

    • Author(s)
      若杉哲郎
    • Organizer
      第25回日本口腔・咽頭学会
    • Place of Presentation
      熊本県立劇場(熊本市)
    • Related Report
      2012 Final Research Report
  • [Presentation] 制吐薬3剤併用によるTPF療法の有害事象についての検討2012

    • Author(s)
      若杉哲郎
    • Organizer
      第36回頭頸部癌学会
    • Place of Presentation
      島根県民会館(松江市)
    • Related Report
      2012 Final Research Report
  • [Presentation] GATA-3に会合する新規分子ZNF143とTh2サイトカインの発現解析2012

    • Author(s)
      若杉哲郎
    • Organizer
      第30回日本耳鼻咽喉科免疫アレルギー学会
    • Place of Presentation
      琵琶湖ホテル(大津市)
    • Related Report
      2012 Final Research Report
  • [Presentation] GATA-3に会合する新規分子ZNF143とTh2サイトカインの発現解析2012

    • Author(s)
      若杉哲郎
    • Organizer
      福岡県地方部会第159回耳鼻咽喉科・頭頸部外科学術講演会
    • Place of Presentation
      博多都ホテル(福岡市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 制吐薬3剤併用によるTPF療法の有害事象についての検討2012

    • Author(s)
      若杉哲郎
    • Organizer
      第36回日本頭頸部癌学会
    • Place of Presentation
      島根県民会館(松江)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 遠隔転移に対して積極的治療を行い、長期予後が得られている中咽頭腺様嚢胞癌症例2012

    • Author(s)
      若杉哲郎
    • Organizer
      第25回日本口腔・咽頭科学会
    • Place of Presentation
      熊本県立劇場(熊本市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 頭頸部癌における転写因子ZNF143の機能についての検討2011

    • Author(s)
      若杉哲郎, 他
    • Organizer
      第264回北九州耳鼻咽喉科臨床懇話会
    • Place of Presentation
      リーガロイヤルホテル小倉(北九州)
    • Year and Date
      2011-11-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] シスプラチンによるDNA障害に対する転写因子ZNF143とp73の協調的作用の機能解析2011

    • Author(s)
      若杉哲郎, 他
    • Organizer
      第35回日本頭頸部癌学会
    • Place of Presentation
      ウインク愛知(名古屋)
    • Year and Date
      2011-06-09
    • Related Report
      2011 Annual Research Report
  • [Presentation] 頭頸部癌におけるシスプラチン感受性/耐性因子としての転写因子ZNF143の機能解析2011

    • Author(s)
      若杉哲郎, 他
    • Organizer
      第112回日本耳鼻咽喉科学会総会
    • Place of Presentation
      京都国際会議場(京都)
    • Year and Date
      2011-05-18
    • Related Report
      2011 Annual Research Report
  • [Presentation] シスプラチンによるDNA障害に対する転写因子ZNF143とp73の協調的作用の機能解析2011

    • Author(s)
      若杉哲郎
    • Organizer
      第35回日本頭頸部癌学会
    • Place of Presentation
      ウインク愛知(名古屋市)
    • Related Report
      2012 Final Research Report
  • [Presentation] 頭頸部癌におけるシスプラチン感受性/耐性因子としての転写因子ZNF143の機能解析2011

    • Author(s)
      若杉哲郎
    • Organizer
      第112回日本耳鼻咽喉科学会総会
    • Place of Presentation
      京都国際会議場(京都市)
    • Related Report
      2012 Final Research Report
  • [Presentation] 頭頚部がんにおけるシスプラチンベース化学療法の感受性規定因子としての転写因子ZNF143の機能解析2010

    • Author(s)
      若杉哲郎
    • Organizer
      第34回日本頭頚部癌学会
    • Place of Presentation
      京王プラザホテル(東京都)
    • Year and Date
      2010-06-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] 頭頸部がんにおけるシスプラチンベース化学療法の感受性規定因子としての転写因子ZNF143の機能解析2010

    • Author(s)
      若杉哲郎
    • Organizer
      第34回日本頭頸部癌学会
    • Place of Presentation
      京王プラザホテル(東京都)
    • Related Report
      2012 Final Research Report
  • [Book] 耳鼻咽喉科診療 私のミニマム・エッセンシャル2011

    • Author(s)
      若杉哲郎
    • Publisher
      全日本病院出版会
    • Related Report
      2012 Final Research Report
  • [Book] 耳鼻咽喉科診療私のミニマム・エッセンシャル2011

    • Author(s)
      若杉哲郎, 他
    • Total Pages
      272
    • Publisher
      全日本病院出版会
    • Related Report
      2011 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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